 | | Vol. 11.37 – 29 September, 2020 |
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| The authors defined a mechanism by which cholesterol metabolism controls the development and differentiation of pancreatic ductal adenocarcinoma.
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A nucleoside reverse-transcriptase inhibitor (NRTI), lamivudine, improved insulin sensitivity and reduced inflammasome activation in diabetic and insulin resistance-induced human cells, as well as in mice fed with high-fat chow.
[Nature Communications] |
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| Investigators explored the novel hypothesis that regulation of growth factor receptor trafficking can be used to promote islet beta cell survival. Growth factor signaling was dependent on the presence of cell surface receptors.
[Scientific Reports] |
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| Scientists demonstrated that TSPAN1 was upregulated in pancreatic cancer and that TSPAN1 depletion decreased pancreatic cancer cell proliferation in vitro and in vivo. TSPAN1 expression was correlated with poor overall survival of pancreatic cancer patients.
[Autophagy] |
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| Researchers interrogated purified sorted tumor fractions from a series of 15 tumor samples with whole-genome copy-number variant, whole-exome sequencing, and assay for transposase-accessible chromatin using sequencing analyses.
[Cancer Research] |
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| In vitro, Ambrisentan inhibited both spontaneous and induced migration/invasion capacity of different tumor cells. Whole transcriptome analysis using RNAseq indicated Ambrisentan’s inhibitory effects on the whole transcriptome of resting and PAR2-activated COLO-357 cells, which tended to normalize to an unstimulated profile.
[Scientific Reports] |
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| Investigators determined that some small molecular compounds, such as penicillic acid, papyracillic acid, and auranofin, exhibited preferential cytotoxicity to human pancreatic cancer cells under nutrient-deprived compared with nutrient-sufficient conditions.
[Journal of Biological Chemistry] |
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| The authors highlight the aberrant activation of PI3K/AKT as a key link that modulates multidrug resistance. They summarize the regulation of numerous major targets correlated with the PI3K/AKT pathway.
[Cell Death & Disease] |
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| Scientists discuss the recent advances in understanding of how α-cells regulate metabolism, with a particular focus on the postprandial state.
[Endocrinology] |
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| AXIM® Biotechnologies, Inc. announced that the United States Patent and Trademark Office has issued the company a new Notice of Allowance for a patent on anti-neoplastic compounds and methods targeting Quiescin Sulfhydryl Oxidase 1, an enzyme important for tumor cell growth, invasion and metastasis.
[ AXIM Biotechnologies, Inc.] |
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| May 16 – May 21, 2021
Lucca, Italy |
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| | The Mayo Clinic – Jacksonville, Florida, United States |
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| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| | City of Hope – Monrovia, California, United States |
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| | Washington University in St. Louis – St. Louis, Missouri, United States |
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| | Washington University in St. Louis – St. Louis, Missouri, United States |
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