Pancreatic Cell News Volume 11.25 | Jun 30 2020

    By
    Justin.choi
    -
    0
    37







    2020-06-30 | PACN 11.25


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 11.25 – 30 June, 2020
    TOP STORY

    Long-Term Culture of Human Pancreatic Slices as a Model to Study Real-Time Islet Regeneration

    Using a culture system designed to mimic the physiological oxygenation of the pancreas, researchers demonstrated high viability and preserved endocrine and exocrine function in human pancreatic slices for at least ten days after sectioning.
    [Nature Communications]

    Full Article

    Virtual Conference Exhibition: Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    Localized Immunosuppression with Tannic Acid Encapsulation Delays Islet Allograft and Autoimmune-Mediated Rejection

    Transplantation of poly(N-vinylpyrrolidone)/tannic acid (PVPON/TA)-encapsulated islets was immunomodulatory as gene expression and flow cytometric analysis revealed significantly decreased in immune cell infiltration, synthesis of ROS, inflammatory chemokines, cytokines, CD8 T cell effector responses, and concomitant increases in alternatively-activated M2 macrophage and dendritic cell phenotypes.
    [Diabetes]

    Abstract

    AAV8 Ins1-Cre can Produce Efficient β-Cell Recombination but Requires Consideration of Off-Target Effects

    Intraperitoneal AAV8 Ins1-Cre produced efficient β-cell recombination, alongside some hepatic, exocrine pancreas, α-cell, δ-cell, and hypothalamic recombination. Delivery of lower doses via the pancreatic duct retained good rates of β-cell recombination and limited rates of off-target recombination.
    [Scientific Reports]

    Full Article

    Genome-Wide Association Meta-Analysis Identifies GP2 Gene Risk Variants for Pancreatic Cancer

    Researchers identified three genome-wide significant loci, of which 16p12.3 have not been reported in the Western population. Functional analyses using cell lines provided supporting evidence of the effect of rs78193826 on KRAS activity.
    [Nature Communications]

    Full Article

    Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors

    By manipulating Rb and p53 genes, scientists established a multistep progression model from dysplastic islets to indolent pancreatic neuroendocrine tumors (PanNET) and aggressive metastatic PanNET in mice.
    [Cancer Research]

    Abstract

    CD200 Promotes Immunosuppression in the Pancreatic Tumor Microenvironment

    Myeloid-derived suppressor cells isolated from patients with pancreatic ductal adenocarcinoma expressed elevated levels of the CD200 receptor.
    [Journal For ImmunoTherapy of Cancer]

    Full Article

    WD Repeat-Containing Protein 1 Maintains β-Catenin Activity to Promote Pancreatic Cancer Aggressiveness

    Scientists identified several previous functional unknown proteins implicated in the progression of pancreatic ductal adenocarcinoma (PDAC), and provided new insight into the oncogenic roles of WD repeat-containing protein 1 in PDAC development.
    [British Journal of Cancer]

    Abstract

    High Expression of AMAP1, An ARF6 Effector, Is Associated with Elevated Levels of PD-L1 and Fibrosis of Pancreatic Cancer

    With an aim to understand whether the ARF6-AMAP1 pathway was critically involved in the elevated levels of PD-L1 and fibrosis of pancreatic ductal carcinoma, investigators analyzed the relationship between AMAP1 and these malignant phenotypes.
    [Cell Communication and Signaling]

    Full Article

    Additive Clinical Impact of Epidermal Growth Factor Receptor and Podocalyxin-Like Protein Expression in Pancreatic and Periampullary Adenocarcinomas

    The effect of transforming growth factor β-induced expression and siRNA-mediated knockdown of podocalyxin-like protein and epidermal growth factor receptor, were investigated in pancreatic cancer cells in vitro.
    [Scientific Reports]

    Full Article

    Pathogen infection studies lacked an optimal culture system. Then she used organoids.
    REVIEWS

    Emerging Routes to the Generation of Functional β-Cells for Diabetes Mellitus Cell Therapy

    Substantial advances have been made in producing mature β-cells from human pluripotent stem cells that respond appropriately to dynamic changes in glucose concentrations in vitro and rapidly function in vivo following transplantation in mice.
    [Nature Reviews Endocrinology]

    Abstract

    Functional Loss of Pancreatic Islets in Type 2 Diabetes: How Can We Halt It?

    The authors provide a view of the experimental and clinical evidence on the ability of available anti-diabetes drugs to exert protective effects on beta-cells, with a specific focus on human pancreatic islets and clinical trials.
    [Metabolism-Clinical and Experimental]

    Abstract

    INDUSTRY AND POLICY NEWS

    Corcept Therapeutics Initiates Phase III Trial of Relacorilant Plus Nab-Paclitaxel in Patients with Metastatic Pancreatic Cancer

    Corcept Therapeutics Incorporated announced enrollment of the first patient in RELIANT, an open-label, Phase III trial of relacorilant in combination with nab-paclitaxel in patients with metastatic pancreatic cancer.
    [Corcept Therapeutics Incorporated]

    Press Release

    IM Therapeutics Announces First Patient Dosed in Phase I Study of its Lead Drug IMT-002 for Type 1 Diabetes

    ImmunoMolecular Therapeutics announced the dosing of the first patient in a Phase I study of IMT-002, an oral small molecule drug designed as a selective HLA-DQ8 blocker for the treatment of type 1 diabetes.
    [IM Therapeutics]

    Press Release

    Mounting Clues Suggest the Coronavirus Might Trigger Diabetes

    Evidence from tissue studies and some people with COVID-19 shows that the virus damages insulin-producing cells.
    [Nature News]

    Editorial

    NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

    On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
    [Nature News]

    Editorial

    FEATURED EVENT

    Micro-CT: Fancy Gadget or Indispensable Technology towards Accurate Quantification of Lung Disease and Therapy?

    July 9
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Positions – Cancer Genomics/Computational Biology

    Stanford Institute for Stem Cell Biology and Regenerative Medicine ( – Stanford, California, United States

    Lab Manager – Pancreatic Ductal Adenocarcinoma

    Cold Spring Harbor Laboratory – Long Island, New York, United States

    Postdoctoral Fellow in Diabetes, Molecular Metabolism and Cardiovascular Research

    Cornell University – New York City, New York, United States

    Postdoctoral Scholar – Developmental & Stem Cell Biology

    University of California – San Francisco, California, United States

    Postdoctoral Scientist Position – Drug Vulnerabilities of Pancreatic Cancer

    Klinikum rechts der Isar der Technischen Universität München – Munich, Germany

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Pancreatic Cell News Twitter