SCIENCE NEWS Insulin Users Have 50% Higher Cancer Risk; Causes Are Unclear, Study Says Diabetics who take insulin have a higher risk of developing cancer, according to Danish researchers who say they can’t explain the link. Patients on insulin were 50 percent more likely to get cancer compared with the general population. [Press release from Bloomberg discussing online presentation abstract for the European Association for the Study of Diabetes]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) DIABETES Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion For the diabetes risk genes TCF7L2 and WFS1, which are associated with impaired incretin signaling, the level of glycemia determines SNP effects on insulin secretion. [Diabetes] Angiotensin-I Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice Findings identify ACE2 as a novel target for the prevention of beta cell dysfunction and apoptosis occurring in type 2 diabetes. [Diabetes] Mcl-1 Downregulation by Pro-Inflammatory Cytokines and Palmitate Is an Early Event Contributing to Beta Cell Apoptosis Data suggest that Mcl-1 downregulation is a crucial event leading to beta cell apoptosis and provide new insights into the mechanisms linking endoplasmic reticulum stress and the mitochondrial intrinsic pathway of apoptosis. [Cell Death Differ] Immobilization of the Soluble Domain of Human Complement Receptor 1 on Agarose-Encapsulated Islets for the Prevention of Complement Activation Researchers aimed to develop a bioartificial pancreas that can realize xeno-islet transplantation. [Biomaterials] Transamination Is Required for Alpha-Ketoisocaproate (KIC) but not Leucine to Stimulate Insulin Secretion KIC and leucine-stimulated insulin secretion occur by enhancing the metabolism of glutamine/glutamate to alpha-ketoglutarate, which in turn is metabolized to produce the intracellular signals such as ATP and NADPH for insulin secretion. [J Biol Chem] The Chaperone Proteins HSP70, HSP40/DnaJ, and GRP78/BiP Suppress Misfolding and Formation of Beta-Sheet-Containing Aggregates by Human Amylin: A Potential Role for Defective Chaperone Biology in Type 2 Diabetes Defective beta cell chaperone biology could contribute to human amylin-misfolding and initiation of apoptosis in type 2 diabetes. [Biochem J] Diabetes and Insulin Duration and Cancer Incidence: A Register Linkage Study in Denmark Researchers found that patients on insulin carry an extra risk of cancer, in the order of magnitude of 50% relative to the general population. [European Association for the Study of Diabetes] PANCREATIC CANCER Pancreatic Adenocarcinoma Upregulated Factor Promotes Metastasis by Regulating TLR/CXCR4 Activation Findings suggest that the new cancer-associated ligand, pancreatic adenocarcinoma upregulated factor (PAUF), may activate Toll-like receptor (TLR)-mediated extracellular signal-regulated kinase signaling to produce the protumorigenic cytokines, but inhibits TLR-mediated nuclear factor-kappaB signaling, thereby facilitating tumor growth and escape from innate immune surveillance. [Oncogene] Aberrant Overexpression of the RGL2 Ral Small GTPase-Specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth Through Ral-Dependent and -Independent Mechanisms Observations support nonredundant roles for RalGEFs in Ras-mediated oncogenesis and a key role for Rgl2 in Ral activation and Ral-independent pancreatic ductal adenocarcinoma growth. [J Biol Chem] Identification and Characterization of a Tumor Infiltrating CD56+/CD16- NK Cell Subset with Specificity for Pancreatic and Prostate Cancer Cell Lines Researchers identified a unique subset of NK cells (CD56brightCD16dim) isolated from a regressing metastatic pancreatic cancer in a patient responding to Ipilimumab. [Cancer Immunol Immunother] CCK-Independent mTORC1 Activation During Dietary Protein-Induced Exocrine Pancreas Growth Prolonged mTORC1 activation is required for dietary protein-induced pancreatic growth in the absence of CCK. [Am J Physiol Gastrointest Liver Physiol]
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INDUSTRY NEWS Roche and Aileron Enter Multi-target Alliance to Develop Stapled Peptide Drugs for Diseases across Multiple Therapeutic Areas Aileron Therapeutics and Roche announced that they have entered into a collaboration to discover, develop and commercialize a new class of drugs called Stapled Peptide Therapeutics. [Aileron Therapeutics Press Release] Sanofi-aventis Announces Non-Binding Offer to Acquire Genzyme Sanofi-aventis announced that it has submitted a non-binding proposal to acquire Genzyme in an all-cash transaction valued at approximately $18.5 billion. [Sanofi-aventis Press Release] Genzyme Confirms Receipt of Unsolicited Proposal Genzyme Corp. confirmed that it has received an unsolicited, non-binding proposal from Sanofi-aventis to acquire all the outstanding shares of Genzyme for $69 per share in cash. The Genzyme board of directors unanimously affirmed its previous rejection of Sanofi’s proposal. [Genzyme Press Release] Biodel to Raise $9.4 Million Through Registered Direct