SCIENCE NEWS Type 1 Diabetes Mortality Rates Dropping Mortality rates for people with type 1 diabetes are decreasing, but overall remain seven times higher than those of the general population — likely as a result of long-term complications. [Press release from the American Diabetes Association discussing online prepublication in Diabetes Care]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) DIABETES Identification of 9-Cis-Retinoic Acid as a Pancreas-Specific Autacoid That Attenuates Glucose-Stimulated Insulin Secretion Data establish 9-cis-retinoic acid as a pancreas-specific autacoid with multiple mechanisms of action and provide unique insight into glucose-stimulated insulin secretion. [Proc Natl Acad Sci U S A] Long-Term In Vitro Human Pancreatic Islet Culture Using Three-Dimensional Microfabricated Scaffolds Researchers investigated the effects of human islet culture within various three-dimensional environments; collagen I gel, collagen I gel supplemented with extracellular matrix (ECM) components fibronectin and collagen IV, and microfabricated scaffold with ECM-supplemented gel. [Biomaterials] All-Cause Mortality Trends in a Large Population-Based Cohort with Long-Standing Childhood-Onset Type 1 Diabetes Although survival has clearly improved, those with diabetes diagnosed most recently (1975-1979) still had a mortality rate 5.6 times higher than that seen in the general population, revealing a continuing need for improvements in treatment and care, particularly for women and African Americans with type 1 diabetes. [Diabetes Care] Insulin Promoter DNA Methylation Correlates Negatively with Insulin Gene Expression and Positively with HbA1c Levels in Human Pancreatic Islets The study demonstrates that DNA methylation of the insulin promoter is increased in patients with type 2 diabetes and correlates negatively with insulin gene expression in human pancreatic islets. [Diabetologia] Dissociation of Lipotoxicity and Glucotoxicity in a Mouse Model of Obesity Associated Diabetes: Role of Forkhead Box O1 (FOXO1) in Glucose-Induced Beta Cell Failure Researchers used a sequential dietary regimen to dissociate the effects of obesity and hyperglycemia on beta cell function and integrity, and to study glucose-induced alterations of key transcription factors over 16 days. [Diabetologia] Co-Immobilization of Urokinase and Thrombomodulin on Islet Surfaces by Poly(Ethylene Glycol)-Conjugated Phospholipid Researchers propose a versatile method for modifying the surface of islets with the fibrinolytic enzyme urokinase and the soluble domain of the anticoagulant enzyme thrombomodulin. [J Control Release] PANCREATIC CANCER Continuous Cell Supply from a Sox9-Expressing Progenitor Zone in Adult Liver, Exocrine Pancreas and Intestine Researchers show that Sox9 is expressed throughout the biliary and pancreatic ductal epithelia, which are connected to the intestinal stem cell zone. [Nat Genet] Adaptive Unfolded Protein Response Attenuates Alcohol-Induced Pancreatic Damage Researchers investigated the role of X box-binding protein 1, an unfolded protein response regulator, in prevention of alcohol-induced endoplasmic reticulum stress in the exocrine pancreas. [Gastroenterology] miR-301a as an NF-KappaB Activator in Pancreatic Cancer Cells Researchers investigated whether microRNAs (miRNAs) contribute to NF-kappaB activation in pancreatic cancer. They demonstrated that miR-301a down-regulates NF-kappaB-repressing factor and elevates NF-kappaB activation. [EMBO J] Epithelial Dynamics of Pancreatic Branching Morphogenesis Results illustrate distinct, step-wise cellular mechanisms by which pancreatic epithelium shapes itself to create a functional branching organ. [Development] Plectin-1 as a Novel Biomarker for Pancreatic Cancer Plectin-1 is the first biomarker to identify primary and metastatic pancreatic cancer by imaging and may also detect preinvasive PanIN III lesions. [Clin Cancer Res] Ligand Stimulation of ErbB4 and a Constitutively-Active ErbB4 Mutant Result in Different Biological Responses in Human Pancreatic Tumor Cell Lines Researchers demonstrate that human pancreatic tumor cell lines exhibit minimal ErbB4 expression; in contrast, these cell lines exhibit varied and in some cases abundant expression and basal tyrosine phosphorylation of EGFR, ErbB2, and ErbB3. [Exp Cell Res]
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EVENTS (Listed by Date) Pharmacology in Stem Cells Research and Regenerative Medicine December 17, 2010 London, United Kingdom The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine December 17-19, 2010 Guangzhou, China Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction January 12-17, 2011 Dillon, United States Keystone Symposia: Obesity January 12-17, 2011 Keystone, United States 2011 Gastrointestinal Cancers Symposium January 20-22, 2011 San Francisco, United States Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition January 21-26, 2011 Vancouver, Canada 5th Annual Stem Cells and Regenerative Medicine World Congress January 24-25, 2011 San Diego, United States Phacilitate 7th Annual Cell & Gene Therapy Forum 2011 January 24-26, 2011 Washington, D.C., United States Early Development for Innovative Diabetes & Metabolic Syndrome Therapeutics Conference January 26-27, 2011 Amsterdam, The Netherlands Joint Conference of the International Association of Pancreatology and the Indian Pancreas Club February 10-13, 2011 Maradu, India 2nd Annual International Diabetes Summit February 22-24, 2011 Dubai, United Arab Emirates NEW World Cell Culture Congress 2011 February 28-March 2, 2011 Munich, Germany NEW PITTCON 2011 March 13-18, 2011 Atlanta, United States United Kingdom National Stem Cell Network 2011 Annual Scientific Conference March 30-April 1, 2011 York, United Kingdom American Association for Cancer Research (AACR) 102nd Annual Meeting 2011 April 2-6, 2011 Orlando, United States NEW World Stem Cells & Regenerative Medicine Congress 2011 May 9-11, 2011 London, United Kingdom 13th Annual C21 BioVentures May 24-26, 2011 Napa, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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