Pancreatic Cell News Volume 10.46 | Nov 26 2019

TOP STORY

Chemotherapy Impacts on the Cellular Response to CDK4/6 Inhibition: Distinct Mechanisms of Interaction and Efficacy in Models of Pancreatic Cancer

Investigators demonstrated that the difference in mechanisms of actions of chemotherapeutic agents elicited distinct effects on the cellular response to CDK4/6 inhibition. Gemcitabine largely ablated the function of CDK4/6 inhibition in S-phase arrested cells when administered contemporaneously. [Oncogene] Abstract

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DIABETES & PANCREATITIS

miR-132 Controls Pancreatic Beta Cell Proliferation and Survival through the Pten/Akt/Foxo3 Signaling

RNA from laser capture microdissected islets of partially pancreatectomized and sham-operated mice were profiled with microarrays to identify putative miRNAs implicated in beta cell regeneration. [Mol Metab] Full Article

In Situ Analysis Reveals That CFTR Is Expressed in Only a Small Minority of β-Cells in Normal Adult Human Pancreas

CFTR mRNA was detectable in 0.45% (mean) of insulin-positive cells. CFTR protein expression was co-localized with Keratin-7. 100% of insulin-positive cells were immunonegative for CFTR. [J Clin Endocrinol Metab] Abstract

miR-221/222 Inhibit Insulin Production of Pancreatic β-Cells in Mice

Adenovirus-mediated overexpression of miR-221/222 was performed on β-cells and MIN6 cells to explore the effect and mechanisms of miR-221/222 on β-cell proliferation and functions. [Endocrinology] Abstract

Kisspeptin-Activated Autophagy Independently Suppresses Non-Glucose-Stimulated Insulin Secretion from Pancreatic β-Cells

To investigate the involvement of autophagy in kisspeptin-regulated insulin secretion, researchers overexpressed Kiss1 in NIT-1 cells to mimic the long-term exposure of pancreatic β-cells to kisspeptin during type 2 diabetes. [Sci Rep] Full Article

PANCREATIC CANCER

Deficiency of the Adrenomedullin-RAMP3 System Suppresses Metastasis through the Modification of Cancer-Associated Fibroblasts

The authors investigated the actions of the adrenomedullin-receptor activity-modifying protein-2 and -3 systems in the tumor microenvironment and their impact on metastasis. PAN02 pancreatic cancer cells were injected into the spleens of mice, leading to spontaneous liver metastasis. [Oncogene] Abstract

Oncogenic Role of TYRO3 Receptor Tyrosine Kinase in the Progression of Pancreatic Cancer

The authors confirmed TYRO3 expression in five human pancreatic cancer cell lines using Western blotting. They showed that tumor growth was significantly suppressed in mice subcutaneously inoculated with TYRO3-knockdown pancreatic cancer cells compared with mice inoculated with control pancreatic cancer cells. [Cancer Lett] Abstract

Dynamic Palmitoylation Controls the Microdomain Localization of the DKK1 Receptors CKAP4 and LRP6

Scientists found that both cytoskeleton-associated protein (CKAP)4 and lipoprotein receptor-related protein 6 primarily localized to detergent-resistant membrane fractions of the plasma membrane in a palmitoylation-dependent manner and that palmitoylation of CKAP4 was required for it to promote cell proliferation. [Sci Signal] Abstract

Inhibition of PTP1B Blocks Pancreatic Cancer Progression by Targeting the PKM2/AMPK/mTOC1 Pathway

Inhibition of protein-tyrosine phosphatase 1B either by shRNA or by a specific small-molecule inhibitor significantly suppressed pancreatic cancer cell growth, migration and colony formation with cell cycle arrest in vitro and inhibited pancreatic cancer progression in vivo. [Cell Death Dis] Full Article

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Pancreatic Islet Transcriptional Enhancers and Diabetes

Common genetic variants that associate with type 2 diabetes risk are markedly enriched in pancreatic islet transcriptional enhancers. Scientists discuss current advances in the annotation of islet enhancer variants and their target genes. [Curr Diab Rep] Full Article

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Chi-Med Announces Surufatinib Granted FDA Orphan Drug Designation for Pancreatic Neuroendocrine Tumors

Hutchison China MediTech Limited (Chi-Med) announced that the FDA has granted orphan drug designation to surufatinib for the treatment of pancreatic neuroendocrine tumors. If approved by the FDA as an orphan treatment, surufatinib will be entitled to seven years of market exclusivity for the approved indication. [Hutchison China MediTech Limited] Press Release

Poxel Announces Positive Topline Results for Imeglimin Phase III Trial for the Treatment of Type 2 Diabetes in Japan

POXEL SA announced positive topline Phase III results from the 36-week, open-label extension period of the TIMES 3 trial, which evaluated imeglimin in combination with insulin for the treatment of type 2 diabetes. [Poxel SA] Press Release

Five Ways China Must Cultivate Research Integrity

A swift increase in scientific productivity has outstripped the country’s ability to promote rigour and curb academic misconduct; it is time to seize solutions. [Nature News] Editorial

Elsevier Signs First Open-Access Deal in the United States

Publishing giant Elsevier has signed its first open-access deal with a US institution, Carnegie Mellon University (CMU) in Pittsburgh, Pennsylvania, Inside Higher Ed reports. The arrangement, which CMU announced on 21 November, will allow CMU scholars to publish articles in any Elsevier journal on an immediately free-to-read basis. [ScienceInsider] Editorial

NEW Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies
January 9-12, 2020
San Diego, California, United States

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NEW Postdoctoral Position – Cellular Signaling Mechanisms in Pancreatic Ductal Adenocarcinoma (Universitätsklinikum Freiburg)

Research Technician – Cell Engineering in Diabetes (Helmholtz Zentrum München)

Postdoctoral Position – Pancreatic Cancer Bioinformatics (University of Copenhagen)

Postdoctoral Associate – Targeting Altered RNA Processing Mechanisms in Pancreatic Cancer (Yale University)

Postdoctoral Studentship – Pancreatic Cancer Immunology/Bioinformatics (Heidelberg University Hospital)

Postdoctoral Scholar – Pancreatic Cancer Cell Research (University Hospitals Cleveland Medical Center)

Postdoctoral Researcher – Islet Biology, Stem Cells and Regenerative Medicine (University of Geneva)

Postdoctoral Fellow – Type I Diabetes Research (German Research Center for Environmental Health)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Postdoctoral Fellowship – Regenerative Medicine and Metabolic Biology (Indiana Biosciences Research Institute)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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