Pancreatic Cell News Volume 10.49 | Dec 17 2019

TOP STORY

Glucose Homeostasis Is Regulated by Pancreatic β-Cell Cilia via Endosomal EphA-Processing

Scientists ablated cilia from mature β-cells by deleting key cilia component Ift88. They report that glucose homeostasis and insulin secretion deteriorated over 12 weeks post-induction. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

IgGs from Patients with Amyotrophic Lateral Sclerosis and Diabetes Target CaVα2δ1 Subunits Impairing Islet Cell Function and Survival

Researchers demonstrated that 60% of amyotrophic lateral sclerosis patients with type 2 diabetes mellitus haved sera that exaggerated K⁺-induced increases in cytosolic free Ca²⁺ concentration in mouse islet cells. [Proc Natl Acad Sci USA] Full Article

Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes

Investigators demonstrated that human stem cell-derived islets reaggregated from cryopreserved cells displayed glucose-stimulated insulin secretion in vitro. [Stem Cell Reports] Full Article

Islet Macrophages Shift to a Reparative State Following Pancreatic Beta-Cell Death and Are a Major Source of Islet IGF-1

The authors found that following streptozotocin-induced beta-cell death, mouse islet macrophages expressed increased Igf1, decreased proinflammatory cytokine expression, and transcriptome changes consistent with macrophages undergoing efferocytosis and having an enhanced state of metabolism. [iScience] Abstract

PANCREATIC CANCER

Transcription Factor NFAT5 Contributes to the Glycolytic Phenotype Rewiring and Pancreatic Cancer Progression via Transcription of PGK1

Scientists explored the impact of Nuclear Factor of Activated T Cells 5 (NFAT5) on the biological behavior of pancreatic ductal adenocarcinoma and the underlying mechanism. [Cell Death Dis] Full Article

Ultrasound-Induced Cavitation Enhances the Efficacy of Chemotherapy in a 3D Model of Pancreatic Ductal Adenocarcinoma with Its Microenvironment

Coculture spheroids combining DT66066 cells isolated from KPC-transgenic mice and murine embryonic fibroblasts were obtained by using a magneticnanoshuttle method. Spheroids were exposed to ultrasound with incremental inertial cavitation indexes. [Sci Rep] Full Article

A Genome-Scale CRISPR/Cas9 Knockout Screening Reveals SH3D21 as a Sensitizer for Gemcitabine

Researchers performed a genome-scale CRISPR/Cas9 knockout screening on pancreatic cancer cell line Panc1 to explore the genes that were important for gemcitabine efficacy. [Sci Rep] Full Article

TIMP-2 Secreted by Monocyte-Like Cells Is a Potent Suppressor of Invadopodia Formation in Pancreatic Cancer Cells

Two pancreatic ductal adenocarcinoma cell lines were selected on their ability to form invasive adhesions, otherwise known as invadopodia and invade in a spheroid invasion assay. [BMC Cancer] Full Article

Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti‐Austerity Activity against Human PANC-1 Pancreatic Cancer Cells

Investigators report the synthesis and biological evaluation of racemic analogues of grandifloracin bearing diverse sidechains, of which two showed enhanced potency in comparison with the natural product. [ChemMedChem] Full Article

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New Frontiers in the Treatment of Type 1 Diabetes

The authors discuss successes, failures, and emerging pharmacological therapies for type 1 diabetes that are changing how researchers approach this disease, from improving glycemic control to developing the “holy grail” of disease prevention. [Cell Metab] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

Helix BioPharma Corp. Commences L-DOS47 Phase Ib/II Pancreatic Cancer Clinical Study

Helix BioPharma Corp. announced the start of enrollment and screening in the Company’s Phase Ib/II clinical development program for previously treated patients with advanced pancreatic cancer. [Helix BioPharma Corp. (GlobeNewswire, Inc.)] Press Release

PharmaCyte Biotech Finalizes Pancreatic Cancer Treatment for US FDA Approval to Begin Clinical Trial

PharmaCyte Biotech has a clinical trial product, a clinical trial protocol, including a clinical trial design, a Principal Investigator, and the company is ready to present its treatment for locally advanced, inoperable pancreatic cancer to the US FDA in an effort to secure approval to begin a Phase IIb clinical trial in locally advanced, inoperable pancreatic cancer. [PharmaCyte Biotech, Inc. (GlobeNewswire, Inc.)] Press Release

UK Election Dashes Scientists’ Hopes of Staying in the EU

The United Kingdom is now firmly on the path towards leaving the European Union, after the Conservative party won a majority of 79 seats in yesterday’s general election – a result that has major implications for science. [Nature News] Editorial

United States Drops Charges against Two More Scientists after Iran Prisoner Swap

US authorities have dropped charges against two researchers accused of attempting to export chemicals to Iran in violation of trade sanctions. The decision follows a prisoner swap in which the United States freed a third researcher who was charged alongside them – and imprisoned. [Nature News] Editorial

NEW 3^rd Global NASH Congress
February 10-11, 2020
London, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow Positions – Genetics and Diabetes (University of Pennsylvania)

NEW Postdoctoral Researchers – Cell Biology (Karolinska Institutet)

Postdoctoral Fellowship – Cellular Fate in the Developing Pancreas (University of Copenhagen)

Postdoctoral Fellowship – Transcriptional Plasticity of the Endocrine Pancreas (University of Southern Denmark)

Postdoctoral Position – Cellular Signaling Mechanisms in Pancreatic Ductal Adenocarcinoma (Universitätsklinikum Freiburg)

Research Technician – Cell Engineering in Diabetes (Helmholtz Zentrum München)

Postdoctoral Position – Pancreatic Cancer Bioinformatics (University of Copenhagen)

Postdoctoral Associate – Targeting Altered RNA Processing Mechanisms in Pancreatic Cancer (Yale University)

Postdoctoral Studentship – Pancreatic Cancer Immunology/Bioinformatics (Heidelberg University Hospital)

Postdoctoral Scholar – Pancreatic Cancer Cell Research (University Hospitals Cleveland Medical Center)

Postdoctoral Researcher – Islet Biology, Stem Cells and Regenerative Medicine (University of Geneva)

Postdoctoral Fellow – Type I Diabetes Research (German Research Center for Environmental Health)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Postdoctoral Fellowship – Regenerative Medicine and Metabolic Biology (Indiana Biosciences Research Institute)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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