| Vol. 11.36 – 22 September, 2020 |
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| Researchers demonstrated that expression of the transcriptional coregulator GPS2 in white adipose tissue was correlated with insulin secretion rate in humans. [Cell Reports] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | | The authors leveraged the strengths of the zebrafish—genetic manipulation and pharmacologic inhibition—to interrogate the role of 12‐lipoxygenase (12‐LOX) in pancreatic development. Lipidomics analysis during zebrafish development demonstrated that 12‐LOX‐generated metabolites of arachidonic acid increased sharply during organogenesis stages, and that this increase was blocked by morpholino‐directed depletion of 12‐LOX. [FASEB Journal] |
| | Scientists present a study of β-cell metabolism under increased fuel pressure using a stable isotope resolved NMR approach to investigate early metabolic events leading up to β-cell dysfunction. [Scientific Reports] |
| | Investigators observed a cooperation between different AKT isoforms and FAK-dependent adhesion signaling, which controlled either glucose-stimulated insulin secretion or prevented insulin secretion under fasting conditions. [Journal of Biological Chemistry] |
| | Researchers demonstrated that hypoxia-inducible factor-1-mediated transcriptional activation of NOX4 and the ensuing increase in H2O2 contributed to intermittent hypoxia-induced pancreatic β-cell dysfunction. [American Journal of Physiology-Cell Physiology] |
| | Cholesterol reduced pancreatic β-cell viability in a dose and time-dependent manner, with an improvement in the presence of the metabolites. Flavanone metabolites attenuated oxidative stress by reducing levels of lipid peroxides, superoxide anions, and hydrogen peroxide. [Food & Function] |
| | Myricetin supplementation inhibited human islet amyloid polypeptide aggregation and disaggregated preformed fibrils into non-toxic species. This protection was accompanied by inhibition of oxidative stress, reduction in lipid peroxidation and the associated membrane damage and restoration of mitochondrial membrane potential in INS-1E cells. [Biological Chemistry] |
| | Coculturing CD19-expressing β-like cells and CD19 CAR-T cells resulted in T cell-mediated β-like cell death with release of activated T cell cytokines. [Cell Reports Medicine] |
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| Scientists used a Drosophila model of high-sugar diet-enhanced tumorigenesis to uncover a systemic host-tumor metabolic circuit that supported tumor growth. [Nature Communications] |
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| Functional experiments demonstrated that tumor suppressor long noncoding RNA on chromosome 8p12 (TSLNC8) promoted pancreatic cancer (PC) cells’ proliferation and invasion in vitro, and enhanced PC growth and metastasis in vivo. [Human Cell] |
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| The authors provide an overview of the recent advances on the mechanistic aspects of the PD-1 pathway and discuss the implications of these new discoveries and the gaps that remain to be filled. [Science Advances] |
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| Scientists review the existing preclinical data regarding the role of autophagy in pancreatic ductal adenocarcinoma, as well as results of relevant clinical trials with agents that modulate autophagy in this cancer. [British Journal of Cancer] |
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| Galera Therapeutics, Inc. announced that it will host a virtual key opinion leader (KOL) event on locally advanced pancreatic cancer on Friday, October 2, 2020, at 11 a.m. EDT. [Galera Therapeutics, Inc.] |
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| May 18 – May 21, 2021 Hannover, Germany |
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| University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| City of Hope – Monrovia, California, United States |
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| Washington University in St. Louis – St. Louis, Missouri, United States |
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| City of Hope – Duarte, California, United States |
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| The University of Melbourne – Melbourne, Victoria, Australia |
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