Pancreatic Cell News 11.06 February 18, 2020 | |
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TOP STORYGlucagon-like peptide-1 receptor (GLP1R) agonist-dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor synergy required combined inhibition of DYRK1A and an increase in cAMP and did not lead to β cell dedifferentiation. [Sci Transl Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISScientists showed that fast ultradian oscillations of the ligand Dll1 and the transcriptional effector Hes1 were crucial for MPC expansion, and changes in Hes1 oscillation parameters were associated with selective adoption of bipotent progenitor or unipotent pro-acinar cell fate. [Dev Cell] Full Article | Graphical Abstract Quantitative RT-PCR was used to evaluate the expression of several integrins and laminins in isolated neonatal rat islets in response to growth hormone and prolactin treatment. [Acta Physiol (Oxf)] Abstract Wolfram Syndrome 1 Gene Regulates Pathways Maintaining Beta-Cell Health and Survival Depletion of Wolfram syndrome 1 in vivo and in vitro caused functional defects in glucose-stimulated insulin secretion and insulin content, triggering Chop-mediated apoptotic pathways. [Lab Invest] Abstract Investigators report an expanded detection of single amino acid variants (SAAVs) in the PANC-1 cell line using three different strategies, which resulted in identification of 540 SAAVs in mass spectrometry data. [J Proteome Res] Abstract Intra-Islet GLP-1, but Not CCK, Is Necessary for β-Cell Function in Mouse and Human Islets Investigators tested whether islet-derived glucagon-like peptide 1 (GLP-1) or cholecystokinin (CCK) was necessary for the full stimulation of insulin secretion. [Sci Rep] Full Article The authors investigated whether so-called inducible subunits of the proteasome were constitutively expressed in β cells, regulated by inflammatory signals and participated in the formation of active intermediate or immuno-proteasomes. [PLoS One] Full Article Researchers showed that SNAP23, when depleted in mouse β cells in vivo and human β cells in vitro, paradoxically increased biphasic glucose-stimulated insulin secretion corresponding to increased exocytosis of predocked and newcomer insulin granules. [JCI Insight] Full Article PANCREATIC CANCERO-GlcNAcylation of PFKFB3 Is Required for Tumor Cell Proliferation under Hypoxia Scientists showed that the glycolytic regulator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3), which also promoted cell cycle progression in the nucleus, was O-GlcNAcylated in response to hypoxia. [Oncogenesis] Full Article Using shotgun proteomics researchers identified 363 proteins affected by nitroxoline treatment in AsPC-1 pancreatic cancer cells, including 81 consistently deregulated at both 24- and 48-hour treatment. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSThe authors describe the mitochondrial ion channels identified in pancreatic β-cells, and further discuss the possibility of targeting specific β-cell mitochondrial channels for the treatment of Type 2 diabetes. [Br J Pharmacol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSJDRF Reaches New Milestones in Work to Drive Cures for Type 1 Diabetes and Improve Lives JDRF funded $121.5 million directly and helped generate more than $400 million in total type 1 diabetes research funds from nonprofits, government, and industry to propel a year of remarkable breakthroughs in 2019. [JDRF] Press Release TriSalus Life Sciences announced the initiation of a new clinical trial assessing the safety and feasibility of an innovative new treatment that combines its intravascular, tumor-directed proprietary Pressure-Enabled Drug Delivery™ approach with standard of care systemic chemotherapy. [TriSalus Life Sciences (BusinessWire, Inc.)] Press Release | |
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POLICY NEWS‘The Disruption Is Enormous.’ Coronavirus Epidemic Snarls Science Worldwide Normal daily life has come to a virtual standstill in large parts of China as a result of the epidemic of COVID-19—and so has science. Universities across the country remain closed; access to labs is restricted, projects have been mothballed, field work interrupted, and travel severely curtailed. [ScienceInsider] Editorial Harvard, Yale Investigated for Undisclosed Foreign Funding The US Department of Education is investigating Harvard and Yale Universities for allegedly failing to disclose funds from other nations, according to a statement released February 12. First reported by the Wall Street Journal on Wednesday, the investigations are the latest in a series of efforts by the department to crack down on foreign influence in US institutions. [The Scientist] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Pancreatic Cancer (The University of Tennessee Health Science Center) NEW Postdoctoral Associate – Pancreatic Cancer Biology Research (University of Miami Health System) Postdoctoral Studentship – Diabetes Epidemiology (Imperial College London) Postdoctoral Fellow – Cancer Biology (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow – Diabetes (Harvard Joslin Diabetes Center) Postdoctoral Associate – RNA Cancer Biology and Diabetes (The Jackson Laboratory) Postdoctoral Fellowship – Diabetes and Kidney Diseases (National Institutes of Health) Postdoctoral Research Fellow – Endocrinology and Diabetes (Cedars-Sinai Medical Center) Postdoctoral Fellow – Elevated Androgen in Type 2 Diabetes (Temple University) Postdoctoral Associate Position – Proteomics and Immunoproteomics in Diabetes (Cornell University) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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