Pancreatic Cell News 11.02 January 21, 2020 | |
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TOP STORYThe authors investigated the supportive effects of cotransplanting islets and perivascular mesenchymal stromal cells isolated from human umbilical cords (HUCPVCs). The HUCPVCs inhibited T cells and expressed proregenerative and immunoregulatory markers in vitro and increased islet vascularization in vivo. [Sci Transl Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISGenomic Programming of IRF4-Expressing Human Langerhans Cells Bulk and single-cell transcriptional profiling demonstrated that human migratory Langerhans cells were robustly programmed for MHC-I and MHC-II antigen presentation. [Nat Commun] Full Article Irp2 Regulates Insulin Production through Iron-Mediated Cdkal1-Catalyzed tRNA Modification Iron-regulatory protein 2 (Irp2) post-transcriptionally regulated the iron-uptake protein transferrin receptor 1 and the iron-storage protein ferritin, and dysregulation of these proteins due to Irp2 loss caused functional iron deficiency in β cells. [Nat Commun] Full Article Scientists used next-generation sequencing to detect the miRNA expression profile of normal mouse pancreatic β-cells, non-β-cells, bone marrow mesenchymal stem cells and adipose-derived stem cells and determined relative miRNA expression levels in mouse pancreatic β-cells. [Mol Ther Nucleic Acids] Abstract | Full Article Somatostatin Secretion by Na+-Dependent Ca2+-Induced Ca2+ Release in Pancreatic Delta Cells Investigators showed that dapagliflozin-sensitive glucose- and insulin-dependent sodium uptake stimulated somatostatin secretion by elevating the cytoplasmic Na+ concentration and promoting intracellular Ca2+-induced Ca2+ release. [Nat Metab] Abstract PANCREATIC CANCERNEDD4L Downregulates Autophagy and Cell Growth by Modulating ULK1 and a Glutamine Transporter Researchers showed that NEDD4L, an E3 ubiquitin ligase, bound ULK1 in pancreatic cancer cells. ULK1 expression was stabilized in NEDD4L knockdown cells compared to that in control cells, suggesting that NEDD4L was involved in ULK1 ubiquitination and its subsequent degradation. [Cell Death Dis] Full Article Scientists investigated dose-dependent irradiation effects on clonogenic survival, expression of immunologically relevant cell surface molecules and susceptibility to cytotoxic T cell mediated killing using a murine pancreatic ductal adenocarcinoma cell line. [Sci Rep] Full Article Investigators showed that mechanical changes in the pancreatic cancer cell environment affected not only adhesion and migration, but also ATP/ADP and ATP/AMP ratios. [Nat Metab] Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSThe Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes The author discusses the possible causes of the abnormal glucagonemia in diabetes, with particular emphasis on type 2 diabetes, and briefly comments on the current anti-diabetic therapies affecting α-cells. [J Mol Biol] Abstract | Graphical Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSHutchison China MediTech Limited announced that the independent Data Monitoring Committee of the Phase III pivotal study of surufatinib in advanced neuroendocrine tumors – pancreatic has completed a pre-planned interim analysis. [Hutchison China MediTech Limited] Press Release PharmaCyte Biotech continues to move toward a planned Phase IIb clinical trial in locally advanced, inoperable pancreatic cancer (LAPC) to address those patients who no longer see any benefit after being treated for four to six months with one of two first-line therapies for the disease. [PharmaCyte Biotech (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSCampus Attacks by Nationalists and Police Alarm India’s Scientific Community The attack on one of India’s most prestigious universities sent shock waves around the country and is the latest sign that the political forces tearing apart Indian society are also affecting the country’s academic community. Students at JNU, a liberal bastion, had been on strike for months against both a major hike in student fees and the government’s controversial Citizenship Amendment Act, widely decried as discriminatory against Muslims. [ScienceInsider] Editorial Moffitt Cancer Center Details Links of Fired Scientists to Chinese Talent Programs Six Florida cancer researchers who were dismissed last month for hiding their ties to a Chinese medical university appear to have been motivated by simple greed and a disregard for both institutional and federal rules. [ScienceInsider] Editorial
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EVENTSNEW 2nd Epigenetics Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – RNA Cancer Biology and Diabetes (The Jackson Laboratory) NEW Postdoctoral Fellowship – Diabetes and Kidney Diseases (National Institutes of Health) Postdoctoral Research Fellow – Endocrinology and Diabetes (Cedars-Sinai Medical Center) Postdoctoral Fellow – Elevated Androgen in Type 2 Diabetes (Temple University) Postdoctoral Associate Position – Proteomics and Immunoproteomics in Diabetes (Cornell University) Postdoctoral Fellow Positions – Genetics and Diabetes (University of Pennsylvania) Postdoctoral Fellowship – Cellular Fate in the Developing Pancreas (University of Copenhagen) Research Technician – Cell Engineering in Diabetes (Helmholtz Zentrum München) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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