 | | Vol. 11.31 – 18 August, 2020 |
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| Investigators previously found that metastatic pancreatic cancers were dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD). Here, they report a metabolic adaptation that stably activated PGD to reprogram metastatic chromatin.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | | By leveraging a multiple-site conjugation platform, researchers successfully engineered INS-1E, a β-cell line, to repurpose the insulin secretion machinery, which enabled the glucose-dependent secretion of protective immunomodulatory factor interleukin-10.
[Nature Communications] |
| | Scientists investigated the direct effect of Teneligliptin, a newer DPP-4 inhibitor on beta-cell function and survival in response to high glucose conditions. Teneligliptin treatment enhanced SIRT1 stability and activity by USP22, a ubiquitin specific peptidase.
[Free Radical Biology and Medicine] |
| | The authors investigated the role of the STING-IRF3 signaling pathway in lipotoxicity-induced inflammation, apoptosis, and dysfunction of pancreatic β cells.
[Molecular and Cellular Endocrinology] |
| | Researchers investigated the role of lncRNA plasmacytoma variant translocation 1 (PVT1) in rat insulinoma cells damaged by streptozotocin, to identify the potential mechanisms.
[Canadian Journal of Physiology and Pharmacology] |
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| Expression of integrin αvβ3 was examined in patient tissue and cultured cells. Effects of protein ProAgio on cancer-associated pancreatic stellate cells were analyzed by using an apoptosis assay kit. Effects of ProAgio in pancreatic ductal adenocarcinoma tumor were studied in three murine tumor models.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Researchers found that Linc01232 was significantly upregulated in pancreatic cancer tissues and cells and higher Linc01232 expression was associated with poorer prognosis.
[Cancer Letters] |
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| Investigators report the effect of K73-03, a new novel oleanolic acid derivative, against pancreatic cancer through mitochondrial dysfunction via miR-421/SPINK1 regulation.
[Pharmacological Research] |
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| Scientists described most of the lncRNAs with aberrant expression patterns in pancreatic cancer as detected by microarray. They indicated that LINC00671 acted as a novel tumor suppressor in pancreatic cancer.
[Cancer Gene Therapy] |
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| Oncolytic viruses are the ideal candidates for counteracting the pancreatic immunosuppressive tumor microenvironment and for designing combination therapies that can be clinically exploited in clinical trials that seek to improve the prognosis of pancreatic ductal adenocarcinoma .
[Cytokine & Growth Factor Reviews] |
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| The authors comprehensively summarize the emerging upstream regulators, downstream substrates, mouse models, clinical relevance, and candidate inhibitors for SIKs, and shed light on SIKs as the potential therapeutic targets for cancer therapies.
[Signal Transduction and Targeted Therapy] |
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| Provectus has announced expansion of their sponsored research program with the Cumming School of Medicine of the University of Calgary. The Calgary team will investigate oral dosing of cGMP rose bengal disodium in in vivo murine models for the treatment of refractory adult solid tumors that are high-risk phenotypes and have high metastatic potential. These cancer types will include head and neck, breast, pancreatic, liver, and colorectal.
[Provectus Biopharmaceuticals, Inc. (GlobeNewswire, Inc.)] |
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| Fractyl Laboratories Inc. has announced a first close of $55 million in a Series E financing. The proceeds from the financing will be used to support the Revita T2Di pivotal clinical trial of Revita duodenal mucosal resurfacing (DMR) for the treatment of patients with type 2 diabetes.
[Fractyl Laboratories, Inc.] |
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| Sep 7 – 11, 2022
Woods Hole, Massachusetts, United States |
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| | Princess Margaret Cancer Center – Toronto, Ontario, Canada |
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| | John Hopkins Medical Institute – Baltimore, Maryland, United States |
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| | City of Hope – Monrovia, California, United States |
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| | New York University School of Medicine – New York City, New York, United States |
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| | Cold Spring Harbor Laboratory – New York City, New York, United States |
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