Pancreatic Cell News 11.12 March 31, 2020 | |
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TOP STORYSenescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer Scientists showed that a combination of MEK and CDK4/6 inhibitors that target KRAS-directed oncogenic signaling suppressed pancreatic ductal adenocarcinoma proliferation through induction of retinoblastoma protein-mediated senescence. [Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISBeta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes Researchers report that modulating the unfolded protein response (UPR) in β cells of non-obese diabetic mice by deleting the UPR sensor IRE1α prior to insulitis induced a transient dedifferentiation of β cells, resulting in substantially reduced islet immune cell infiltration and β cell apoptosis. [Cell Metab] Abstract | Graphical Abstract Compared to the ubiquitous probe, exendin-4-dota(ga)-Gd(III) complex showed selective uptake by the pancreas with a marked decrease in accumulation observed after the loss of β-cells elicited by deleting the microRNA processing enzyme, DICER. [Dalton Trans] Abstract Deletion of Gpr27 In Vivo Reduces Insulin mRNA but Does Not Result in Diabetes Insulin and Pdx1 mRNA in Gpr27 knockout islets were reduced by 30%, but this did not translate to a reduction in islet insulin content or beta cell mass. [Sci Rep] Full Article PANCREATIC CANCERUsing circRNA sequencing, scientists identified 169 differentially expressed circRNA in pancreatic ductal adenocarcinoma cells compared to non-tumor human pancreatic ductal epithelial cells. [Cancer Res] Abstract Researchers used mass-spectrometry-based quantitative temporal proteomics to profile the proteomic response to KRAS inhibitors in pancreatic and lung cancer 2D and 3D cellular models. [Cell Rep] Full Article | Graphical Abstract Investigators showed that enhancement of the hexosamine biosynthetic pathway, through the upregulation of the enzyme phosphoacetylglucosamine mutase 3, was associated with the onset of gemcitabine resistance in pancreatic cancer. [Oncogene] Abstract Researchers studied the effect of mild hyperthermia on fibrillary collagen architecture in murine Achilles tendons and in a pancreatic cancer model, in vitro, i.e. 3D hetero-type tumor spheroids, consisting of pancreatic cancer cells and fibroblasts, producing collagen fibers. [Nanomedicine] Abstract | Graphical Abstract | Full Article In pancreatic ductal adenocarcinoma cell lines, Y-box binding protein 1 (YBX1) regulated cell cycle progression, proliferation, and the expression of glycogen synthase kinase 3 beta (GSK3B) and cell cycle-related proteins cyclin D1 and E1. [Mol Ther Oncolytics] Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSPancreatic Adenocarcinoma: Unconventional Approaches for an Unconventional Disease The authors review current treatments, limitations, and pitfalls in the management of pancreatic cancer and discusses current research in novel targets and drug development to overcome these clinical challenges. [Cancer Res] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSMyriad Genetics, Inc. announced it has submitted a supplementary application with the Japanese Ministry of Health Labour and Welfare for its BRACAnalysis® Diagnostic System to be used as a companion diagnostic to help to identify people with metastatic pancreatic or metastatic castration-resistant prostate cancer who have germline BRCA1 and BRCA2 mutations. [Myriad Genetics, Inc.] Press Release In response to the COVID-19 pandemic and its impact around the world, JDRF is working to ensure the 1.6 million Americans living with T1D stay informed and healthy during this challenging time. These efforts include continued advocacy to address the near- and long-term needs of the T1D community. [JDRF, Inc.] Press Release | |
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POLICY NEWSCull, Release or Bring Them Home: Coronavirus Crisis Forces Hard Decisions for Labs with Animals As universities scale back operations and scientists observe stay-at-home orders, many are struggling to protect their research and the animals that power it. [Nature News] Editorial Tens of Thousands of Scientists Are Redeploying to Fight Coronavirus As labs shut down around the world, researchers are finding creative ways to donate their time, supplies and expertise. [Nature News] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Inflammatory Cell Death (Genentech) Postdoctoral Research Position – Cancer Therapeutics (NIH National Cancer Institute) Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University) Postdoctoral Research Fellow – Pancreatic Beta Cells (Washington University School of Medicine) Senior Scientist – Diabetes (International Institute of Innovation and Technology) Postdoctoral Fellow – Pancreatic Cancer (The University of Tennessee Health Science Center) Postdoctoral Fellow – Cancer Biology (Memorial Sloan Kettering Cancer Center) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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