Pancreatic Cell News 10.22 June 11, 2019 | |
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TOP STORYCells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates Researchers report that Akita mutant proinsulin formed detergent-insoluble aggregates that entrapped wild-type proinsulin in the endoplasmic reticulum, thereby blocking insulin production. [Mol Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISDiabetes Causes Marked Inhibition of Mitochondrial Metabolism in Pancreatic β-Cells INS-1 β-cells cultured chronically at high glucose showed changes in protein expression and reduced glucose-stimulated oxygen consumption; targeted metabolomics revealed impaired metabolism. [Nat Commun] Full Article Researchers report that acute glucose stimulation stimulated endoplasmic reticulum (ER)-mitochondria interactions and calcium (Ca2+) exchange in INS-1E cells, whereas disruption of mitochondria-associated membranes altered glucose-stimulated insulin secretion. [Diabetes] Abstract A persistent coxsackieviruses-B infection was established in 1.1B4 pancreatic beta cells. The proportion of cells containing viral protein VP1 was low, although a large proportion of cells harbored viral RNA, whilst cell viability was preserved. [Cell Mol Life Sci] Abstract A beta cell injury model was established with palmitic acid to simulate the lipotoxicity found in type 2 diabetes mellitus. Sonodynamic therapy, a novel physicochemical treatment, was applied to treat injured beta cells. [Cell Death Dis] Full Article Anti-human (h) CLDN18.2 ADC, CD3-bispecific and diabody, targeting a protein sequence conserved in rat, mouse and monkey, exhibited in vitro cytotoxicity in BxPC3/hCLDN18.2 and KATO-III/hCLDN18.2 respectively and inhibited tumor growth of pancreatic and gastric patient-derived xenograft tumors. [Sci Rep] Full Article PANCREATIC CANCEROxoglutarate dehydrogenase like (OGDHL) was downregulated in human pancreatic cancer and predicted poor prognosis. OGDHL overexpression inhibited migration and invasion of pancreatic cancer cells and suppressed pancreatic cancer tumor growth. [Clin Cancer Res] Abstract | Full Article TMEM16A Controls EGF-Induced Calcium Signaling Implicated in Pancreatic Cancer Prognosis In vitro, TMEM16A was required for EGF-induced store-operated calcium entry essential for pancreatic cancer cell migration. TMEM16A also had a profound impact on phosphoproteome remodeling upon EGF stimulation. [Proc Natl Acad Sci USA] Abstract The authors explored the potential of targeting cystine/glutamate exchanger (SLC7A11/xCT), which contributed to the maintenance of intracellular glutathione. Genomic disruption of xCT via CRISPR-Cas9 was achieved in two pancreatic ductal adenocarcinoma (PDAC) cell lines and xCT-KO clones were cultivated in the presence of N-acetylcysteine. [Cancer Res] Abstract | Full Article In contrast to previous reports and consistent with a concept of retained tumor suppressive transforming growth factor β (TGFβ) activity, even in established pancreatic ductal adenocarcinoma (PDAC), TGFβ treatment reduced PDAC cell proliferation and promoted apoptosis even in the presence of oncogenic nuclear factor of activated T cells (NFATc1). [Cell Death Dis] Full Article Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSTools for Bioimaging Pancreatic β Cells in Diabetes The authors explore the need to bioimage human β cells noninvasively in various types of diabetes, and they discuss current and emerging tools for bioimaging β cells. [Trends Mol Med] Abstract Platelets as Potent Signaling Entities in Type 2 Diabetes Mellitus Investigators highlight how circulating inflammatory molecules, acting as platelet receptor ligands, interact with platelets, causing platelets to be potent drivers of systemic inflammation. [Trends Endocrinol Metab] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSProtokinetix Achieves Primary Objective Safety at Midpoint of Clinical Trial ProtoKinetix, Incorporated announced reaching the midpoint of a Phase I first-in-human clinical trial of AAGPâ„¢ PKX-001 treated islet cells used in conjunction with the Edmonton Protocol for the treatment of Type-1 diabetes. [ProtoKinetix, Inc.] Press Release Adocia announced the initiation of a Phase Ib study of ADO09, a ready-to-use, fixed ratio co-formulation of pramlintide, the only FDA-approved analog of amylin, and A21G human insulin analog, a rapid-acting insulin that is known to be the main circulating metabolite of insulin glargine. [Adocia] Press Release Beta Bionics, Inc. and Zealand Pharma A/S announced that a home-use study of dasiglucagon in the iLetâ„¢ Bionic Pancreas System has been successfully completed. [Beta Bionics, Inc. (GlobeNewswire, Inc.)] Press Release Cotinga Pharmaceuticals Inc. announced that it has initiated the third cohort of its ongoing Phase Ib/IIa clinical trial of COTI-2 plus cisplatin in solid tumors. [Cotinga Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSSudanese Academics Defiant as Revolution Turns Bloody Sudan’s universities are shut, flights have been suspended and the Internet remains almost entirely blocked after a brutal crackdown in which paramilitaries are thought to have killed some 100 pro-democracy protestors. But none of this has dented the resolve of the protestors, whose ranks include several prominent academics and whose demands include freeing universities from government influence. [Nature News] Editorial Wellcome Sanger Institute to Close Animal Facility The Wellcome Sanger Institute announced that it would be closing its animal facility, which provides mice, zebrafish, rats, and frogs to geneticists at the institute and internationally, reports Nature. The institute states that the closure is related to the growing use of cell lines and organoids, instead of animals. [The Scientist] Editorial
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EVENTSNEW European Congress on Clinical and Translational Medicine (EUSTM) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Student – Diabetes (University of Edinburgh) Scientist – Genetic and Genomic Epidemiology (International Agency for Research on Cancer) Postdoctoral Fellow – Preclinical Cancer Research (Karolinska Institutet) Postdoctoral Position – Lung and Pancreatic Cancers (University of California, San Francisco) Professor – Diabetes Research (University of Tennessee Health Science Center) Postdoctoral Fellowship – Pancreatic Cancer (Oregon Health and Science University) Postdoctoral Fellowship – Regenerative Medicine (Cornell University) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Postdoctoral Fellow – Neuroscience and Diabetes (The Child Health Institute of New Jersey) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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