 | | Vol. 11.41 – 3 November, 2020 |
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| Investigators showed that pancreatic inflammation was coupled to the emergence of a transient progenitor cell population that was readily transformed in the presence of mutant KrasG12D.
[Nature Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists introduce a novel strategy for the generation of prevascularized islet organoids by the fusion of pancreatic islet cells with functional native microvessels.
[EMBO Molecular Medicine] |
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| The authors showed that APPL2 enhances glucose-stimulated insulin secretion (GSIS) by promoting F-actin remodeling via the small GTPase Rac1 in pancreatic β-cells. β-cell specific abrogation of APPL2 impaired GSIS, leading to glucose intolerance in mice.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Functional assessment of isolated islets revealed that obese SM/J mice increased glucose‐stimulated insulin secretion, decreased basal insulin secretion, and increased islet insulin content.
[Physiological Reports] |
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| Investigators describe a protocol for mouse pancreatic islet isolation, culturing, and dissociation into a single-cell suspension. This protocol yielded highly viable cells for successful library preparation and single-cell RNA sequencing.
[STAR Protocols] |
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| Researchers found that peripheral axons release serine (Ser) to support the growth of exogenous Ser-dependent pancreatic ductal adenocarcinoma cells during Ser/Gly deprivation.
[Cell] |
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| Inhibiting CXCR4 in an experimental cancer medicine study by one week continuous infusion of the small-molecule inhibitor AMD3100 induced an integrated immune response that was detected by transcriptional analysis of paired biopsies of metastases from patients with microsatellite stable colorectal and pancreatic cancer.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| High-throughput RNA-sequencing analysis from pancreatic tissues of KCM animals revealed a significant decrease in cancer stem cell markers Aldh1a1, Klf4, EpCAM, and CD133.
[Cancer Research] |
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| Researchers investigated the anti-cancer effects of docosahexaenoic acid (DHA) in human PDAC cells in vitro and in vivo. Omega-3 polyunsaturated fatty acids such as DHA and eicosapentaenoic acid significantly inhibited the proliferation of human PDAC cells.
[PLoS One] |
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| Scientists critically review seminal and recent articles on the signaling mechanisms by which each stromal element promotes epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma.
[Signal Transduction and Targeted Therapy] |
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| Zucara Therapeutics, Inc., a diabetes life sciences company developing the first once-daily therapeutic to prevent insulin-induced hypoglycemia, announced that it has expanded the development of ZT-01, a somatostatin receptor 2 antagonist, to type 2 diabetes.
[Zucara Therapeutics, Inc.] |
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| Three PhD students at the University of Oxford have been given £80,000 each to fund their research. The award was made by the Royal Commission for the Exhibition of 1851, which seeks to support individuals with ‘exceptional promise’ in their research into industry based scientific projects. Of the ten Industrial Fellowships granted this year, three went to Oxford University students studying for science-based doctorates.
[Cherwell] |
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| April 11 – April 13, 2021
San Diego, California, United States |
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| | Pfizer – Cambridge, Massachusetts, United States |
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| | San Diego Biomedical Research Institute – La Jolla, California, United States |
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| | Zhejiang University – University of Edinburgh Institute – Haining, China |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Roswell Park Cancer Center – Buffalo, New York, United States |
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