Pancreatic Cell News 10.25 July 2, 2019 | |
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TOP STORYEnhancer Signatures Stratify and Predict Outcomes of Non-Functional Pancreatic Neuroendocrine Tumors Using enhancer maps to infer gene regulatory programs, researchers found that non-functional pancreatic neuroendocrine tumors fell into two major subtypes, with epigenomes and transcriptomes that partially resembled islet α- and β-cells. [Nat Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISScientists created promoter capture Hi-C maps in human pancreatic islets. This linked diabetes-associated enhancers to their target genes, often located hundreds of kilobases away. [Nat Genet] Abstract The authors developed an optimized dipheylthiocarbazone or dithizone with improved physical and chemical properties to characterize human islets and insulin-producing cells differentiated from embryonic stem cells. [Sci Rep] Full Article Researchers characterized the pancreatic alpha-cell mass and its regulatory processes in the transgenic RIP-B7.1 mice model of experimental autoimmune diabetes. Diabetic mice presented insulitis, hyperglycaemia, hypoinsulinemia and hyperglucagonemia along with lower pancreatic insulin content. [Sci Rep] Full Article Investigators demonstrated that vitamin D levels were significantly lower in 40 gestational diabetes mellitus patients. The silencing of the vitamin D receptor decreased cell survival and increased both FoxO1 mRNA and protein expression. [Biomed Pharmacother] Full Article Tauroursodeoxycholic acid, an inhibitor of endoplasmic reticulum stress, significantly attenuated N-methyl-d-aspartate (NMDA)-induced β-cell dysfunction, including the loss of glucose-stimulated insulin secretion and reduction of pancreas duodenum homeobox factor-1 mRNA expression, a transcription factor regulating insulin synthesis. [Life Sci] Full Article PANCREATIC CANCEREGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis Scientists provided evidence that a subset of pancreatic ductal adenocarcinoma tumors were wired to integrate contextual metabolic inputs to regulate macropinocytosis, dialing up or down this uptake pathway depending on nutrient availability. [Dev Cell] Full Article | Press Release | Graphical Abstract The authors discovered that neratinib interacted with the chemically distinct irreversible ERBB1/2/4 inhibitor afatinib to reduce expression of ERBB1, ERBB2, K-RAS and N-RAS; this was associated with greater-than-additive cell killing of pancreatic tumor cells. [Oncogene] Abstract Genetic suppression of glutamine transaminase K (GTK), a key enzyme of the glutaminase II pathway, led to complete inhibition of pancreatic tumorigenesis in vivo, unveiling GTK as a new metabolic target for cancer therapy. [Proteomics] Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSThe authors evaluate the association between miRNAs and response to chemotherapy in pancreatic cancer patients. [Cancers] Full Article Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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SCIENCE NEWSCRISPR Therapeutics Announces Oral Presentation CRISPR Therapeutics announced that it will present an oral presentation: “CRISPR-editing of hESCs allows for production of immune evasive cells capable of differentiation to pancreatic progenitors for future type 1 diabetes therapy”. [Press release from CRISPR Therapeutics discussing research to be presented at the 55th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona] Press Release | |
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INDUSTRY NEWSActoBio Therapeutics™ has announced that it will progress to the next stage of the Phase Ib/IIa clinical trial for investigational drug AG019 for the treatment of early-onset type 1 diabetes. [ActoBio Therapeutics™] Press Release Cotinga Pharmaceuticals Inc. announced that the company has commenced dosing patients in the third cohort of its ongoing Phase Ib/IIa clinical trial of COTI-2 plus cisplatin in solid tumors. [Cotinga Pharmaceuticals Inc. (GlobeNewswire, Inc.)] Press Release Seven Scientists Receive PanCAN Research Grants The Pancreatic Cancer Action Network (PanCAN) has announced the recipients of its 2019 research grants. Seven grants, totaling to more than $3 million, were awarded this year, bringing PanCAN’s total projected research investment to approximately $104 million, including its grants program and clinical and scientific initiatives. [Pancreatic Cancer Action Network] Press Release | |
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POLICY NEWSGermany’s Prestigious Max Planck Society Conducts Huge Bullying Survey Most of the scientists who work for one of the world’s richest and most prestigious basic research organizations, the Max Planck Society (MPS) in Germany, have pride and trust in their institutes — but cases of sexual discrimination and bullying occur regularly, and nearly half of foreign scientists working for the MPS don’t feel they fit in. [Nature News] Editorial Taiwan to Crack Down on Unauthorized Research Collaborations with Mainland China According to Taiwan’s Central News Agency, the island’s government is investigating seven researchers for allegedly joining a prestigious programme sponsored by the mainland China government to lure academics to the mainland without the necessary permissions. [Nature News] Editorial
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EVENTSNEW 55th Annual Meeting of the European Association for the Study of Diabetes (EASD) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Scientist – Endocrine Pancreas Development (Helmholtz Zentrum München) NEW Postdoctoral Position – Immunology (Roswell Park Cancer Institute) Postdoctoral Researcher – Pancreas Cancer Research (Fred Hutchinson Cancer Research Center) Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California) Postdoctoral Fellow – Cancer Drug Response Research (University of Texas at Austin) Postdoctoral Position – Lung and Pancreatic Cancers (University of California, San Francisco) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Postdoctoral Fellow – Neuroscience and Diabetes (The Child Health Institute of New Jersey) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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