Pancreatic Cell News 10.36 September 17, 2019 | |
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TOP STORYScientists report stroma-rich heterotypic pancreatic ductal adenocarcinoma in vitro and in vivo models incorporating patient-derived pancreatic cancer-associated fibroblasts that recapitulated the desmoplasia observed in the clinic. [Nano Lett] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISThe authors showed that Cre recombinase-mediated conditional deletion of Atp6ap2 in mouse β cells caused a dramatic accumulation of large, multigranular vacuoles in the cytoplasm, with reduction of insulin content and compromised glucose homeostasis. [Proc Natl Acad Sci USA] Abstract Genetic ablation of C2cd4a in β cells of mice phenocopied the metabolic abnormalities of human carriers of C2CD4A-linked polymorphisms, resulting in impaired insulin secretion during glucose tolerance tests as well as hyperglycemic clamps. [Proc Natl Acad Sci USA] Abstract Cdk8 ablation in β cells aggravated apoptosis and induced de novo expression of neuropeptides upon oxidative stress. Pancreatic islets exposed to stress displayed augmented apoptosis in the presence of these same neuropeptides. [Cell Rep] Full Article | Graphical Abstract Inactivation of NEUROD1 in human embryonic stem cells severely impaired their differentiation from pancreatic progenitors into insulin expressing cells; however survival or proliferation was not affected at the time points analyzed. [Diabetes] Abstract β-cells were engineered with stable photoactivatable adenylyl cyclase expression that led to over 2-fold greater glucose-stimulated insulin secretion upon exposure to blue light while there were no changes in the absence of glucose. Transplantation of these cells into streptozotocin-treated mice resulted in improved glucose tolerance, lower hyperglycemia, and higher plasma insulin when subjected to illumination. [ACS Synth Biol] Abstract | Graphical Abstract Following syngeneic renal sub-capsule islet transplantation in C57/B6 mice, pulsed focused ultrasound improved the function of transplanted islets with diabetic animals rapidly re-establishing glycemic control. [Sci Rep] Full Article PANCREATIC CANCERALPPL2 Is a Potential Diagnostic Biomarker for Pancreatic Cancer Derived Extracellular Vesicles Investigators showed that alkaline phosphatase placental-like 2 (ALPPL2) was present in pancreatic cancer extracellular vesicles, and therefore has potential application in liquid biopsy-based diagnostic strategies. [Mol Ther Methods Clin Dev] Abstract | Full Article Researchers showed that family with sequence similarity 83 (FAM83) expression was significantly elevated in human and murine pancreatic cancers and was essential for the growth and tumorigenesis of pancreatic cancer cells. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSDiagnosis and Management of Pancreatic Cystic Neoplasms: Current Evidence and Guidelines Scientists summarize the latest developments in the diagnosis and management of pancreatic cystic neoplasms, including the quality of available evidence. [Nat Rev Gastroenterol Hepatol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSTonix Pharmaceuticals Holding Corp. announced that it has obtained an exclusive license from Columbia University for the development of TNX-1700 for the treatment of gastric and pancreatic cancers. [Tonix Pharmaceuticals Holding Corp.] Press Release Rafael Pharmaceuticals, Inc. announced the expansion of its Phase III clinical trial for patients with metastatic pancreatic cancer into France. [Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSNew Deals Could Help Scientific Societies Survive Open Access A project that included funders backing Plan S, the European-led effort to speed the transition to open access, released a set of contract templates and tips meant to help small, independent publishers reach deals with libraries that would eventually eliminate subscriptions while protecting revenue. [ScienceInsider] Editorial Trump’s Top Scientist Outlines Plan to Reduce Foreign Influence on US Research After months of outcry over whether the United States government is unfairly targeting foreign-born researchers over purported security breaches, President Donald Trump’s science adviser is launching an effort to strengthen national policies on research security. [Nature News] Editorial Science under Maximum Pressure in Iran From travel restrictions and publishing bans to currency collapse, the restoration of US sanctions has left researchers in Iran reeling. [The Scientist] Editorial
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EVENTSNEW Cancer Epigenetics: New Mechanisms and Therapeutic Opportunities Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Position – Cancer Biology (Children’s Research Institute at UT Southwestern) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Postdoctoral Fellow – Pancreatic Cancer (The University of Alabama at Birmingham) Postdoctoral Position – Pancreatic Ductal Adenocarcinoma (IT University of Copenhagen) Lab Aide – Pancreatic Cancer Research (Fred Hutchinson Cancer Research Center) Research Technition – Diabetes, Allergies, and Lung Diseases (Helmholtz Zentrum München) Postdoctoral Researcher – Auto-Immunity (Benaroya Research Institute) Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Postdoctoral Fellow – Neuroscience and Diabetes (The Child Health Institute of New Jersey) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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