Pancreatic Cell News Volume 10.12 | Apr 2 2019

TOP STORY

Syndecan 1 Is a Critical Mediator of Macropinocytosis in Pancreatic Cancer

The authors developed an unbiased, functional target-discovery platform to query oncogenic KRAS (KRAS*)-dependent changes of the pancreatic ductal adenocarcinoma surfaceome, which revealed syndecan 1 as a protein that is upregulated at the cell surface by KRAS*. [Nature] Abstract | Press Release

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

YAP Inhibition Enhances the Differentiation of Functional Stem Cell-Derived Insulin-Producing β Cells

Scientists report that the Hippo pathway controls the proliferation and specification of pancreatic progenitors into the endocrine lineage. [Nat Commun] Full Article

Impaired TFEB-Mediated Lysosomal Biogenesis Promotes the Development of Pancreatitis in Mice and Is Associated with Human Pancreatitis

Genetic deletion of transcription factor EB (tfeb) specifically in mouse pancreatic acinar cells increased pancreatic edema, necrotic cell death, infiltration of inflammatory cells and fibrosis in pancreas after cerulein treatment. [Autophagy] Abstract

A Novel Optical Tracer for VMAT2 Applied to Live Cell Measurements of Vesicle Maturation in Cultured Human β-Cells

The authors report on the synthesis and biological characterization of a fluorescent ligand for vesicular monoamine transporter type 2 (VMAT2) suitable for live cell imaging. Staining for VMAT2 and dopamine in live β-cell cultures showed colocalization in specific vesicles and revealed a heterogeneous population with respect to cell size, shape, vesicle number, size, and contents. [Sci Rep] Full Article

Distribution of Pancreatic Islet Endocrine Cells and Antioxidant Enzymes in Streptozotocin-Injected Rats during Postnatal Critical Development Window

Investigators performed a temporal analysis of the distribution pattern of islet endocrine cells and pancreatic antioxidant enzymes in rats with and without diabetes during the post-natal critical development window. [Life Sci] Abstract

Glucagon Receptor Antagonism Increases Mouse Pancreatic δ-Cell Mass through Cell Proliferation and Duct-Derived Neogenesis

Scientists found that REMD 2.59, a human monoclonal antibody and competitive antagonist of the glucagon receptor, massively boosted δ-cell number and increased plasma somatostatin level in both normoglycemic and type 1 diabetic mice. [Biochem Biophys Res Commun] Abstract

PANCREATIC CANCER

Impact of the Secretome of Activated Pancreatic Stellate Cells on Growth and Differentiation of Pancreatic Tumor Cells

Investigating how pancreatic stellate cells (PSCs) contribute to tumor development and for to identify proteins that the cells secrete during cancer progression, the authors studied by means of complex antibody microarrays the secretome of activated PSCs. [Sci Rep] Full Article

Homeodomain‐Interacting Protein Kinase 2 Suppresses Proliferation and Aerobic Glycolysis via ERK/cMyc Axis in Pancreatic Cancer

Overexpression of homeodomain‐interacting protein kinase (HIPK)2 in pancreatic cancer cells decreased cell proliferation and attenuated aerobic glycolysis, which sustained proliferation of cancer cells. HIPK2 decreased cMyc protein levels and expression of cMyc‐targeted glycolytic genes. [Cell Prolif] Full Article

TM4SF18 Is Aberrantly Expressed in Pancreatic Cancer and Regulates Cell Growth

Researchers investigated the expression and localization of the TM4SF18 protein in normal human pancreas and in pancreatic ductal adenocarcinoma (PDAC) tissue. Utilizing immunohistochemistry and western blot analysis, they demonstrated that TM4SF18 was highly expressed in the PDAC tumor epithelium. [PLoS One] Full Article

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TAMing Pancreatic Cancer: Combat with a Double Edged Sword

Accumulating evidence exposes the crucial role played by tumor-associated macrophages in pancreatic cancer and this review briefly presents the origin from their parent lineage and the importance in maintaining tumor hallmarks. [Mol Cancer] Full Article

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

Janssen Submits Supplemental New Drug Application to U.S. FDA for INVOKANA^® (Canagliflozin) for the Treatment of Chronic Kidney Disease in Patients with Type 2 Diabetes

The Janssen Pharmaceutical Companies of Johnson & Johnson announced the submission of a supplemental New Drug Application to the FDA seeking a new indication for INVOKANA^® to reduce the risk of end-stage kidney disease (ESKD), the doubling of serum creatinine, which is a key predictor of ESKD, and renal or cardiovascular death in adults with type 2 diabetes and chronic kidney disease. [Janssen Global Services, LLC] Press Release

The Pancreatic Cancer Collective Funds Two New Research Teams Using Artificial Intelligence to Identify High-Risk Pancreatic Cancer Populations

The Pancreatic Cancer Collective and Stand Up To Cancer announced two, million-dollar grants for computational approaches to identifying high-risk pancreatic cancer populations. [The Pancreatic Cancer Collective] Press Release

What Thailand’s Long-Awaited Election Could Mean for Science

Thailand is bracing for the results of its first election since a military junta took charge in a 2014 coup. Scientists, like many other people in Thailand, want a more democratic country. But whether a pro-democracy party or a military-backed one ends up in charge, science is likely to prosper as a result of ongoing reforms put in place by the junta that are likely to continue under either government. [Nature News] Editorial

National Academy of Sciences Will Vote on Ejecting Sexual Harassers

The U.S. National Academy of Sciences in Washington, D.C., will ask its members to change the organization’s bylaws to allow proven sexual harassers and those guilty of other misconduct to be ejected from their ranks. That’s a first for the prestigious organization that advises the U.S. government on scientific issues: Its members, who are voted in by other members, have always been elected for life. [ScienceInsider] Editorial

NEW Society for Immunotherapy of Cancer (SITC) 2019
November 6-10, 2019
National Harbor, Maryland, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Beta-Cell Regeneration in Zebrafish (Karolinska Institutet)

NEW Postdoctoral Research Fellow – Type 2 Diabetes and Obesity (Harvard Medical School/Boston Children’s Hospital)

PhD Position – Pancreatic Cancer (Philipps-Universität Marburg)

Postdoctoral Fellowship – Regenerative Medicine and Metabolic Biology (Indiana Biosciences Research Institute)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

Postdoctoral Fellowship – Pancreatic Islet Cells (Karolinska Institutet)

Postdoctoral Position – Diabetes (University of Minnesota)

Postdoctoral Fellow – Pancreatic Development & Islet Biology (Vanderbilt University)

Professor – Diabetes (University of California, San Diego)

Postdoctoral Fellow – Neuroscience and Diabetes (The Child Health Institute of New Jersey)

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