Pancreatic Cell News 10.47 December 3, 2019 | |
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TOP STORYCharacterization of Genetic Subclonal Evolution in Pancreatic Cancer Mouse Models Scientists report evidence of continuing subclonal evolution after tumor initiation that largely reflected copy number alterations that targeted cellular processes of established significance in human pancreatic cancer. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISInvestigators examined seipin expression in islet cells and measured glucose profiles, insulin synthesis, glucose-stimulated insulin secretion, islet expression of peroxisome proliferator-activated receptor γ (PPARγ), and beta cell mass and proliferation in male and female Seipin-knockout homozygous and heterozygous mice. [Diabetologia] Abstract Human islets, were treated in vitro with known cytochrome P450 (CYP)1A inducers 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3-methylcholanthrene. In addition, mice were injected with either a single high dose of TCDD or multiple low doses of TCDD in vivo, and islets were isolated 1, 7 or 14 days later. [Diabetologia] Abstract Abnormal Regulation of Glucagon Secretion by Human Islet Alpha Cells in the Absence of Beta Cells Highly purified human α-cells from islets of deceased donors were re-aggregated in the presence or absence of β-cells in culture, evaluated for glucagon secretion under various treatment conditions, and compared to that of intact human islets and non-sorted islet cell aggregates. [EBioMedicine] Abstract | Full Article Macrophage-Associated Pro-Inflammatory State in Human Islets from Obese Individuals The authors showed that pro-inflammatory cytokines (IL-1β, IL-6, and TNF), anti-inflammatory cytokines (IL-10 and TGF-β) and macrophage polarization markers (CD11c, CD163, and NOS2) were expressed in isolated human islets from non-diabetic donors. [Nutr Diabetes] Full Article PANCREATIC CANCERParaneoplastic β Cell Dedifferentiation in Non-Diabetic Patients with Pancreatic Cancer Researchers examined pancreatic islets from 15 non-diabetic patients with benign tumor and 15 non-diabetic pancreatic ductal adenocarcinoma patients. They calculated the number of hormone-negative endocrine cells and evaluated important markers of β cell dedifferentiation and function in the paraneoplastic islets. [J Clin Endocrinol Metab] Abstract Branched-Chain Amino Acids Sustain Pancreatic Cancer Growth by Regulating Lipid Metabolism The authors found that branched-chain amino acid (BCAA) metabolism had an important role in human pancreatic ductal adenocarcinoma growth by regulating lipogenesis. Compared with nontransformed human pancreatic ductal cells, pancreatic ductal adenocarcinoma growth cells exhibited significantly elevated BCAA uptake through solute carrier transporters. [Exp Mol Med] Full Article Novel Therapeutic Approach Using Drug-Loaded Adipose-Derived Stem Cells for Pancreatic Cancer Scientists confirmed that pirarubicin was gradually released into the culture medium from pirarubicin-conjugated polylactic/glycolic acid nanoparticles-loaded adipose-derived stem cells, and the conditioned medium significantly inhibited the proliferation activity and induced the apoptosis of human pancreatic cancer cells. [Sci Rep] Full Article Researchers examined the role of non-SMC condensin I complex subunit H (NCAPH) in pancreatic cancer cells. Their results showed that NCAPH was overexpressed in clinical pancreatic cancer specimens and cell lines. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSRole of the Microbiome in Occurrence, Development and Treatment of Pancreatic Cancer Scientists discuss the mechanisms through which microbiomes affect the development of pancreatic cancer, including inflammation and immunomodulation. Potential therapeutic and diagnostic applications of microbiomes are also discussed. [Mol Cancer] Full Article Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSEI and the HSE Award Five Firms Funding to Address Challenges Related to Diabetes Enterprise Ireland and the Health Service Executive (HSE) have awarded €100,000 in funding to five companies tackling health complications that arise as a result of diabetes. The funding was awarded through Enterprise Ireland’s Small Business Innovation Research programme. [Siliconrepublic] Press Release LI Lab Wins $750,000 Grant to Advance Cancer Research Cold Spring Harbor Laboratory announced that it has been awarded $750,000 from TD Bank to support its new cancer research facility. The award is part of the Toronto-based bank’s initiative to provide financial support to organizations that have designed solutions to improve access to early detection and intervention for diseases. [Cold Spring Harbor Laboratory (Newsday)] Press Release | |
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POLICY NEWSElsevier Progresses in Open-Access Deal Making The scholarly publisher has announced several new licensing agreements in both Europe and the US, but some major academic groups are still without contracts and access to journals. [The Scientist] Editorial Chinese Ministry Investigates Duplications in Papers by University President The Chinese education ministry is investigating scientific articles authored by high-profile immunologist and university president Cao Xuetao, following suggestions that dozens of papers contain potentially problematic images. Four journals also say they are examining papers from Cao. [Nature News] Editorial
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EVENTSNEW Keystone Symposia: Noncoding RNAs – Mechanism, Function and Therapies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESResearch Technician – Cell Engineering in Diabetes (Helmholtz Zentrum München) Postdoctoral Position – Pancreatic Cancer Bioinformatics (University of Copenhagen) Postdoctoral Researcher – Islet Biology, Stem Cells and Regenerative Medicine (University of Geneva) Postdoctoral Fellow – Type I Diabetes Research (German Research Center for Environmental Health) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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