Pancreatic Cell News Volume 11.15 | Apr 21 2020

TOP STORY

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

Researchers identified aberrant beta cell expression of the peptide hormone cholecystokinin (Cck) in response to obesity and showed that islet Cck promoted oncogenic Kras-driven pancreatic ductal tumorigenesis. [Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

An analysis of function and gene expression networks identified a gene set associated with functional heterogeneity in β cells that could be used to predict electrophysiology. [Cell Metab] Abstract | Graphical Abstract

Paracrine Control of α-Cell Glucagon Exocytosis Is Compromised in Human Type-2 Diabetes

Investigators report that exocytosis was moderately reduced in α-cells of type-2 diabetes donors, without changes in voltage-dependent ion currents or granule trafficking. [Nat Commun] Full Article

Culture on a Native Bone Marrow-Derived Extracellular Matrix Restores the Pancreatic Islet Basement Membrane, Preserves Islet Function, and Attenuates Islet Immunogenicity

Compared to islets cultured on tissue culture plastic, islets cultured on 3D-extracellular matrix exhibited greater attachment, higher survival rate, increased insulin content, and enhanced glucose-stimulated insulin secretion. [FASEB J] Abstract

β-Cells Operate Collectively to Help Maintain Glucose Homeostasis

The authors suggest how the conservation of entire cell-cell conductance, observed in coupled but not uncoupled β-cells, emerged as a collective phenomenon. [Biophys J] Abstract

Dopamine D2 Receptor Activator Quinpirole Protects Against Trypsinogen Activation during Acute Pancreatitis via Upregulating HSP70

Pancreatic acinar cells were stimulated with cholecystokinin-8 in vitro. Acute pancreatitis was induced by intraperitoneal injections of caerulein and LPS or L-arginine. Pancreatitis severity was assessed biochemically and histologically. [Am J Physiol Gastrointest Liver Physiol] Abstract

PANCREATIC CANCER

MIF Inhibitor, ISO-1, Attenuates Human Pancreatic Cancer Cell Proliferation, Migration and Invasion In Vitro, and Suppresses Xenograft Tumor Growth In Vivo

The authors investigated the biological effects of specific MIF inhibitor, ISO-1, on the proliferation, migration and invasion of PANC-1 human pancreatic cells in vitro, and on tumor growth in a xenograft tumor model in vivo. [Sci Rep] Full Article

Neuroprotective Effect of Alogliptin on Oxaliplatin-Induced Peripheral Neuropathy In Vivo and In Vitro

Alogliptin did not attenuate tumor cytotoxicity of oxaliplatin in cultured colon, gastric, or pancreatic cancer cell lines and tumor-bearing mice. [Sci Rep] Full Article

PD-L1 Is a Direct Target of Cancer-FOXP3 in Pancreatic Ductal Adenocarcinoma (PDAC), and Combined Immunotherapy with Antibodies Against PD-L1 and CCL5 Is Effective in the Treatment of PDAC

Researchers confirmed that PD-L1 was overexpressed in pancreatic ductal adenocarcinoma (PDAC) samples from two independent cohorts of patients with radical resection. Cancer Forkhead box protein 3 (C-FOXP3) was colocalized and correlated with the expression of PD-L1 in tumor cells at the mRNA and protein levels. [Signal Transduct Target Ther] Full Article

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New Treatment Strategies for Metastatic Pancreatic Ductal Adenocarcinoma

Major efforts are underway to effectively target the tumor microenvironment and to integrate immunotherapy into the treatment of pancreatic ductal adenocarcinoma. [Drugs] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

First Patient Treated with Leronlimab in Phase IIb/III Trial for COVID-19

CytoDyn, Inc. announced it has treated the first patient in its Phase II basket trial for 22 solid cancer tumors. [CytoDyn, Inc.] Press Release

Chi-Med Announces Surufatinib Granted US FDA Fast Track Designations for the Treatment of Both Pancreatic and Non-Pancreatic Neuroendocrine Tumors

Hutchison China MediTech Limited announced that FDA has granted two Fast Track Designations for the development of surufatinib, for the treatment of both advanced and progressive pancreatic neuroendocrine tumors (NET) and extra-pancreatic NET in patients who are not amenable for surgery. [Chi-Med, Inc.] Press Release

Untapped Potential: More US Labs Could Be Providing Tests for Coronavirus

A survey of more than 4,000 researchers in the United States suggests that better coordination at an institutional and national level could make hundreds of thousands more tests for coronavirus available. [Nature News] Editorial

Director of US Agency Key to Vaccine Development Leaves Role Suddenly Amid Coronavirus Pandemic

Rick Bright, one of the nation’s leading vaccine development experts and the director of the Biomedical Advanced Research and Development Authority, is no longer leading the organization. [STAT News] Editorial

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NEW PhD Studentship – Cancer Biology Research (Danish Cancer Society Research Center)

PhD Research Scientist – Beta Cells in Diet-Induced Diabetes (Medical University of Vienna)

Laboratory Manager – Diabetes (Helmholtz Zentrum München)

Postdoctoral Research Fellow – Inflammatory Cell Death (Genentech)

Postdoctoral Research Position – Cancer Therapeutics (NIH National Cancer Institute)

Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University)

Postdoctoral Research Fellow – Pancreatic Beta Cells (Washington University School of Medicine)

Senior Scientist – Diabetes (International Institute of Innovation and Technology)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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