 | | Vol. 11.43 – 17 November, 2020 |
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| Scientists analyzed six transcriptional datasets of primary human islet cells and found that ACE2 and TMPRSS2 were not co-expressed in single β cells.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators used three human β cell models to investigate the mechanism through which YIPF5 loss of function affects β cells. Loss of YIPF5 function in stem cell–derived islet cells resulted in proinsulin retention in the endoplasmic reticulum (ER), marked ER stress, and β cell failure.
[Journal of Clinical Investigation] |
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| In vitro stepwise protocols had been designed for differentiating human pluripotent stem cells (hPSCs) into pancreatic lineages that finally gave rise to beta cells; however, these hPSC-derived beta cells were dissimilar to adult human beta cells in key aspects of gene expression and functionality.
[Methods in Molecular Biology] |
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| Diphtheria toxin A induction resulted in an acute hyperglycemia, which was accompanied by dramatic changes in gene expression in residual β cells.
[Genes & Development] |
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| Potential regulatory proteins in pancreatitis were identified by proteomic screen using pancreatic tissues of PRSS1Tg acute pancreatitis mice. Adenoviral shRNA-mediated knockdown of identified proteins, followed by functional assays was performed to validate their roles.
[Cell Death & Disease] |
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| Using multiple reagents and antibodies, the authors showed that ACE2 was expressed in human pancreatic islets, where it was preferentially expressed in subsets of insulin producing β-cells.
[Frontiers in Endocrinology] |
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| Researchers identified a Notch-dependent feedback circuit between pancreatic cancer cells and macrophages which contributed to pancreatic ductal adenocarcinoma metastasis. In this circuit, miR-124 regulated Notch signaling in cancer cells by directly targeting the Notch ligand Jagged 1.
[Cancer Research] |
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| Organoid-derived CD44(−) cancer cells were capable of organoid re-formation and could be re-programed as CD44− expressing cancer-initiating cells in the organoid culture system.
[Cancer Letters] |
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| Scientists showed that in pancreatic tumors, the developing stroma increased tumor initiation frequency in pancreatic cancer cells in vivo by enriching for CD133+ aggressive “stem-like” cells.
[Cell Death & Disease] |
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| Researchers describe new 1,3-benzodioxole derivatives that could be potential small molecule candidates for LDHA inhibition. The synthesis was carried out by trans-esterification between aryl ester and alcohol groups from piperonyl alcohol.
[Scientific Reports] |
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| Initial studies have found increased severity of COVID-19, caused by infection with SARS-CoV-2, in patients with diabetes mellitus. Furthermore, COVID-19 might also predispose infected individuals to hyperglycaemia.
[Nature Reviews Endocrinology] |
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| eGenesis announced the initiation of a research collaboration with Duke University School of Medicine. The collaboration will encompass evaluation of gene-edited pancreatic islet cells in non-human primate recipients as a prerequisite to advancing to human clinical trials.
[eGenesis] |
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| May 1 – May 2, 2021
Lucca, Italy |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | San Diego Biomedical Research Institute – La Jolla, California, United States |
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| | Stanford University – Stanford, California, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, China |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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