Pancreatic Cell News 10.20 May 28, 2019 | |
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TOP STORYβ Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes Scientists demonstrated that deletion of the transcription factor hypoxia-inducible factor-1α from β cells increased the susceptibility of non-obese diabetic mice to environmentally triggered type 1 diabetes from coxsackieviruses and the β cell toxin streptozotocin. [Cell Rep] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISSTAT3 Dictates β-Cell Apoptosis by Modulating PTEN in Streptozocin-Induced Hyperglycemia Researchers observed that activation of STAT3 was intensely and specifically inhibited in β-cells under hyperglycemic conditions. By knocking out STAT3 specifically in mouse β-cells, they found that the loss of STAT3 sensitized mice to three low doses of STZ stimulation resulting in hyperglycemia. [Cell Death Differ] Abstract The authors studied the impact of type 2 diabetes (T2D) on open chromatin in human pancreatic islets. They used assay for transposase-accessible chromatin using sequencing (ATAC-seq) to profile open chromatin in islets from T2D and non-diabetic donors. [Sci Rep] Full Article Rat pancreatic acinar cell line AR42J was treated with caerulein to construct an acute pancreatitis cell model. Quantitative real-time polymerase chain reaction was performed to measure the expression of miR-27a-5p. [J Cell Biochem] Abstract E4orf1 Protein Reduces the Need for Endogenous Insulin Scientists tested if the E4orf1-mediated lowering of insulin response was due to increased tissue sensitivity to insulin, reduced ability to produce or release insulin, or a reduced need for insulin release. [Nutr Diabetes] Full Article PANCREATIC CANCERIn pancreatic tissues, p-extracellular signal-regulated kinase (ERK) 1/2 was strongly expressed in cancer-associated pancreatic cancer cells (PSCs) compared with cancer cells and normal PSCs. PSCs were also significantly more sensitive to ERK1/2 inhibitor treatment. [J Exp Clin Cancer Res] Full Article Whereas the expression of most S100 proteins was characteristic for epithelial pancreatic ductal adenocarcinoma cell lines, S100A4 and S100A6 were strongly expressed in mesenchymal cells and upregulated by ZEB1. [Br J Cancer] Full Article Cryptotanshinone (KIS37) inhibited anchorage-independent growth in three-dimensional spheroid and soft agar colony formation assays of KRAS-activated human pancreatic and colorectal cancer cell lines. KIS37 also suppressed KRAS protein expression in such cell lines. [Mol Carcinog] Abstract Investigators compared the protein expression profiling of pancreatic ductal adenocarcinoma cells and its distinct surviving cells following primary treatment with gemcitabine and 5-fluorouracil by two-dimensional electrophoresis combined with liquid chromatography-mass spectrometry or mass spectrometry. [Invest New Drugs] Abstract Researchers report that teriflunomide not only showed in vitro anti-proliferative activity in pancreatic cancer (PC) cells as a single agent but also synergized with the chemotherapeutic gemcitabine in growth inhibition of PC cells. [Mol Ther Oncolytics] Abstract | Full Article Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSNew Insights into Acute Pancreatitis The authors provide a summary of recent advances in acute pancreatitis with a special emphasis on pathophysiological mechanisms and clinical management of the disorder. [Nat Rev Gastroenterol Hepatol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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SCIENCE NEWSCorcept Therapeutics Incorporated will present data from the Phase I/II study of its proprietary, selective cortisol modulator, relacorilant, in combination with nab-paclitaxel in patients with solid tumors. [Press release from Corcept Therapeutics Incorporated discussing research to be presented at the 2019 Annual Meeting of the American Society of Clinical Oncology (ASCO), Chicago] Press Release | |
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INDUSTRY NEWSStem Cell Agency Board Approves New Clinical Trial for Type 1 Diabetes The governing Board of the California Institute for Regenerative Medicine awarded $11.08 million to Dr. Peter Stock at the University of California San Francisco to conduct a clinical trial for treatment of Type 1 Diabetes. [California Institute for Regenerative Medicine] Press Release The Janssen Pharmaceutical Companies announced that the FDA has granted Priority Review for the supplemental New Drug Application (sNDA) for INVOKANA® to reduce the risk of end-stage kidney disease, the doubling of serum creatinine, and renal or cardiovascular death in adults with type 2 diabetes and chronic kidney disease. [Janssen Pharmaceutical Companies] Press Release | |
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POLICY NEWSTaiwan Considers Double-Blind Peer Review for Grants Taiwan’s science ministry is thinking of introducing double-blind peer review to assess research-grant proposals, a trend being adopted by some journals to eliminate bias. [Nature News] Editorial Brazilian Scientists Strive to Turn Politicians into Allies Brazil’s scientists are fighting back against President Jair Bolsonaro’s plans to slash funding for research and education programs. Researchers have joined with members of Brazil’s legislature, the National Congress, to highlight the strategic role that science, technology, and education play in the country’s economic and social development. [Nature News] Editorial
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EVENTSNEW 7th Helmholtz Diabetes Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Scientist – Genetic and Genomic Epidemiology (International Agency for Research on Cancer) NEW Postdoctoral Fellow – Preclinical Cancer Research (Karolinska Institutet) Postdoctoral Position – Lung and Pancreatic Cancers (University of California, San Francisco) Professor – Diabetes Research (University of Tennessee Health Science Center) Postdoctoral Researcher – Islet Biology (University of Wisconsin-Madison) Postdoctoral Fellowship – Pancreatic Cancer (Oregon Health and Science University) Postdoctoral Fellowship – Regenerative Medicine (Cornell University) Postdoctoral Research Position – Molecular Biology and Cancer Research (Augusta University) Postdoctoral Research Affiliate – Pancreatic Cancer Research (Roswell Park) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Postdoctoral Fellow – Neuroscience and Diabetes (The Child Health Institute of New Jersey) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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