Pancreatic Cell News Volume 11.09 | Mar 10 2020

TOP STORY

The MHC-II Peptidome of Pancreatic Islets Identifies Key Features of Autoimmune Peptides

The proinsulin-derived peptides followed a trajectory from their generation and exocytosis in β cells to uptake and presentation in islets and peripheral sites. [Nat Immunol] Abstract

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Pancreatic Islets Seeded in a Novel Bioscaffold Forms an Organoid to Rescue Insulin Production and Reverse Hyperglycemia in Models of Type 1 Diabetes

The implanted islet-seeded biomaterial assembled into a solid organoid substructure that reorganized the extracellular matrix compartment and recruited endothelial progenitors for neovascularization. [Sci Rep] Full Article

Microcystin-LR Impairs Glucose Metabolism in Pancreatic β Cells In Vivo and In Vitro

Direct cytotoxic effects of microcystin-LR (MC-LR) were observed in the MIN6 pancreatic β-cells possibly due to their expression of the MC-LR specific transporter. [Toxicol Lett] Abstract

Gangliosides Modulate Insulin Secretion by Pancreatic Beta-Cells under Glucose Stress

Isolated beta cells from GM3 synthase null mice were unable to synthesize GM3 and GD3, and showed lower glucose uptake than respective control cells, corroborating the results obtained from the cell-specific model. [Glycobiology] Abstract

Approved LXR Agonists Exert Unspecific Effects on Pancreatic β-Cell Function

Scientists evaluated whether effects of novel agonist drugs on β-cell function were specific and reliably linked to liver-X-receptor (LXR) activation. [Endocrine] Full Article

PANCREATIC CANCER

Cancer Associated Fibroblast FAK Regulates Malignant Cell Metabolism

Researchers demonstrated that FAK-depletion in cancer-associated fibroblasts increased chemokine production, which via CCR1/CCR2 on cancer cells, activated protein kinase A. [Nat Commun] Full Article

Laser-Assisted 3D Bioprinting of Exocrine Pancreas Spheroid Models for Cancer Initiation Study

Investigators generated 3D pancreatic cell spheroid arrays using laser-assisted bioprinting and characterized their phenotypic evolution over time through image analysis and phenotypic characterization. [Biofabrication] Abstract

Anti-Glypican-1 Antibody-Drug Conjugate Is a Potential Therapy against Pancreatic Cancer

The authors measured the antitumor effect of anti-glypican-1 monoclonal antibody conjugated with the cytotoxic agent monomethyl auristatin F in vitro and in vivo. [Br J Cancer] Abstract

Immuno-OpenPET: A Novel Approach for Early Diagnosis and Image-Guided Surgery for Small Resectable Pancreatic Cancer

Scientists report the feasibility of “immuno-OpenPET” as a novel approach enabling not only early diagnosis but also image-guided surgery, using a small resectable pancreatic cancer orthotopic xenograft mouse model. [Sci Rep] Full Article

Uncovering Differently Expressed Markers and Heterogeneity on Human Pancreatic Cancer

Researchers investigated the expression of seven markers related to the epithelial-to-mesenchymal transition on human pancreatic cancer tissue. [Transl Oncol] Full Article

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Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment

Recent advances in nanotechnology have emerged as promising alternative strategies for the management of diabetes. The authors provide a holistic summary of this rapidly advancing field compiling all aspects pertaining to the management of diabetes. [Trends Endocrinol Metab] Abstract

Dyslipidemia in Type 1 Diabetes: A Masked Danger

Although the mechanisms underlying type 1 diabetes dyslipidemia remain unclear, the subcutaneous route of insulin administration, that is responsible for peripheral hyperinsulinemia, is likely to be an important factor. [Trends Endocrinol Metab] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

The Pancreatic Cancer Collective Extends Four Research Teams in $16 Million Push for New Therapies

The Pancreatic Cancer Collective has awarded additional funding of up to $16 million to four teams of top researchers as part of its “New Therapies Challenge Grants,” the American Association for Cancer Research, Scientific Partner of SU2C. [The Pancreatic Cancer Collective] Press Release

Health Canada Approves Fast-Acting Mealtime Insulin, Fiasp^®, for Children with Diabetes

Fiasp^® is now approved in Canada for pediatric patients aged two years and above giving Canadian families managing type 1 or type 2 diabetes an effective treatment option to support optimal mealtime glucose control. [Novo Nordisk Canada, Inc. (Newswire, Inc.)] Press Release

FDA Proposes Broad Approach for Conducting Safety Trials for Type 2 Diabetes Medications

The FDA issued a new draft guidance, “Type 2 Diabetes Mellitus: Evaluating the Safety of New Drugs for Improving Glycemic Control,” to solicit public comment on its proposals for broad safety evaluations before drug approval. [FDA] Press Release

New Trump Rules Aim to Fuel Sharing of Patient Health Records by Smartphone

President Trump’s top health care aides said they will finalize federal rules requiring health providers and insurers to make health records available to patients in an easily accessible electronic format, a policy shift aimed at fueling broader efforts to use patient data to develop new software tools and services. [STAT News] Editorial

Clinical Research Company Sued over Stolen Trade Secrets after Employee Filmed Dogs Used in Experiments

Nearly two years ago, Charles River Laboratories paid $800 million for a company called MPI Research to bolster its business running clinical trials for drug makers and other companies. But Charles River did not know one MPI employee was an also undercover agent for the Humane Society of the United States and secretly filmed experiments conducted on various dogs, which were later publicized on the internet. [STAT News] Editorial

NEW 7^th JCA-AACR Conference in Pancreatic Cancer Research
June 9-11, 2020
Kyoto, Japan

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Fellow – Pancreatic Beta Cells (Washington University School of Medicine)

Postdoctoral Fellowships – Pancreatic Disease (University of Copenhagen)

Senior Scientist – Diabetes (International Institute of Innovation and Technology)

Investigator Group Leader – Metabolic Research in Diabetes (German Research Center for Environmental Health)

Postdoctoral Fellow – Pancreatic Cancer (The University of Tennessee Health Science Center)

Postdoctoral Fellow – Therapeutics in Pancreatic Cancer (The University of Tennessee Health Science Center)

Postdoctoral Associate – Pancreatic Cancer Biology Research (University of Miami Health System)

Postdoctoral Fellow – Cancer Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Diabetes (Harvard Joslin Diabetes Center)

Postdoctoral Associate – RNA Cancer Biology and Diabetes (The Jackson Laboratory)

Postdoctoral Fellowship – Diabetes and Kidney Diseases (National Institutes of Health)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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