 | | Vol. 11.39 – 13 October, 2020 |
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| Researchers investigated the potential role and mechanism of calreticulin in regulating intracellular free Ca2+ dependent acute and chronic endoplasmic reticulum stress-induced epithelial-mesenchymal transition in pancreatic camcer in vitro and vivo.
[Journal of Experimental & Clinical Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that somatostatin and glucagon secretion were linked in a reciprocal feedback cycle with somatostatin inhibiting glucagon secretion at low and high glucose levels, and glucagon stimulating somatostatin secretion via the glucagon and GLP-1 receptors.
[Diabetologia] |
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| Investigators generated a mouse model with pancreas-specific deletion of PKD3, the predominant PKD isoform in mouse pancreatic acinar cells, by crossing Pkd3flox/flox mice with Pdx1-Cre transgenic mice which express Cre recombinase under the control of the mouse Pdx1 promoter.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease] |
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| Plasma glucagon responses during hyperinsulinemic-hypoglycemic clamps were assessed in dogs with spontaneous diabetes and healthy non-diabetic dogs. Plasma C-peptide responses to intravenous glucagon were measured to assess endogenous insulin secretion. Plasma pancreatic polypeptide, epinephrine and norepinephrine were measured as indices of parasympathetic and sympathoadrenal autonomic responses to insulin-induced hypoglycemia.
[American Journal of Physiology-Endocrinology and Metabolism] |
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| Scientists report that leptin augmented NMDA subtype of glutamate receptors function via Src kinase-mediated phosphorylation of the GluN2A subunit.
[Journal of Biological Chemistry] |
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| Researchers incorporated fluorescence lifetime imaging microscopy into a pancreas‐on‐chip system to establish a protocol to non‐invasively assess the viability and functionality of pancreatic β‐cells in a 3D in vitro model.
[Journal of Biophotonics] |
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| Investigators expressed mutant ITIH5 with deletion of the N-terminal secretion sequence (ITIH5Δs) in highly metastatic human pancreatic ductal adenocarcinoma (PDAC) cell lines. They used a human tissue microarray to compare ITIH5 levels in uninvolved pancreas, primary and metastatic PDAC.
[British Journal of Cancer] |
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| Scientists used sublines to screen molecular targets for the treatment of pancreatic cancer. Among the genes with increased expression levels in the sublines, they focused on those encoding cell surface receptors that may be involved in the interactions between cancer cells and the tumor microenvironment.
[Molecular Oncology] |
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| The effects of systemic administration of Porphyromonas gingivalis lipopolysaccharide on gene expression were comprehensively explored in mouse pancreas that did not demonstrate any signs of inflammation.
[International Journal of Molecular Sciences] |
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| The authors analyze the role of cancer associated fibroblasts (CAFs) in therapeutic resistance of pancreatic cancer and discuss potential CAFs-targeting strategies basing on the diverse biological functions of CAFs, thus to improve the outcome of pancreatic cancer treatment.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
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| Scientists highlight the development of in vitro cell culture models that allow systematic studies of pancreatic cell mechanobiology in response to extracellular matrix proteins, biomechanical effects, soluble factor modulation of biomechanics, substrate stiffness, fluid flow and topography.
[Frontiers in Bioengineering and Biotechnology] |
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| Nanobiotix announced that the first patient has been injected in its Phase I study evaluating NBTXR3 activated by radiation therapy for patients with pancreatic cancer.
[Nanobiotix Inc.] |
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| April 9 – April 14, 2021
Washington, DC, United States |
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| | Roswell Park Cancer Center – Buffalo, NY, United States |
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| | Van Andel Institute – Grand Rapids, Michigan, United States |
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| | The Mayo Clinic – Jacksonville, Florida, United States |
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| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
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| | Washington University in St. Louis – St. Louis, Missouri, United States |
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