 | Vol. 11.23 – June 16, 2020
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| Researchers found that heterozygous loss of histone H2A lysine 119 deubiquitinase BRCA1 Associated Protein-1 associated with a history of chronic pancreatitis and occurred in 25% of pancreatic ductal adenocarcinomas and 40% of acinar cell carcinomas.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To directly assess the role of NKG2D in the pancreas, researchers generated NOD mice that expressed an NKG2D ligand in β-islet cells.
[Diabetes] |
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| Scientists determined to what extent fasting glycemic indices could estimate stimulated β‐cell function in islet transplant recipients with and without basal insulin.
[American Journal of Transplantation] |
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| Investigators showed that the accelerated phenotype was driven by an early up-regulation of the pro-inflammatory cytokines TNFA and IL6 in normal acinar cells and accompanied by the recruitment of immune cells.
[Cell Death & Disease] |
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| Scientists used CRISPR–Cas9 technology to generate mice with mutations in the promoter regions of the insulin I and II genes.
[Communications Biology] |
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| In vivo activity of nanoliposomal irinotecan was validated in an orthotopic nude murine model expressing TAK1-specific shRNA. Differential expression profiling revealed the gene coding for interleukin-8 as the most significantly downregulated in shTAK1 pancreatic cancer cell lines.
[Clinical Cancer Research] |
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| Researchers showed glutathione S-transferase pi-1 knockdown reduced pancreatic ductal adenocarcinoma (PDAC) cell growth, prolonged the G0/G1 phase, and elevated reactive oxygen species in PDAC cells.
[Cancers] |
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| In multiple in vitro and in vivo models of pancreatic ductal adenocarcinoma (PDAC), spanning human and murine PDAC cells, and orthotopic xenografts, researchers determined that the expression of keratin 17 resulted in a more than two‐fold increase in resistance to Gem and 5‐fluorouracil, key components of current standard‐of‐care chemotherapeutic regimens.
[Molecular Oncology] |
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| Investigators showed that the accelerated phenotype is driven by an early up-regulation of the pro-inflammatory cytokines TNFA and IL6 in normal acinar cells and accompanied by the recruitment of immune cells.
[Scientific Reports] |
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| Researchers discuss the progression of type 2 diabetes mellitus in the context of beta-cell failure and describe how C-peptide testing can be used to assess beta-cell function in primary care practice.
[Postgraduate Medicine] |
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| Seven Bridges announced that it has been selected by the Pancreatic Cancer Action Network to build a customized, integrated health data platform to accelerate pancreatic cancer research.
[Seven Bridges Genomics] |
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| PharmaCyte Biotech, Inc. announced that cGMP Validation, the company’s cGMP consultant, has completed its post manufacturing audit of the manufacturing facility in Thailand and that the facility has successfully passed the audit.
[PharmaCyte Biotech, Inc.] |
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| China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News] |
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| 2020-10-12 – 2020-10-14
Paris, France | |
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| | Cornell University – New York City, New York, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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| | University College Dublin – Dublin, Ireland |
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| | Klinikum rechts der Isar der Technischen Universität München – Munich, Germany |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Vanderbilt University Medical Center – Nashville, Tennessee, United States |
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| | Aarhus University – Aarhus C, Denmark |
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| | The University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | Université de Montréal – Montréal, Quebec, Canada |
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