Pancreatic Cell News Volume 11.32 | Aug 25 2020

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    Justin.choi
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    2020-08-25 | PACN 11.32


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 11.32 – 25 August, 2020
    TOP STORY

    Immune-Evasive Human Islet-Like Organoids Ameliorate Diabetes

    Scientists generated human islet-like organoids from induced pluripotent stem cells and showed that non-canonical WNT4 signaling drove the metabolic maturation necessary for robust ex vivo glucose-stimulated insulin secretion.
    [Nature]

    Abstract


    On-demand Webinar on Studying Cystic Fibrosis using Primary Human Nasal Epithelial Cells - Watch Now
    PUBLICATIONSRanked by the impact factor of the journal

    Zonation of Pancreatic Acinar Cells in Diabetic Mice

    The authors combined single-molecule transcript imaging in the intact pancreas and transcriptomics to identify spatial heterogeneity of acinar cell gene expression. They found that peri-islet acinar cells exhibited a distinct molecular signature in db/db diabetic mice that included upregulation of trypsin family genes and elevated mTOR activity.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Chebulic Acid Prevents Methylglyoxal-Induced Mitochondrial Dysfunction in INS-1 Pancreatic β-Cells

    Researchers indicated that chebulic acid could be employed as a therapeutic agent in diabetes due to its ability to prevent methyl glyoxal-induced development of insulin sensitivity and oxidative stress-induced dysfunction of β-cells.
    [Antioxidants]

    Full Article

    Epigenetic Silencing of the Ubiquitin Ligase Subunit FBXL7 Impairs C-Src Degradation and Promotes Epithelial-to-Mesenchymal Transition and Metastasis

    Investigators implicated FBXL7 as a metastasis-suppressor gene and suggested therapeutic strategies to counteract metastatic dissemination of pancreatic and prostatic cancer cells.
    [Nature Cell Biology]

    Abstract

    Use of Ratiometrically Designed Nanocarrier Targeting CDK4/6 and Autophagy Pathways for Effective Pancreatic Cancer Treatment

    Utilizing remote loading to co-encapsulate CDK4/6 inhibitor palbociclib and an autophagy inhibitor hydroxychloroquine, scientists demonstrated a ratiometrically designed mesoporous silica nanoformulation with synergistic efficacy in subcutaneous and orthotopic pancreatic ductal adenocarcinoma mouse models.
    [Nature Communications]

    Full Article

    The Roles of MAGEA6 Variants in Pancreatic Cancer Development and Their Potential Impact on Cancer Immunotherapy

    Researchers provided mechanistic insight into the divergent roles of MAGEA6 during pancreatic cancer initiation and progression, and could inform cancer immunotherapeutic strategies for targeting MAGEA antigens.
    [Autophagy]

    Abstract

    Mint3 Depletion Restricts Tumor Malignancy of Pancreatic Cancer Cells by Decreasing SKP2 Expression via HIF-1

    Investigators found that HIF-1 was accumulated in normoxic or moderate hypoxic areas of pancreatic cancer xenografts in vivo and is active even during normoxia in pancreatic cancer cells in vitro.
    [Oncogene]

    Full Article

    Synergistic Effects of Pulsed Focused Ultrasound and a Doxorubicin-Loaded Microparticle–Microbubble Complex in a Pancreatic Cancer Xenograft Mouse Model

    The synergistic effects of a doxorubicin-loaded microparticle–microbubble complex and focused ultrasound with a short duty cycle were evaluated in a pancreatic cancer xenograft model established by inoculating immunodeficient mice with CFPAC-1 cells.
    [Ultrasound in Medicine and Biology]

    Abstract

    Hyperthermal Paclitaxel-Bound Albumin Nanoparticles Co-Loaded with Indocyanine Green and Hyaluronidase for Treating Pancreatic Cancers

    Scientists fabricated albumin nanoparticles loaded with paclitaxel, indocyanine green and hyaluronidase that breaks down hyaluronan, a major component of the extracellulr matrix in tumors.
    [Archives of Pharmacal Research]

    Abstract

    Pathogen infection studies lacked an optimal culture system. Then she used organoids.
    REVIEWS

    Roles of CA19-9 in Pancreatic Cancer: Biomarker, Predictor and Promoter

    Carbohydrate antigen 19-9 (CA19-9) is an attractive therapeutic target for pancreatic cancer, and strategies include therapeutic antibodies and vaccines, CA19-9-guided nanoparticles, and inhibition of CA19-9 biosynthesis.
    [Biochimica Et Biophysica Acta-Reviews On Cancer]

    Abstract

    INDUSTRY AND POLICY NEWS

    Zosano Pharma Announces Agreement to Collaborate with Mitsubishi Tanabe Pharma Corporation

    Zosano Pharma Corporation announced that it has entered into a feasibility study agreement with Mitsubishi Tanabe Pharma Corporation centered on its priority disease areas — autoimmune diseases, diabetes and kidney diseases, central nervous system diseases, and vaccines.
    [Zosano Pharma Corporation]

    Press Release

    AzurRx BioPharma Announces Positive Interim Data from First Patient Cohort in Phase II Clinical Trial of MS1819 in Combination with PERT Therapy in the Treatment of Cystic Fibrosis Patients with Severe Exocrine Pancreatic Insufficiency

    AzurRx BioPharma, Inc. has announced positive results from the first five patients in its Phase II combination therapy trial of MS1819 for the treatment of severe exocrine pancreatic insufficiency in patients with cystic fibrosis. Patients receiving MS1819 in combination with PERT therapy achieved a clinically meaningful improvement in the coefficient of fat absorption at each of the three dose levels, with no adverse safety events reported.
    [AzurRx BioPharma, Inc.]

    Press Release

    FEATURED EVENT

    Cancer Stem Cells: Advances in Biology and Clinical Translation

    May 18 – 21, 2021
    Hannover, Germany

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Immune Oncology

    Princess Margaret Cancer Center – Toronto, Ontario, Canada

    Research Postdoctoral Fellow – Non-Alcoholic Fatty Liver Diseases & T2D

    John Hopkins Medical Institute – Baltimore, Maryland, United States

    Postdoctoral Positions – Cancer Genomics/Computational Biology

    Stanford Institute for Stem Cell Biology and Regenerative Medicine – Stanford, California, United States

    Staff Scientist – Molecular Diagnostics & Experimental Therapeutics

    City of Hope – Monrovia, California, United States

    Postdoctoral Fellow – Pancreatic and Liver Malignancies

    Weill Cornell Medicine – New York, New York, United States

    > See All Jobs

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