Offering Biodel Inc. announced that it has entered into definitive agreements with two institutional investors to sell 2,398,200 shares of its common stock and warrants to purchase 2,398,200 shares of its common stock. [Biodel Inc. Press Release] Study Links Actos to Heart Risks Actos, the top-selling diabetes drug, causes as many heart problems as Avandia, the pill whose sales tumbled after it was linked to higher heart-disease rates, a study found. [The Boston Globe] MannKind Corporation Providing AFREZZA™ to Juvenile Diabetes Research Foundation for Artificial Pancreas Project MannKind Corporation announced that the company will supply its novel, ultra rapid acting insulin AFREZZA™ (insulin human [rDNA origin]) for use in a study being conducted by the Juvenile Diabetes Research Foundation as part of its Artificial Pancreas Project. [MannKind Corporation Press Release]
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POLICY NEWS The American Diabetes Association Decries New Barrier to Embryonic Stem Cell Research The American Diabetes Association is extremely disappointed by the federal district court decision blocking the federal government from funding research involving embryonic stem cells. [American Diabetes Association, United States] NIH Orders Immediate Shutdown of Intramural Human Embryonic Stem Cell Research Responding to a court order, the National Institutes of Health (NIH) ordered intramural researchers studying human embryonic stem cells to shut down their experiments. [National Institutes of Health, United States] Request for Comments on Synthetic Biology (FR Doc. 2010-21359) [Department of Health and Human Services, United States] Notice of Meeting: Secretary’s Advisory Committee on Genetics, Health, and Society (FR Doc. 2010-21532) [Department of Health and Human Services, United States] National Institute of Diabetes and Digestive and Kidney Diseases Centers for Diabetes Translation Research (P30) (RFA-DK-10-009) [National Institute of Diabetes and Digestive and Kidney Diseases, United States] National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings (FR Doc. 2010-21090) [National Institutes of Health, United States] NIH Director’s Response to Stem Cell Injunction [National Institutes of Health, United States] Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20861) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-21357) [National Institutes of Health, United States] National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-21282) [National Institutes of Health, United States] National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-21280) [National Institutes of Health, United States] Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations [Center for Biologics Evaluation and Research, Untied States] Guidance for Industry: Electronic Submission of Lot Distribution Reports for Biological Products [Center for Biologics Evaluation and Research, Untied States] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice; Public Workshop [FR Doc. 2010-20834] [Food and Drug Administration, United States]
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EVENTS (Listed by Date) The European Molecular Biology Organization (EMBO) Meeting – Advancing the Life Sciences September 4-7, 2010 Barcelona, Spain The Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS) 2010 Scientific Meeting September 9-10, 2010 Oxford, United Kingdom Stem Cells USA & Regenerative Medicine Congress 2010 September 13-15, 2010 Philadelphia, United States Annual Human Proteome Organization (HUPO) World Congress September 19-23, 2010 Sydney, Australia NEW 46th European Association for the Study of Diabetes Annual Meeting September 20-24, 2010 Stockholm, Sweden Institute of Medicine – University of Illinois at Chicago Midwest Conference on Diabetes and Obesity September 21, 2010 Chicago, United States 35th European Society for Medical Oncology (ESMO) Congress October 8-12, 2010 Milan, Italy Fraunhofer Life Science Symposium 2010 October 29-30, 2010 Leipzig, Germany 2010 American Pancreatic Association (APA) Annual Meeting November 3-6, 2010 Chicago, United States Select Biosciences International Forum on Stem Cells November 12-13, 2010 Tianjin, China Australasian Pancreatic Club Annual Meeting November 15-16, 2010 Melbourne, Australia Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction January 12-17, 2011 Dillon, United States 2011 Gastrointestinal Cancers Symposium January 20-22, 2011 San Francisco, United States Epithelial Plasticity and Epithelial to Mesenchymal Transition January 21-26, 2011 Vancouver, Canada Select Biosciences 5th Annual Stem Cells and Regenerative Medicine World Congress January 24-25, 2011 San Diego, United States Phacilitate 7th Annual Cell & Gene Therapy Forum 2011 January 24-26, 2011 Washington, DC, United States Joint Conference of the International Association of Pancreatology and the Indian Pancreas Club February 10-13, 2011 Maradu, India Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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