Pancreatic Cell News 11.22 June 9, 2020 | |
| |
TOP STORYAn Essential Role for Argonaute 2 in EGFR-KRAS Signaling in Pancreatic Cancer Development In mouse and human pancreatic tissues, pancreatic ductal adenocarcinoma progression was associated with increased plasma membrane localization of RAS/Argonaute 2. [Nat Commun] Full Article | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISβ-cell function was impaired by inhibiting autophagy in the longer-term, but conversely improved by three week deletion of Atg7, specifically under high-fat diet conditions. [Mol Metab] Full Article | Graphical Abstract Stat2 Loss Disrupts Damage Signaling and Is Protective in Acute Pancreatitis Stat2 deletion in pancreatic and duodenal homeobox 1-expressing acinar cells reduced pancreatic TNFα expression, but not histological injury or serum amylase [J Pathol] Abstract Expression of the Elk-1 mutant in pancreatic β-cells resulted in the generation of significantly smaller islets and increased caspase-3 activity, indicating that apoptosis was responsible for the reduction of the pancreatic islet size. [Pharmacol Res] Abstract | Graphical Abstract PANCREATIC CANCERScientists observed that gemcitabine treatment preferentially targeted G1 phase cells that had low surface phosphatidylserine (PS), resulting in an increased median surface PS level of pancreatic ductal adenocarcinoma cells. [Mol Ther] Abstract | Graphical Abstract Researchers describe the generation of highly metastatic pancreatic ductal adenocarcinoma patient-derived xenograft mouse models and subsequent single-cell RNA sequencing of circulating tumor cells, isolated by human HLA sorting. [Mol Cancer Ther] Abstract Compared to parental bulk FG cells, PAWI-2 showed greater potency to inhibit cell viability and self-renewal capacity of FGβ3 cells. [Sci Rep] Full Article R269C Variant of ESR1: High Prevalence and Differential Function in a Subset of Pancreatic Cancers R269C-estrogen receptor α (ESR1) enhanced E2-response elements (ERE) and AP1-dependent transcriptional activity and increased mRNA levels of ERE and AP1-regulated genes in pancreatic cancer cell lines. [BMC Cancer] Full Article LPS-induced inflammation in the presence of ATP activated NLRP3 that subsequently increased pancreatic cancer cell proliferation by increasing caspase-1 activity leading to overall production of IL-1β. [J Cancer Res Clin Oncol] Abstract LncRNA ZEB1-AS1 Promotes Pancreatic Cancer Progression by Regulating miR-505-3p/TRIB2 Axis CCK-8 assay was employed to analyze pancreatic cancer cell viability. Transwell assay was employed to detect the migration and invasion of pancreatic cancer cells. [Biochem Biophys Res Commun] Abstract Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
| |
REVIEWSThe pharmacological modulation of protein tyrosine phosphatase 1B (PTP1B) activity may help treat diabetic foot ulcers, suggesting that PTP1B inhibition was an outstanding therapeutic target. [Pharmacol Res] Abstract | Graphical Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
| |
INDUSTRY NEWSAstraZeneca and Merck announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion, recommending LYNPARZA for approval as monotherapy for the maintenance treatment of adult patients with germline BRCA1/2 mutations who have metastatic adenocarcinoma of the pancreas. [Merck] Press Release | |
| |
POLICY NEWSAs Pandemic Pounds US Universities, Federal Support Helps Their Labs Stay Afloat This spring, as the coronavirus pandemic shuttered US higher education, many college presidents began to warn of the dire financial impact of a frozen US economy on their institutions. Their mix of revenue sources largely determined how much they might be hurt. [ScienceInsider] Editorial As the Pandemic Hits Campus Finances, Faculty Face Layoffs The pandemic has bored holes in budgets at universities and colleges across the US and beyond. To stem the spread of the coronavirus, higher education institutions shuttered their campuses, sent students home, and moved classes online. [The Scientist] Editorial
| |
EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Senior Investigator – Electron Micrscopy Research (NIH National Cancer Institute) PhD Student – Pancreatic Cancer (University College Dublin) Postdoctoral Research Associate – Tumor Biology (University of Würzburg) Postdoctoral Associate – Pancreatic Disease Research (University of Miami Health System) Postdoctoral Fellow – Pancreas and Islet Biology Research (Vanderbilt University Medical Center) Postdoctoral Position – Diabetic Endothelial Cell Remodeling (Aarhus University) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Pancreatic Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|