 | | Vol. 11.26 – 14 July, 2020 |
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| The authors’ microarray analysis of pancreatic tissues from mild and severe acute pancreatitis mice models identified angiopoietin‐like 4 (ANGPTL 4) as one of the most significantly upregulated genes.
[EMBO Molecular Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | | Investigators describe an in vitro platform that modeled features of human type 1 diabetes using stress-induced patient-derived endocrine cells and autologous immune cells.
[Cell Reports] |
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| Scientists showed that low expression of κB-Ras GTPases was frequently detected in pancreatic ductal adenocarcinoma and correlated with higher histologic grade.
[Nature Communications] |
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| Pancreatic cancer cells exhibited increased pyruvate carboxylation relative to fibroblasts, and this flux depended on both pyruvate carboxylase and malic enzyme 1 activity.
[eLife] |
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| Scientists validated tumor CALB2 and stromal COL11A1 expression as compartment-specific prognostic markers. They identified and functionally addressed the contributions of the tumor cell receptor EPHA2 to tumor cell viability and motility, underscoring the value of compartment-specific protein analysis in pancreatic ductal adenocarcinoma.
[JCI Insight] |
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| Investigators found that the expression of CD73 was up‐regulated in pancreatic cancer tissues and patients with higher CD73 expression had poorer overall survival and disease‐free survival in multiple publicly available databases.
[Journal of Cellular and Molecular Medicine] |
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| Pancreatic tumor cell lines were stimulated with the chemotherapeutic agents and markers of immune recognition were assessed.
[Clinical and Translational Oncology] |
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| The authors review recent advances in the engineering of stem cell-derived β (SC-β) cells to understand and improve SC-β cell differentiation and functional maturation, particularly new differentiation strategies achieving dynamic glucose-responsive insulin secretion with rapid correction to normoglycemia when transplanted into diabetic mice.
[Frontiers in Bioengineering and Biotechnology] |
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| Investigators review the biological sources and functions of exosomes, as well as intercellular crosstalk between β-cells and other cells that is involved in β-cell failure and regeneration.
[Archives of Physiology and Biochemistry] |
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| US President Donald Trump’s government has dropped its plans to deport international students whose courses move fully online because of the coronavirus pandemic.
[BBC] |
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| To address the problem of poor reporting, Percie du Sert and a team of researchers have developed a checklist of 10 critical details each animal study needs to report, such as the number of animals used, their sex, whether they were randomly allocated to a test group and control group, and whether the researchers knew which animal was in which group.
[Science Insider] |
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| Galera Therapeutics, Inc. announced that it has completed patient enrollment in its pilot Phase Ib/IIa safety and anti-cancer efficacy clinical trial of avasopasem manganese in combination with stereotactic body radiation therapy in patients with locally advanced pancreatic cancer.
[Galera Therapeutics, Inc.] |
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| AstraZeneca and MSD Inc. announced that Lynparza has been approved in the European Union (EU) for patients with germline BRCA-mutated metastatic pancreatic cancer.
[AstraZeneca PLC] |
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| August 17 – August 19
Virtual |
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| | Lund University – Lund, Sweden |
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| | Stanford Institute for Stem Cell Biology and Regenerative Medicine ( – Stanford, California, United States |
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| | Cold Spring Harbor Laboratory – Long Island, New York, United States |
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| | Cornell University – New York City, New York, United States |
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| | University of California – San Francisco, California, United States |
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