Pancreatic Cell News Volume 11.14 | Apr 14 2020

TOP STORY

Obesity-Induced Overexpression of miR-802 Impairs Insulin Transcription and Secretion

Repression of NeuroD1 in β cell and primary islets impaired insulin transcription and reduction of Fzd5 in β cell, which impaired Ca²⁺ signaling, thereby repressing calcium influx and decreasing insulin secretion. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

The T1D-Associated lncRNA Lnc13 Modulates Human Pancreatic β Cell Inflammation by Allele-Specific Stabilization of STAT1 mRNA

Up-regulation of Lnc13 in pancreatic β-cells increased activation of the proinflammatory STAT1 pathway, which correlated with increased production of chemokines in an allele-specific manner. [Proc Natl Acad Sci USA] Abstract

Loss-of-Function of the Long Non-Coding RNA A830019P07Rik in Mice Does Not Affect Insulin Expression and Secretion

Researchers investigated the impact of loss-of-function in mice of the lncRNA A830019P07Rik, hereafter P07Rik, which was previously reported to be associated with reduced plasma insulin levels. [Sci Rep] Full Article

Melatonin Modulates Red-Ox State and Decreases Viability of Rat Pancreatic Stellate Cells

Scientists showed that melatonin decreased pancreatic stellate cell viability in a concentration-dependent manner. Melatonin evoked a concentration-dependent increase in reactive oxygen species production in the mitochondria and in the cytosol. [Sci Rep] Full Article

CXXC4 Mediates Glucose-Induced β-Cell Proliferation

Decreased expression of CXXC4 correlated with high glucose treatment of INS-1 cells and primary rat β-cells. Adenovirus-mediated overexpression of CXXC4 inhibited cell proliferation induced by the high glucose treatment in vitro. [Acta Diabetol] Abstract

PANCREATIC CANCER

TGF-β1 Secreted by Pancreatic Stellate Cells Promotes Stemness and Tumorigenicity in Pancreatic Cancer Cells through L1CAM Downregulation

Cells with reduced expression of L1 cell adhesion molecule (L1CAM) harbored enhanced stemness potential and tumorigenicity. Inactivation of TGF-β1 signaling in pancreatic stellate cells strongly reduced the aggressiveness of pancreatic ductal adenocarcinoma cells. [Oncogene] Full Article

Exposure to Inorganic Arsenic and Its Methylated Metabolites Alters Metabolomics Profiles in INS-1 832/13 Insulinoma Cells and Isolated Pancreatic Islets

In INS-1 832/13 cells, all three arsenicals decreased succinate, a metabolite of Krebs cycle, which provided substrates for ATP synthesis in mitochondria. Acetylcarnitine was decreased consistently by exposures to arsenicals in both the cells and the islets. [Arch Toxicol] Abstract

Huaier Extract Restrains Pancreatic Cancer by Suppressing Wnt/β-Catenin Pathway

Researchers found that the proliferation, migration, invasion and epithelial-mesenchymal transition of pancreatic cancer cells were suppressed by treatment with Huaier extract and that apoptosis increased. [Biomed Pharmacother] Full Article

Loss of Heterozygosity for KrasG12D Promotes REDD1-Dependent, Non-Canonical Glutamine Metabolism in Pancreatic Ductal Adenocarcinoma

The authors showed that loss of heterozygosity for Kras^G12D led to a substantial increase in non-canonical glutamine metabolism in pancreatic ductal adenocarcinoma cells. [Biochem Biophys Res Commun] Full Article

PD-L1 Upregulation Accompanied with Epithelial-Mesenchymal Transition Attenuates Sensitivity to ATR Inhibition in p53 Mutant Pancreatic Cancer Cells

The effect of programmed death ligand 1 (PD-L1) on the sensitivity to VE-821 was investigated in p53 mutant pancreatic cancer cells. Researchers showed that BxPC-3 cells exhibited higher sensitivity to VE-821 than mesenchymal PANC-1 cells. [Med Oncol] Abstract

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Understanding Generation and Regeneration of Pancreatic β Cells from a Single-Cell Perspective

Scientists review recent advances in understanding β-cell generation and regeneration, in vivo and in vitro, from single-cell technologies, which could provide insights for optimization of diabetes therapy strategies. [Development] Abstract

Potential Role of Adenylyl Cyclase 8 Signaling Complexes in Regulating Insulin Secretion from Pancreatic Beta Cells

The authors explore the signaling complexes revolving around adenylyl cyclase isoform 8 in modulating insulin release, from the initial discovery of the importance of this adenylyl cyclase isoform to recent investigations of its interacting molecular partners. [Cell Signal] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

PharmaCyte Biotech Enters into License Agreement for COVID-19 Diagnostic Kits

PharmaCyte Biotech, Inc. announced that it entered into a License Agreement with Hai Kang Life Corporation Limited, a corporation organized under the laws of Hong Kong, pursuant to which Hai Kang granted to PharmaCyte a license to certain technology owned or controlled by Hai Kang related to COVID-19 diagnostic kits. [PharmaCyte Biotech, Inc.] Press Release

Fate Therapeutics Announces Worldwide Collaboration with Janssen for Novel iPSC-derived Cell-based Cancer Immunotherapies

Fate Therapeutics, Inc. announced a global collaboration and option agreement with Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson. [Fate Therapeutics, Inc.] Press Release

How Scientists Can Volunteer to Help Fight COVID-19

Around the world, bench scientists other than those actively studying the pandemic have largely been forced to scale back or even shut down their experiments out of COVID-19 precautions. But that doesn’t mean their skills and expertise can’t contribute to the worldwide effort to address the disease. [The Scientist] Editorial

After Claims of Sex Bias, Scientific Leader at NIH’s Child Health Institute Withdraws from New Job

Constantine Stratakis, the geneticist who directed intramural science at the National Institute of Child Health and Human Development for the past decade, withdrew from a position he was slated to take in June as executive director and chief scientific officer of the Research Institute of the McGill University Health Centre in Montreal, Canada. [ScienceInsider] Editorial

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NEW PhD Research Scientist – Beta Cells in Diet-Induced Diabetes (Medical University of Vienna)

Laboratory Manager – Diabetes (Helmholtz Zentrum München)

Postdoctoral Research Fellow – Inflammatory Cell Death (Genentech)

Postdoctoral Research Position – Cancer Therapeutics (NIH National Cancer Institute)

Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University)

Postdoctoral Research Fellow – Pancreatic Beta Cells (Washington University School of Medicine)

Senior Scientist – Diabetes (International Institute of Innovation and Technology)

Investigator Group Leader – Metabolic Research in Diabetes (German Research Center for Environmental Health)

Postdoctoral Fellow – Pancreatic Cancer (The University of Tennessee Health Science Center)

Postdoctoral Fellow – Therapeutics in Pancreatic Cancer (The University of Tennessee Health Science Center)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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