 | | Vol. 11.24 – 24 June, 2020 |
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| Overexpression of gap junction beta 4 protein (Gjb4) in primary islet cells significantly inhibited the proliferation by 47%, reduced insulin secretion of primary islets (46%) and INS-1 cells (51%) and enhanced the rate of apoptosis by 63% in INS-1 cells.
[Molecular Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists describe an ultrasensitive assay for detection of a β-cell-specific DNA methylation signature, by simultaneous assessment of six DNA methylation markers, that identified β-cell DNA in mixtures containing as little as 0.03% β-cell DNA (less than one β-cell genome equivalent).
[JCI Insight] |
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| Researchers demonstrated that GABA stimulated β‐cell proliferation via the PI3K/mTORC1/p70S6K pathway in both mouse and human islets.
[Diabetes Obesity & Metabolism] |
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| Investigators examined the effects of luzindole, a melatonin receptor‐antagonist, on cultured pancreatic stellate cells. Stimulation of cells with luzindole evoked a slow and progressive increase in intracellular free Ca2+ towards a plateau.
[Journal of Applied Toxicology] |
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| By comparing early mouse pancreatic lesions, non-invasive regions showed apoptosis-associated tyrosine kinase (AATK) co-expression in cells with acinar-to-ductal metaplasia, nuclear VAV1 localization, and cell cycle suppression.
[Clinical Epigenetics] |
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| Investigators found that the expression of homeobox protein VentX, a master regulator of macrophage plasticity, was significantly decreased in the pancreatic ductal adenocarcinoma (PDA)-tumor associated macrophages (TAMs). They demonstrated that VentX was required for phagocytosis and that restoration of VentX expression in PDA-TAMs promoted phagocytosis through regulating the signaling cascades involved in the process.
[JCI Insight] |
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| The expression of IL-5R and the effects of IL-5 were analyzed in human and murine tumor cells. IL-5 stimulated tumor cell migration and activation through STAT5 signaling, thereby suggesting an unreported tumor-promoting role for IL-5Rα in pancreatic cancer.
[Cell Communication and Signaling] |
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| In the field of pancreatic cancer, the MiaPaCa-2 cell line is an interesting model for research but it is known for its difficulty to form stable spheroids; also, when formed, spheroids from this cell line are weak and arduous to manage and to harvest for further analyses such as multiple staining and imaging.The authors compared different methods to evaluate which one allowed to better overpass these limitations.
[Scientific Reports] |
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| Scientists analyzed the basal CpG methylation of 11 KRAS-mutant and dependent pancreatic cancer cell lines and observed strikingly similar methylation patterns. KRAS knockdown resulted in unique methylation changes with limited overlap between each cell line.
[Scientific Reports] |
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| Investigators evaluated the mechanical invasiveness of established breast and pancreatic cell lines and of tumor-cells from fresh, suspected pancreatic cancer tumors. The mechanical invasiveness matched the in vitro metastatic potential in cell lines as determined with Boyden chamber assays.
[Annals of Biomedical Engineering] |
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| The authors review the molecular mechanism of insulin receptor endocytosis and its impact on the pathophysiology of insulin resistance, and discuss the potential of Src homology phosphatase 2 as a therapeutic target for type 2 diabetes.
[Experimental and Molecular Medicine] |
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| Corbus Pharmaceuticals Holdings, Inc. announced that the last subject completed their final visit in the company’s Phase IIb JBT101-CF-002 trial of lenabasum for the treatment of cystic fibrosis.
[Corbus Pharmaceuticals Holdings, Inc] |
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| With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News] |
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| 2020-07-16 – 2020-07-17
Virtual |
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| | Cold Spring Harbor Laboratory – Long Island, New York, United States |
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| | Cornell University – New York City, New York, United States |
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| | University of California – San Francisco, California, United States |
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| | Klinikum rechts der Isar der Technischen Universität München – Munich, Germany |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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