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Pulmonary Cell News| Pancreatic Cell News 11.03 January 28, 2020 | |
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TOP STORYDynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer Researchers showed that reactive oxygen species (ROS) regulation by TIGAR supported premalignant tumor initiation while restricting metastasis. Increased ROS in pancreatic ductal adenocarcinoma cells drove a phenotypic switch that increased migration, invasion, and metastatic capacity. [Cancer Cell] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISKindlin-2 Modulates MafA and β-Catenin Expression to Regulate β-Cell Function and Mass in Mice Researchers showed that β-cells expressed abundant Kindlin-2 and deleting its expression caused severe diabetes-like phenotypes without markedly causing peripheral insulin resistance. [Nat Commun] Full Article The authors found that Vegfb was ubiquitously expressed throughout the pancreas, and that β-cell Vegfb deletion resulted in increased insulin gene expression. [Sci Rep] Full Article Toxicity of Fatty Acid Profiles of Popular Edible Oils in Human EndoC-βH1 Beta-Cells Scientists examined the toxicity of free fatty acid compositions mirroring the free fatty acid profiles of various popular edible oils in human EndoC-βH1 beta-cells and in rat islets. [Nutr Diabetes] Full Article PANCREATIC CANCERDifferential Dependency of Human Pancreatic Cancer Cells on Targeting PTEN via PLK 1 Expression The pancreatic cancer cells were divided into PTEN blockade-susceptible and PTEN blockade-impassible groups dependent on targeting PTEN by altering intracellular signaling. [Cancers] Full Article LyP-1-fMWNTs Enhanced Targeted Delivery of MBD1siRNA to Pancreatic Cancer Cells LyP-1-conjugated functionalized multi-walled carbon nanotubes were successfully synthesized, characterized and showed satisfactory size distribution and zeta potential. LyP-1-fMWNTs/MBD1siRNA complex could significantly decrease the viability and proliferation and promoted apoptosis of pancreatic cancer cells in vitro. [J Cell Mol Med] Full Article TP53/miR-34a-Associated Signaling Targets SERPINE1 Expression in Human Pancreatic Cancer Investigators examined the expression of 440 proteins on a reverse phase protein array in pancreatic ductal adenocarcinoma-derived MIA-PaCa-2 cells which either had WT-TP53 or lacked WT-TP53. [Aging (Albany NY)] Full Article Alkannin Represses Growth of Pancreatic Cancer Cells Based on the Down Regulation of miR-199a PANC-1 and MIN6 cells were treated by alkannin and its role was evaluated in cellular viability. Researchers assessed the ability of PANC-1 cells to proliferate, migrate, and invade as well as apoptosis process. [Biofactors] Abstract Scientists studied the role and regulatory mechanism of a G protein-coupled receptor named as G Protein-Coupled Receptor 87 (GPR87) in the expansion of pancreatic ductal adenocarcinoma stem cells. [Mol Ther Oncolytics] Abstract | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSPancreatic α-Cells – the Unsung Heroes in Islet Function The authors highlight α-cell regulation and glucagon secretion with a special focus on recent discoveries from human islets. They present some novel aspects of glucagon function and effects of selected glucose lowering agents on glucagon secretion. [Semin Cell Dev Biol] Full Article Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSBioLineRx, Ltd. announced the completion of patient recruitment in the triple combination arm of its ongoing Phase IIa COMBAT/KEYNOTE-202 study. [BioLineRx, Ltd.] Press Release PharmaCyte Biotech Successfully Completes All Release Tests on Clinical Trial Product PharmaCyte Biotech, Inc. announced that both batches of the company’s manufactured clinical trial product have undergone and passed all ten of the necessary “release tests” required by the FDA. [PharmaCyte Biotech, Inc.] Press Release | |
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POLICY NEWSBrazil’s Pick of a Creationist to Lead Its Higher Education Agency Rattles Scientists The appointment of a creationism advocate to lead the agency that oversees Brazil’s graduate study programs has scientists there concerned-yet again-about the encroachment of religion on science and education policy. President Jair Bolsonaro’s administration on Saturday January 25th named Benedito Guimarães Aguiar Neto to head the agency, known as CAPES, who previously served as the rector for a private religious school which advocates the teaching and study of intelligent design. [ScienceInsider] Editorial US Officials Revisit Rules for Disclosing Risky Disease Experiments US disease researchers are pushing the government to be more transparent about federally funded research that involves making pathogens more deadly or more transmissible. Several disease researchers who attended a recent meeting to discuss transparency around such studies say the US government should offer a public explanation when it approves such ‘gain-of-function’ experiments, disclose who made the decision to fund them and make a broad public announcement when a study begins. [Nature News] Editorial Wuhan Scientists: What It’s Like to Be on Lockdown Chinese authorities have closed off travel into and out of the virus-hit city of Wuhan in an attempt to stop the outbreak’s spread. Nature spoke to three researchers about what it’s like to be inside Wuhan right now – and talked to one who is trying to get back in. [Nature News] Editorial Animal Rights Conflict Prompts Leading Researcher to Leave Germany for China A prominent neuroscientist whose German lab was targeted by animal rights activists is heading to China, where he says he will be freer to pursue his work on macaques and other monkeys. Nikos Logothetis, a director at the Max Planck Institute for Biological Cybernetics in Tübingen, Germany, told colleagues last week that the first members of his lab would move in the coming months to a new International Center for Primate Brain Research in Shanghai. [ScienceInsider] Editorial
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EVENTSNEW American Association for Cancer Research (AACR) Meeting: The Evolving Landscape of Cancer Modeling NEW 3rd IPITA/JDRF/HSCI Conference on Stem Cell Derived Beta Cells Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Diabetes (Harvard Joslin Diabetes Center) Postdoctoral Associate – RNA Cancer Biology and Diabetes (The Jackson Laboratory) Postdoctoral Fellowship – Diabetes and Kidney Diseases (National Institutes of Health) Postdoctoral Research Fellow – Endocrinology and Diabetes (Cedars-Sinai Medical Center) Postdoctoral Fellow – Elevated Androgen in Type 2 Diabetes (Temple University) Postdoctoral Associate Position – Proteomics and Immunoproteomics in Diabetes (Cornell University) Postdoctoral Fellow Positions – Genetics and Diabetes (University of Pennsylvania) Postdoctoral Fellowship – Cellular Fate in the Developing Pancreas (University of Copenhagen) Research Technician – Cell Engineering in Diabetes (Helmholtz Zentrum München) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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