Pancreatic Cell News Volume 11.04 | Feb 04 2020

TOP STORY

The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma

The authors showed that pancreatic intra- epithelial neoplasia driven by oncogenic mutant Kras G12D progressed to pancreatic adenocarcinoma in the absence of BAP1. [Cancer Res] Abstract

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Goldfish Adipocytes Are Pancreatic Beta Cell-Like, Glucose-Responsive Insulin-Producing Cells

Scientists characterized goldfish adipocytes as cells with properties similar to that of pancreatic β-cells, which expressed considerably high levels of preproinsulin mRNAs, and possessed the necessary machinery for processing preproinsulin. [J Cell Physiol] Abstract

Group II p21-Activated Kinase, PAK4, Is Needed for Activation of Focal Adhesion Kinases, Mapk, PI3K/Akt, GSK3 and β-Catenin in Pancreatic Acinar Cells

Researchers examined the role of p21-activated kinase’s participation in five different CCK-8-stimulated signaling pathways, which mediated many of its physiological acinar-cell effects and effects in pathophysiological conditions. [Am J Physiol Gastrointest Liver Physiol] Abstract

Adrenomedullin Has a Cytoprotective Role against ER Stress for Pancreatic β-Cells in Autocrine and Paracrine Manners

Investigators analyzed adrenomedullin expression in islet cell lines treated with pioglitazone. To study the anti-apoptotic effect of adrenomedullin, ER stress-exposed MIN6 cells were treated with adrenomedullin peptides or transfected with adrenomedullin expression plasmid. [J Diabetes Investig] Abstract

PANCREATIC CANCER

Endocytosis of ATB^0,+(SLC6A14)-Targeted Liposomes for Drug Delivery and Its Therapeutic Application for Pancreatic Cancer

The uptake of lysine-conjugated liposomes was greater in ATB^0,+-positive MCF7 cells. The uptake process consisted of two steps: binding and internalization. [Expert Opin Drug Deliv] Abstract

PTBP3 Promotes Malignancy and Hypoxia-Induced Chemoresistance in Pancreatic Cancer Cells by ATG12 Up-Regulation

Scientists investigated the role of polypyrimidine tract-binding protein 3 (PTBP3) in tumor development and chemotherapeutic resistance in human pancreatic ductal adenocarcinoma tissues and pancreatic cancer cells. [J Cell Mol Med] Full Article

Generation and Characterization of a Cell Line from an Intraductal Tubulopapillary Neoplasm of the Pancreas

The authors report the generation and characterization of a cell line from a human pancreatic intraductal tubulopapillary neoplasm. Neoplastic cells were initially cultured in a three-dimensional organoid system, followed by transfer to two-dimensional culture. [Lab Invest] Abstract

KANSL2 and MBNL3 Are Regulators of Pancreatic Ductal Adenocarcinoma Invasion

Investigators used CRISPR screening to identify genes that strongly regulated invasion, based on an in vitro assessment of their metastatic potential, in PANC-1, a pancreatic ductal adenocarcinoma cell line. [Sci Rep] Full Article

Application of Non-Invasive Low-Intensity Pulsed Electric Field with Thermal Cycling-Hyperthermia for Synergistically Enhanced Anticancer Effect of Chlorogenic Acid on PANC-1 Cells

Researchers investigated the efficacy of triple combination in PANC-1 cancer cells by adopting low-intensity pulsed electric field to couple with thermal-cycling hyperthermia and chlorogenic acid. [PLoS One] Full Article

FAM172A Inhibits EMT in Pancreatic Cancer via ERK-MAPK Signaling

Scientists investigated the potential role and molecular mechanism of FAM172A in epithelial to mesenchymal transition (EMT) in both human clinical samples and pancreatic cancer cells. [Biol Open] Abstract | Full Article

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Role of Oncogenic KRAS in the Diagnosis, Prognosis and Treatment of Pancreatic Cancer

Clinical studies have revealed that a KRAS mutation assay in fine-needle aspiration material combined with cytopathology increases the sensitivity, accuracy and negative predictive value of cytopathology for a positive diagnosis of pancreatic cancer. [Nat Rev Gastroenterol Hepatol] Abstract

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Theraly Fibrosis Awarded $3.9 Million SBIR Phase II Grant to Support Development of TLY012 for Chronic Pancreatitis

Theraly Fibrosis, a preclinical-stage biotechnology company focused on development and commercialization of drugs for various fibrotic diseases announced the company has been awarded a Small Business Innovation Research (SBIR) Phase II grant by the National Institutes of Health (NIH) in the amount of $3.9 million to support development of TLY012 for treatment of chronic pancreatitis. [Theraly Fibrosis (Businesswire, Inc.)] Press Release

AVEO Oncology and Biodesix Announce Results from Phase Ib Study of Ficlatuzumab, Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Cancer

AVEO Oncology and Biodesix, Inc. announced the presentation of results from an investigator-sponsored Phase Ib trial of ficlatuzumab, AVEO’s potent hepatocyte growth factor inhibitory antibody product candidate, in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic ductal adenocarcinoma. [AVEO Oncology, Inc.] Press Release

Why Did a Chinese University Hire Charles Lieber to Do Battery Research?

Among the ongoing mysteries surrounding last week’s arrest of Harvard University nanoscientist Charles Lieber is the precise nature of the research program Lieber was conducting in his cooperation with Chinese researchers. [ScienceInsider] Editorial

US Prosecutor Leading China Probe Explains Effort That Led to Charges against Harvard Chemist

The US government isn’t prosecuting Charles Lieber because he’s a world-renowned inorganic chemist at Harvard University, says the US attorney who last week drew headlines by charging Lieber with making false statements about his ties to Chinese research institutions. Nor does the Department of Justice think for one minute that Lieber is a spy. [ScienceInsider] Editorial

Cash from Cannabis Companies Creates Conflicted Researchers

Imagine that scientists charged with doing research on tobacco’s health implications were funded by tobacco companies. In fact, the tobacco industry used this tactic for decades to cast doubt on the adverse health effects of smoking. But today it would be an outrageous conflict of interest – research on addictive drugs shouldn’t be paid for by people who stand to profit from selling them. Yet this is exactly what is happening with cannabis. [STAT News] Editorial

NEW 3^rd IPITA/JDRF/HSCI Conference on Stem Cell Derived Beta Cells
April 21-22, 2020
Boston, Massachusetts, United States

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NEW Postdoctoral Fellow – Cancer Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Diabetes (Harvard Joslin Diabetes Center)

Postdoctoral Associate – RNA Cancer Biology and Diabetes (The Jackson Laboratory)

Postdoctoral Fellowship – Diabetes and Kidney Diseases (National Institutes of Health)

Postdoctoral Research Fellow – Endocrinology and Diabetes (Cedars-Sinai Medical Center)

Postdoctoral Research Fellow – Novel Drivers of Pancreatic Cancer (H. Lee Moffitt Cancer Center & Research Institute)

Postdoctoral Fellow – Elevated Androgen in Type 2 Diabetes (Temple University)

Postdoctoral Associate Position – Proteomics and Immunoproteomics in Diabetes (Cornell University)

Postdoctoral Fellow Positions – Genetics and Diabetes (University of Pennsylvania)

Postdoctoral Fellowship – Cellular Fate in the Developing Pancreas (University of Copenhagen)

Research Technician – Cell Engineering in Diabetes (Helmholtz Zentrum München)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Postdoctoral Fellowship – Regenerative Medicine and Metabolic Biology (Indiana Biosciences Research Institute)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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