Pancreatic Cell News 10.07 February 26, 2019 | |
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TOP STORYCellular Sickness Linked to Type 1 Diabetes Onset A University of California San Francisco study of human and mouse pancreatic tissue suggests a new origin story for type 1 diabetes. The findings flip current assumptions about the causes of the disease on their head and demonstrate a promising new preventative strategy that dramatically reduced disease risk in laboratory animals. [Press release from University of California San Francisco discussing online prepublication in Cell Metabolism] Press Release | Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISGLP-1 Signaling Suppresses Menin’s Transcriptional Block by Phosphorylation in β Cells Researchers showed that glucagon-like peptide 1 (GLP-1) signaling-activated protein kinase A directly phosphorylated menin at the serine 487 residue, relieving menin-mediated suppression of insulin expression and cell proliferation. [J Cell Biol] Abstract Using Stat5b gene silencing and overexpression models in the MIN6 mouse pancreatic β-cell line, the authors assayed nitric oxide and its end products, superoxide levels, H2O2 levels, and expression of genes related to redox pathway by immunocytochemistry, biochemical assays, quantitative real time PCR and western blotting. [Cell Physiol Biochem] Full Article Expression of a presenlin-1 mutant that mimicked GSK3β-mediated phosphorylation established a β-cell-like endoplasmic reticulum (ER) Ca2+ leak in HeLa and EA.hy926 cells. The ER Ca2+ loss in β-cells was compensated at steady state by Ca2+ entry that was linked to the activity of TRPC3. [Cell Physiol Biochem] Full Article Investigators predicted activity changes in a number of kinases including NUAK1, not or only poorly studied in the context of the pancreatic beta-cell. Furthermore, they pharmacologically tested whether signaling pathways predicted by kinase-substrate enrichment analysis affected glucose-dependent acceleration of mitochondrial respiration. [Cell Commun Signal] Full Article PANCREATIC CANCERIrreversible Electroporation Reverses Resistance to Immune Checkpoint Blockade in Pancreatic Cancer The combination of irreversible electroporation and anti-programmed cell death protein 1 immune checkpoint blockade promoted selective tumor infiltration by CD8+ T cells and significantly prolonged survival in a murine orthotopic pancreatic ductal adenocarcinoma model with a long-term memory immune response. [Nat Commun] Full Article MST1 Suppresses Pancreatic Cancer Progression via ROS Induced Pyroptosis Scientists showed that mammalian STE20-like kinase 1 (MST1) had decreased expression in pancreatic ductal adenocarcinoma (PDAC), and restored expression of MST1 promoted PDAC cell death and suppressed the proliferation, migration, invasion and cell spheroid formation of PDAC via caspase-1 induced pyroptosis. [Mol Cancer Res] Abstract Blockade of Integrin α3 Attenuates Human Pancreatic Cancer via Inhibition of EGFR Signaling Ablation of integrin α3 expression resulted in a significant decrease of epidermal growth factor receptor (EGFR) expression compared with transfection of control-siRNA through an increased number of leucine-rich repeats and immunoglobulin-like domain protein 1 expression. [Sci Rep] Full Article Insm1-deficient human cell lines expressed stem cell markers, were more invasive in vitro, and metastasized at higher rates in vivo when compared to isogenic Insm1-expressing cell lines. [Oncogenesis] Full Article CD110 Promotes Pancreatic Cancer Progression and Its Expression Is Correlated with Poor Prognosis Treatment with thrombopoietin promoted pancreatic cancer cell extravasation. In the presence of thrombopoietin, CD110 increased cell viability through the activation of the ERK-MYC signaling pathway. [J Cancer Res Clin Oncol] Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSDiabetes and Cancer: Debating the Link through Ca2+/cAMP Signaling The author debates the possible involvement of Ca2+/cAMP signaling in the clinical link between diabetes and a higher risk for the development of several types of cancer, including the plausible involvement in both anti-cancer and anti-diabetic effects of calcium channel blockers. [Cancer Lett] Abstract Beta Cells in Type 1 Diabetes: Mass and Function; Sleeping or Dead? Investigators review recent contributions to the debate around beta cell abnormalities contributing to the pathogenesis of type 1 diabetes. They also discuss evidence for restoration of beta cell function, as opposed to mass, in recent-onset type 1 diabetes, but highlight the absence of data supporting functional recovery in the setting of long-duration diabetes. [Diabetologia] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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SCIENCE NEWSMannKind Presents New Scientific Data MannKind Corporation announced additional positive Afrezza clinical data was presented in an oral presentation and a poster. [Press release from MannKind Corporation discussing research presented at 12th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD 2019), Berlin] Press Release | |
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INDUSTRY NEWSAstraZeneca and MSD Inc. announced positive results from the Phase III POLO trial. Results from the trial showed a statistically-significant and clinically-meaningful improvement in progression-free survival with Lynparza vs. placebo. [AstraZeneca] Press Release The Phase III THEMIS trial met its primary endpoint and demonstrated that Brilinta, taken in conjunction with aspirin, showed a statistically-significant reduction in a composite of major adverse cardiovascular events compared to aspirin alone. [AstraZeneca] Press Release | |
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POLICY NEWSMoldovan Mathematician among Academics Running in General Election Several researchers, including one mathematician, are running for seats in Moldova’s parliament this month. They hope to depoliticize science, improve education and address high levels of brain drain in the small country of 3.5 million people. [Nature News] Editorial Open-Access Pioneer Randy Schekman on Plan S and Disrupting Scientific Publishing Nobel laureate Randy Schekman shook up the publishing industry when he launched the open-access journal eLife in 2012. Armed with millions in funding from three of the world’s largest private biomedical charities – the Wellcome Trust, the Max Planck Society and the Howard Hughes Medical Institute – Schekman designed the journal to compete with publishing powerhouses such as Nature, Science and Cell. [Nature News] Editorial
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EVENTSNEW Keystone Symposia: Diabetes – Glucose Control and Beyond Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Pancreatic Development & Islet Biology (Vanderbilt University) Postdoctoral Position – Pancreatic Tissue Engineering (King’s College London) Postdoctoral Research Assistant – Stem Cell and Cancer Research (University of Oxford) Professor – Diabetes (University of California, San Diego) PhD Position – Pancreatic Cancer (Universitätsklinikum Münster) Postdoctoral Fellow – Pancreatic Beta-Cells (City of Hope) Clinical Professor – Diabetes (University of Southern Denmark) Postdoctoral Fellowship – Pancreatic Cancer (Dartmouth College) Postdoctoral Fellowships – Cancer (Albert Einstein College of Medicine of Yeshiva University) Faculty Positions – Diabetes and Metabolism (Texas Tech University) Postdoctoral Fellow – Neuroscience and Diabetes (The Child Health Institute of New Jersey) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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