 | | Vol. 11.42 – 10 November, 2020 |
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| Scientists found that Netrin G1 (NetG1)+ cancer-associated fibroblasts (CAFs) support pancreatic ductal adenocarcinoma survival, through a NetG1 mediated effect on glutamate/glutamine metabolism. NetG1+ CAFs were intrinsically immunosuppressive and inhibited NK cell mediated killing of tumor cells.
[Cancer Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that VPS41 was required for insulin secretory granule biogenesis and regulated insulin secretion. Loss of VPS41 in pancreatic β-cells led to a reduction in insulin SG number, changes in their transmembrane protein composition, and defects in granule regulated exocytosis.
[Diabetes] |
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| Mechanistically, Hic-5 knock down significantly inhibited the TGF-β/Smad2 signaling pathway, resulting in reduced collagen production and α-smooth muscle actin expression in activated pancreatic stellate cells.
[Scientific Reports] |
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| Investigators demonstrated that TBK1 was predominantly expressed in β-cells in mammalian islets. Proteomic and transcriptome analyses revealed that genetic silencing of TBK1 increased expression of proteins and genes essential for cell proliferation in INS-1 832/13 rat β-cells.
[Scientific Reports] |
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| The authors found that insulin signaling was downregulated by inhibition of HDAC6. HDAC6 expression was specifically observed in pancreatic β cells and was decreased in the pancreatic islets of a type 2 diabetes mouse model.
[Biochemical and Biophysical Research Communications] |
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| Investigators describe a protocol for mouse pancreatic islet isolation, culturing, and dissociation into a single-cell suspension. This protocol yielded highly viable cells for successful library preparation and single-cell RNA sequencing.
[STAR Protocols] |
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| Using chromatin activation marks, investigators mapped super-enhancers (SE) networks in pancreatic cancer associated fibroblasts and epithelial tumor cells and found them to have distinct SE profiles.
[Oncogenesis] |
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| The authors explore insights into the mechanisms by which hypersialylation plays a role in promoting metastasis, and explore the current state of sialyltransferase inhibitor development.
[British Journal of Cancer] |
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| eGenesis announced the initiation of a research collaboration with Duke University School of Medicine. The collaboration will encompass evaluation of gene-edited pancreatic islet cells in non-human primate recipients as a prerequisite to advancing to human clinical trials.
[eGenesis] |
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| May 2 – May 7, 2021
Lucca, Italy |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | San Diego Biomedical Research Institute – La Jolla, California, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, China |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Roswell Park Cancer Center – Buffalo, New York, United States |
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