Pancreatic Cell News 11.08 March 3, 2020 | |
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TOP STORYCDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma Scientists report that sequential administration of CDK4/6 inhibitors after taxanes cooperated to prevent cellular proliferation in pancreatic ductal adenocarcinoma cells, patient-derived xenografts, and genetically engineered mice with Kras G12V and Cdkn2-null mutations. [Cancer Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISThe RB Gene Family Controls the Maturation State of the EndoC-βH2 Human Pancreatic β-Cells In EndoC-βH2 cells, the knock-down of RB itself, and, to a lesser extent, of its relative P130, precluded most events triggered by SV40LT depletion. [Differentiation] Abstract PANCREATIC CANCERConsidering the special tumor microenvironment of pancreatic ductal adenocarcinoma, researchers constructed a novel nanoparticle which was responsive to the membrane biomarker FAP-α on cancer-associated fibroblasts and near-infrared laser irradiation. [J Control Release] Abstract | Graphical Abstract Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition Investigators showed that in KRAS-driven murine pancreatic ductal adenocarcinoma cells, loss of Pten strongly enhanced both mTOR signaling and macropinocytosis. [Cell Rep] Full Article | Graphical Abstract MUC1 Oncoprotein Mitigates ER Stress via CDA-Mediated Reprogramming of Pyrimidine Metabolism MUC1 knockdown in pancreatic cancer cells enhanced unfolded protein response signaling and cell death upon ER stress induction. Transcriptomic analysis revealed alterations in the pyrimidine metabolic pathway and cytidine deaminase. [Oncogene] Abstract Increased dysbindin levels correlated with aggressive features in pancreatic ductal adenocarcinoma (PDAC), and the overexpression of dysbindin significantly promoted PDAC metastasis and invasion in vitro and in vivo. [Cancer Lett] Abstract Scientists indicated the importance of the noncanonical trans-acting HOTTIP-WDR5-MLL1 pathway in the HOTTIP regulatory mechanism by promoting oncogenic protein expression. [Cancer Lett] Abstract The authors showed that PROM2, a transmembrane glycoprotein, was ubiquitously upregulated in pancreatic cancer cells. They found that higher PROM2 expression was associated with shortened overall and disease-free survival times in patients diagnosed with pancreatic cancer. [Exp Mol Med] Full Article Modification of Radiosensitivity by Curcumin in Human Pancreatic Cancer Cell Lines Researchers evaluated the impact of curcumin on the radiosensitivity of the established human pancreatic cancer cell lines Panc-1 and MiaPaCa-2 in vitro. [Sci Rep] Full Article The effects of LINC00657 upregulation on pancreatic ductal adenocarcinoma cell proliferation, apoptosis, migration, and invasion in vitro and tumor growth in vivo were explored using CCK-8, flow cytometry, Transwell migration and invasion assays, and a xenograft tumor formation experiment. [Cell Cycle] Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSInsights Into Pancreatic Islet Cell Dysfunction from Type 2 Diabetes Mellitus Genetics The authors examine current human models that are used to study both β-cell development and function, including EndoC-β cell lines and human induced pluripotent stem cell-derived β-like cells. [Nat Rev Endocrinol] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSMPM Capital and Dana-Farber Cancer Institute have entered into a unique, first-of-its-kind, impact investing collaboration. The initiative partners fundraising for biotech venture capital investing with philanthropic fundraising for cancer research. [MPM Capital (BusinessWire, Inc.)] Press Release Tandem Diabetes Care, Inc. announced FDA clearance of its Basal-IQâ„¢ technology as an interoperable automated glycemic controller. [Tandem Diabetes Care, Inc. (BusinessWire, Inc.)] Press Release | |
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POLICY NEWSChina Bans Cash Rewards for Publishing Papers Chinese institutions have been told to stop paying researchers bonuses for publishing in journals, as part of a new national policy to cut perverse incentives that encourage scientists to publish lots of papers rather than focus on high-impact work. [Nature News] Editorial UC Santa Cruz Fires Graduate Students Taking Part in Strike The University of California, Santa Cruz, fired 54 graduate student employees from their teaching positions on February 28, in the latest escalation of a months-long dispute over student pay, the Santa Cruz Sentinel reports. [The Scientist] Editorial
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EVENTSNEW AACR Special Conference on Pancreatic Cancer Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowships – Pancreatic Disease (University of Copenhagen) Senior Scientist – Diabetes (International Institute of Innovation and Technology) Postdoctoral Fellow – Pancreatic Cancer (The University of Tennessee Health Science Center) Postdoctoral Associate – Pancreatic Cancer Biology Research (University of Miami Health System) Postdoctoral Studentship – Diabetes Epidemiology (Imperial College London) Postdoctoral Fellow – Cancer Biology (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow – Diabetes (Harvard Joslin Diabetes Center) Postdoctoral Associate – RNA Cancer Biology and Diabetes (The Jackson Laboratory) Postdoctoral Fellowship – Diabetes and Kidney Diseases (National Institutes of Health) Postdoctoral Research Fellow – Endocrinology and Diabetes (Cedars-Sinai Medical Center) Postdoctoral Associate Position – Proteomics and Immunoproteomics in Diabetes (Cornell University) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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