Pancreatic Cell News Volume 11.16 | Apr 28 2020

TOP STORY

Autophagy Promotes Immune Evasion of Pancreatic Cancer by Degrading MHC-I

Pancreatic ductal adenocarcinoma cells displayed reduced expression of MHC-I at the cell surface and instead demonstrated predominant localization within autophagosomes and lysosomes. [Nature] Full Article | Editorial

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Generation of Pancreatic β Cells from CD177⁺ Anterior Definitive Endoderm

CD177⁺ anterior definitive endoderm expressed and synthesized the secreted WNT, NODAL and BMP antagonist CERBERUS1 and was specified toward the pancreatic fate. [Nat Biotechnol] Abstract

Gene-Edited Human Stem Cell-Derived β Cells from a Patient with Monogenic Diabetes Reverse Preexisting Diabetes in Mice

After differentiation to β cells with a six-stage differentiation strategy, corrected Wolfram syndrome stem cell-β cells performed robust dynamic insulin secretion in vitro in response to glucose. [Sci Transl Med] Abstract

Novel Metabolic Role for BDNF in Pancreatic β-Cell Insulin Secretion

Scientists showed that the BDNF receptor TrkB.T1 was expressed by pancreatic β-cells where it regulated insulin release. [Nat Commun] Full Article

The YY1/miR-548t-5p/CXCL11 Signaling Axis Regulates Cell Proliferation and Metastasis in Human Pancreatic Cancer

The authors found that miR-548t-5p expression was significantly decreased in pancreatic cancer tissues compared with adjacent tissues. High miR-548t-5p expression inhibited the proliferation, migration, and invasion of pancreatic cancer cell lines. [Cell Death Dis] Full Article

PANCREATIC CANCER

Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer

Pancreatic ductal adenocarcinoma cells upregulated SLC38A2 to supply their increased alanine demand. Cells lacking SLC38A2 failed to concentrate intracellular alanine and underwent a profound metabolic crisis resulting in markedly impaired tumor growth. [Cancer Discov] Abstract

Novel Non-Integrating DNA Nano-S/MAR Vectors Restore Gene Function in Isogenic Patient-Derived Pancreatic Tumor Models

Nano-S/MAR modification did not alter the molecular or phenotypic integrity of patient-derived cells in cell culture and xenograft mouse models. [Mol Ther Methods Clin Dev] Abstract | Graphical Abstract

A Fluorescent Timer Reporter Enables Sorting of Insulin Secretory Granules by Age

The authors visualized insulin secretory granule aging behavior in MIN6 and INS1 beta-cell lines, and in primary C57BL/6J mouse and non-diabetic human islet cells. [J Biol Chem] Abstract | Download Full Article

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Integration of Nano- and Biotechnology for Beta-Cell and Islet Transplantation in Type-1 Diabetes Treatment

The authors develop and validate the application of single-photon emission computed tomography and optoacoustic imaging technologies in a transgenic insulin-deficient pig model to observe transplanted porcine xeno-islets and in vitro differentiated human beta cells. [Cell Prolif] Full Article

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

ERYTECH Provides Update on the TRYbeCA-1 Phase III Clinical Trial of Eryaspase in Second Line Pancreatic Cancer

ERYTECH Pharma provided an update on the pivotal Phase III clinical trial for advanced metastatic pancreatic cancer, which is evaluating the efficacy and safety of ERYTECH’s lead product candidate eryaspase in combination with chemotherapy as second-line therapy. [ERYTECH Pharma] Press Release

Chi-Med Announces Surufatinib Granted US FDA Fast Track Designations for the Treatment of Both Pancreatic and Non-Pancreatic Neuroendocrine Tumors

Hutchison China MediTech Limited announced that the US Food and Drug Administration has granted two Fast Track Designations for the development of surufatinib, for the treatment of both advanced and progressive pancreatic neuroendocrine tumors (NET) and extra-pancreatic NET in patients who are not amenable for surgery. [Hutchison China MediTech Limited] Press Release

Open Science Takes On the Coronavirus Pandemic

When reports emerged in late 2019 of an outbreak of a new coronavirus centred in Wuhan, China, researchers at the virological-analysis website Nextstrain were ready. The open-source project tracks the spread of viruses through genetic variations in the sequences that scientists find. [Nature News] Editorial

Director of US Agency Key to Vaccine Development Leaves Role Suddenly amid Coronavirus Pandemic

Rick Bright, one of the nation’s leading vaccine development experts and the director of the Biomedical Advanced Research and Development Authority, is no longer leading the organization. [STAT News] Editorial

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NEW PhD/MD/MCh Medical Traineeship – Pancreatic Cancer (University College Dublin)

PhD Studentship – Cancer Biology Research (Danish Cancer Society Research Center)

PhD Research Scientist – Beta Cells in Diet-Induced Diabetes (Medical University of Vienna)

Laboratory Manager – Diabetes (Helmholtz Zentrum München)

Postdoctoral Research Fellow – Inflammatory Cell Death (Genentech)

Postdoctoral Research Position – Cancer Therapeutics (NIH National Cancer Institute)

Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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