Pancreatic Cell News Volume 11.05 | Feb 11 2020

TOP STORY

Multimodal Imaging Probe Development for Pancreatic β Cells: From Fluorescence to PET

Scientists developed a multimodal pancreatic β cell probe PiF for both fluorescence and for positron emission tomography (PET). By simple tail vein injection, PiF stained pancreatic β cells specifically and allowed intraoperative fluorescent imaging of pancreatic islets. [J Am Chem Soc] Abstract | Graphical Abstract

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DIABETES & PANCREATITIS

Shielding Islets with Human Amniotic Epithelial Cells Enhances Islet Engraftment and Revascularization in a Murine Diabetes Model

Shielded islets were generated on agarose microwells by mixing rat or human islets and human amniotic epithelial cells. Islet secretory function and viability were assessed after culture in hypoxia or normoxia in vitro. [Am J Transplant] Abstract

Mitochondrial Redox Signaling and Cristae Morphology Changes upon 2-Keto-Isocaproate and Fatty Acid-Stimulated Insulin Secretion

2-keto-isocaproate addition to INS-1E cells or pancreatic islets, in the absence of stimulatory concentrations of glucose, induced insulin secretion, which was prevented either by silencing of branched-chain α-ketoacid dehydrogenase E1α or by the mitochondrial antioxidant SkQ1. [Biophys J] Abstract

PANCREATIC CANCER

Cancer-Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma

Researchers studied three cancer-cell-derived matrisome proteins that were significantly over-represented during pancreatic ductal adenocarcinoma progression; agrin, serine protease inhibitor B5, and cystatin B. [Cancer Res] Abstract

Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib

Investigators discovered a dihydroquinolone pyrazoline-based molecule, 35d, which disrupted the RAD51-BRCA2 protein-protein interaction, thus mimicking the effect of BRCA2 mutation. 35d inhibited the homologous recombination in a human pancreatic adenocarcinoma cell line. [J Med Chem] Abstract

Aggregation of Chitosan Nanoparticles in Cell Culture: Reasons and Resolutions

The authors revisited the factors that influenced the stability of chitosan nanoparticles prepared with ionotropic gelation, widely recognized to be prone to aggregation, and proposed a model to overcome the negative influence of aggregation while testing in vitro efficacy [Int J Pharm] Abstract | Graphical Abstract

A Novel Derivative of Valepotriate Inhibits the PI3K/AKT Pathway and Causes Noxa-Dependent Apoptosis in Human Pancreatic Cancer Cells

The anti-proliferation activity of Amcp was validated in human pancreatic cancer BxPC-3 and SW1990 cells in vitro. Amcp more effectively induced apoptosis in BxPC-3 and SW1990 cells than gemcitabine. [Acta Pharmacol Sin] Abstract

EFNB2 Facilitates Cell Proliferation, Migration, and Invasion in Pancreatic Ductal Adenocarcinoma via the p53/p21 Pathway and EMT

To determine the underlying mechanisms of ephrin-2 (EFNB2), Investigators transfected pancreatic ductal adenocarcinoma cells with small interfering RNA and performed in vitro and in vivo experiments. [Biomed Pharmacother] Abstract | Graphical Abstract

Bitter Apricot Ethanolic Extract Induces Apoptosis through Increasing Expression of Bax/Bcl-2 Ratio and Caspase-3 in PANC-1 Pancreatic Cancer Cells

Researchers investigated the cyto/genotoxic effects of bitter apricot ethanolic extract and amygdalin on human pancreatic cancer PANC-1 and normal epithelial 293/KDR cells. [Mol Biol Rep] Abstract

Inhibition of Cholesterol Esterification Enzyme Enhances the Potency of Human Chimeric Antigen Receptor T Cells against Pancreatic Carcinoma

Scientists characterized the efficacy of modified chimeric antigen receptor T cells in terms of the cytotoxicity and cytokine release of both mesothelin-positive and mesothelin-negative pancreatic carcinoma cells using in vitro methods. [Mol Ther Oncolytics] Abstract

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Role of Imaging Biomarkers for Prognostic Prediction in Patients with Pancreatic Ductal Adenocarcinoma

The authors discuss the functions of imaging biomarkers for prognostic prediction in patients with pancreatic ductal adenocarcinoma and their potential value for further translation in clinical practice. [Clin Radiol] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

Elicio Therapeutics and Natera to Collaborate in Phase I/II Pancreatic Cancer Study of ELI-002

Elicio Therapeutics announced their collaboration in a prospective, multicenter Phase I/II study of ELI-002, an amphiphile immuno-oncology therapeutic targeting KRAS mutations in the adjuvant setting for patients with pancreatic ductal adenocarcinoma. [Elicio Therapeutics, Inc. (PR Newswire, Inc.)] Press Release

Provention Bio Highlights Critical New Research Studies on Type One Diabetes

Provention Bio, Inc. highlighted several new research studies on the increasing prevalence of type one diabetes and the importance of screening. [Provention Bio, Inc.] Press Release

VIVUS Receives US Food and Drug Administration Approval for Improved Formulation of PANCREAZE^® with a 36-Month Shelf Life

VIVUS, Inc. announced that the FDA has approved the supplemental New Drug Application for an improved formulation of PANCREAZE^® Delayed Release Capsules that extends the shelf life to 36 months across all PANCREAZE dosages. [VIVUS, Inc.] Press Release

Trump Proposes Significant Cuts to NIH for 2021 Budget

The president’s request for next year’s federal budget includes a seven percent drop in funding for the National Institutes of Health and reductions for other science agencies. [The Scientist] Editorial

Major Cancer Institute Sued by Its Own Researchers over ‘Tapering’ Funding

Alleging that a leading cancer funder is slashing their support in an “unethical and reckless” way, six prominent cancer researchers at the University of California, San Diego, have filed a lawsuit to compel it to continue its current level of support. [ScienceInsider] Editorial

NEW American Association for Cancer Research (AACR) Annual Meeting 2020
April 24-29, 2020
San Diego, California, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Studentship – Diabetes Epidemiology (Imperial College London)

Postdoctoral Fellow – Cancer Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Diabetes (Harvard Joslin Diabetes Center)

Postdoctoral Associate – RNA Cancer Biology and Diabetes (The Jackson Laboratory)

Postdoctoral Fellowship – Diabetes and Kidney Diseases (National Institutes of Health)

Postdoctoral Research Fellow – Endocrinology and Diabetes (Cedars-Sinai Medical Center)

Postdoctoral Research Fellow – Novel Drivers of Pancreatic Cancer (H. Lee Moffitt Cancer Center & Research Institute)

Postdoctoral Fellow – Elevated Androgen in Type 2 Diabetes (Temple University)

Postdoctoral Associate Position – Proteomics and Immunoproteomics in Diabetes (Cornell University)

Postdoctoral Fellowship – Cellular Fate in the Developing Pancreas (University of Copenhagen)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Postdoctoral Fellowship – Regenerative Medicine and Metabolic Biology (Indiana Biosciences Research Institute)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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