Pancreatic Cell News 11.09 March 10, 2020 | |
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TOP STORYThe MHC-II Peptidome of Pancreatic Islets Identifies Key Features of Autoimmune Peptides The proinsulin-derived peptides followed a trajectory from their generation and exocytosis in β cells to uptake and presentation in islets and peripheral sites. [Nat Immunol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISThe implanted islet-seeded biomaterial assembled into a solid organoid substructure that reorganized the extracellular matrix compartment and recruited endothelial progenitors for neovascularization. [Sci Rep] Full Article Microcystin-LR Impairs Glucose Metabolism in Pancreatic β Cells In Vivo and In Vitro Direct cytotoxic effects of microcystin-LR (MC-LR) were observed in the MIN6 pancreatic β-cells possibly due to their expression of the MC-LR specific transporter. [Toxicol Lett] Abstract Gangliosides Modulate Insulin Secretion by Pancreatic Beta-Cells under Glucose Stress Isolated beta cells from GM3 synthase null mice were unable to synthesize GM3 and GD3, and showed lower glucose uptake than respective control cells, corroborating the results obtained from the cell-specific model. [Glycobiology] Abstract Approved LXR Agonists Exert Unspecific Effects on Pancreatic β-Cell Function Scientists evaluated whether effects of novel agonist drugs on β-cell function were specific and reliably linked to liver-X-receptor (LXR) activation. [Endocrine] Full Article PANCREATIC CANCERCancer Associated Fibroblast FAK Regulates Malignant Cell Metabolism Researchers demonstrated that FAK-depletion in cancer-associated fibroblasts increased chemokine production, which via CCR1/CCR2 on cancer cells, activated protein kinase A. [Nat Commun] Full Article Laser-Assisted 3D Bioprinting of Exocrine Pancreas Spheroid Models for Cancer Initiation Study Investigators generated 3D pancreatic cell spheroid arrays using laser-assisted bioprinting and characterized their phenotypic evolution over time through image analysis and phenotypic characterization. [Biofabrication] Abstract Anti-Glypican-1 Antibody-Drug Conjugate Is a Potential Therapy against Pancreatic Cancer The authors measured the antitumor effect of anti-glypican-1 monoclonal antibody conjugated with the cytotoxic agent monomethyl auristatin F in vitro and in vivo. [Br J Cancer] Abstract Scientists report the feasibility of “immuno-OpenPET” as a novel approach enabling not only early diagnosis but also image-guided surgery, using a small resectable pancreatic cancer orthotopic xenograft mouse model. [Sci Rep] Full Article Uncovering Differently Expressed Markers and Heterogeneity on Human Pancreatic Cancer Researchers investigated the expression of seven markers related to the epithelial-to-mesenchymal transition on human pancreatic cancer tissue. [Transl Oncol] Full Article Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSNanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment Recent advances in nanotechnology have emerged as promising alternative strategies for the management of diabetes. The authors provide a holistic summary of this rapidly advancing field compiling all aspects pertaining to the management of diabetes. [Trends Endocrinol Metab] Abstract Dyslipidemia in Type 1 Diabetes: A Masked Danger Although the mechanisms underlying type 1 diabetes dyslipidemia remain unclear, the subcutaneous route of insulin administration, that is responsible for peripheral hyperinsulinemia, is likely to be an important factor. [Trends Endocrinol Metab] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSThe Pancreatic Cancer Collective Extends Four Research Teams in $16 Million Push for New Therapies The Pancreatic Cancer Collective has awarded additional funding of up to $16 million to four teams of top researchers as part of its “New Therapies Challenge Grants,” the American Association for Cancer Research, Scientific Partner of SU2C. [The Pancreatic Cancer Collective] Press Release Health Canada Approves Fast-Acting Mealtime Insulin, Fiasp®, for Children with Diabetes Fiasp® is now approved in Canada for pediatric patients aged two years and above giving Canadian families managing type 1 or type 2 diabetes an effective treatment option to support optimal mealtime glucose control. [Novo Nordisk Canada, Inc. (Newswire, Inc.)] Press Release FDA Proposes Broad Approach for Conducting Safety Trials for Type 2 Diabetes Medications The FDA issued a new draft guidance, “Type 2 Diabetes Mellitus: Evaluating the Safety of New Drugs for Improving Glycemic Control,” to solicit public comment on its proposals for broad safety evaluations before drug approval. [FDA] Press Release | |
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POLICY NEWSNew Trump Rules Aim to Fuel Sharing of Patient Health Records by Smartphone President Trump’s top health care aides said they will finalize federal rules requiring health providers and insurers to make health records available to patients in an easily accessible electronic format, a policy shift aimed at fueling broader efforts to use patient data to develop new software tools and services. [STAT News] Editorial Nearly two years ago, Charles River Laboratories paid $800 million for a company called MPI Research to bolster its business running clinical trials for drug makers and other companies. But Charles River did not know one MPI employee was an also undercover agent for the Humane Society of the United States and secretly filmed experiments conducted on various dogs, which were later publicized on the internet. [STAT News] Editorial
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EVENTSNEW 7th JCA-AACR Conference in Pancreatic Cancer Research Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Pancreatic Beta Cells (Washington University School of Medicine) Postdoctoral Fellowships – Pancreatic Disease (University of Copenhagen) Senior Scientist – Diabetes (International Institute of Innovation and Technology) Postdoctoral Fellow – Pancreatic Cancer (The University of Tennessee Health Science Center) Postdoctoral Associate – Pancreatic Cancer Biology Research (University of Miami Health System) Postdoctoral Fellow – Cancer Biology (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow – Diabetes (Harvard Joslin Diabetes Center) Postdoctoral Associate – RNA Cancer Biology and Diabetes (The Jackson Laboratory) Postdoctoral Fellowship – Diabetes and Kidney Diseases (National Institutes of Health) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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