 | | Vol. 11.34 – 8 September, 2020 |
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| Investigators developed an in vitro disease-in-a-dish model using iPSCs from type 2 diabetes (T2D) patients differentiated into myoblasts (iMyos). They found that T2D iMyos in culture exhibited multiple defects mirroring human disease, including an altered insulin signaling, decreased insulin-stimulated glucose uptake, and reduced mitochondrial oxidation.
[Cell Metabolism] |
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| | PUBLICATIONSRanked by the impact factor of the journal |
| | | The authors report the successful subcutaneous transplantation of pancreatic islets admixed with a device-free islet viability matrix, resulting in long-term euglycemia in diverse immune-competent and immuno-incompetent animal models.
[Nature Metabolism] |
| | Scientists identified extracellular matrix structures as previously unrecognized participants in the mechanism underlying diabetes remission induced by the central action of fibroblast growth factor 1.
[Nature Communications] |
| | Investigators implemented a synthetic biomaterial platform for the local delivery of a chimeric streptavidin/programmed cell death-1 (SA-PD-L1) protein to direct “reprogramming” of local immune responses to transplanted pancreatic islets.
[Science Advances] |
| | Researchers used the polyclonal human pancreatic neuroendocrine tumor cell line BON1, which expresses menin, serotonin, chromogranin A and neurotensin, to generate a monoclonal stable MEN1 knockout BON1 cell line by CRISPR/Cas9 editing.
[Scientific Reports] |
| | Scientists sought to determine a mechanism by which L-arginine increased glucose-stimulated insulin secretion in β-cells by finding a protein with affinity to L-arginine using arginine-immobilized magnetic nanobeads technology.
[Communications Biology] |
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| Researchers provided evidence of essential roles of myeloma overexpressed (MYEOV) in the development and progression of pancreatic ductal adenocarcinoma. In tumor specimens derived from pancreatic cancer patients, MYEOV was overexpressed and associated with poor prognosis.
[Oncogene] |
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| The authors generated total RET and isoform-specific knockdown pancreatic ductal adenocarcinoma (PDAC) cell lines and assessed the contributions of RET isoforms to PDAC invasive spread. They showed that RET activity induced cell polarization and actin remodeling through activation of CDC42 and RHOA GTPases to promote directional motility in PDAC cells.
[Oncogene] |
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| Investigators performed a large-scale circRNA profiling analysis in human pancreatic ductal adenocarcinoma (PDAC) tissues, using circular RNA-specific RNA sequencing. They identified more than 40,000 previously unknown circRNAs, some of which were upregulated in PDAC tissues, compared with normal pancreatic tissues.
[Journal of Human Genetics] |
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| The authors highlight the importance of epitranscriptomic and epiproteomic modification in cancer drug resistance and provides new insights on potential therapeutic targets to reverse cancer drug resistance.
[Signal Transduction and Targeted Therapy] |
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| The FDA has approved the latest automated artificial pancreas system from Medtronic, the MiniMed 770G, for adults and children with Type 1 diabetes as young as two years old.
[Fierce Biotech] |
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| | City of Hope – Duarte, California, United States |
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| | The University of Melbourne – Melbourne, Victoria, Australia |
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| | Helmholtz Center Munich – Neuherberg/München, Germany |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | NYU Langone Health – New York, New York, United States |
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