| Vol. 11.45 – 15 December, 2020 |
| |
|
|
| Investigators explored the circ-0050102 expression in pancreatic cancer and its impacts on tumor malignant phenotypes, and further investigated the correlations among circ-0050102, miR-1182 and NPSR1. [Carcinogenesis] |
| |
|
|
PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Mechanistic studies revealed that the polyphenol protects β-cells against endoplasmic reticulum (ER)-stress mediated dysfunctions, modulating the activation of the protein kinase RNA-like endoplasmic reticulum kinase branch of the unfolded protein response and promoting mitochondrial dynamics. [Biomedicines] |
|
|
|
| Scientists report that calcium/calmodulin-dependent protein serine kinase (CASK) functioned as an important regulator of insulin secretion. CASK depletion in mouse islets/β cells substantially reduced insulin secretion and vesicle docking/fusion. [Cell Discovery] |
|
|
|
| Researchers used immunofluorescence confocal and immunofluorescence microscopy, immunohistochemistry, RT-qPCR, Western blotting, pharmacology, electrophysiology and insulin secretory studies in normal human, rat and mouse islets. [PLoS One] |
|
|
|
| Pre-weaned porcine islets were isolated from pancreata of pre-weaned Yorkshire piglets and cultured in a specific islet maturation media added with Nec-1 on day three of tissue culture at four different doses—0, 25, 50, 100, and 200 μM. [PLoS One] |
|
|
|
| To determine the presence of CB1 and CB2 receptors in pancreatic β cells, immunofluorescence of primary cell cultures and pancreatic sections was performed. [Islets] |
|
|
|
| MIN6 cells were treated with oxidized low-density lipoprotein for 24 hours, and then intracellular lipid droplets and cell apoptosis were quantified, and secretagogin and ER stress markers were identified by western blot analysis. [Acta Biochimica et Biophysica Sinica] |
| |
|
|
| Scientists report the generation of KS-58, a KRpep-2d derivative that is identified as a bicyclic peptide and possess unnatural amino acid structures. The in vitro data and molecular dynamics simulations suggested that KS-58 entered cells and blocked intracellular Ras–effector protein interactions. [Scientific Reports] |
| |
|
|
|
| The authors present the case that dysfunction occurs in both the immune system and β-cells, which provokes further dysfunction, and present the evidence leading to the consensus that islet autoimmunity is an essential component in the pathogenesis of type 1 diabetes mellitus. [Nature Reviews Endocrinology] |
|
|
|
| CDK13 is amplified in hepatocellular carcinoma. Consequently, selective CDK12/13 inhibitors constitute powerful research tools as well as promising anti-cancer therapeutics, either alone or in combination therapy. [Future Medicinal Chemistry] |
|
|
|
|
| Tirzepatide led to superior A1C and body weight reductions from baseline in adults with type 2 diabetes after 40 weeks of treatment in topline results from Eli Lilly and Company’s SURPASS-1 monotherapy clinical trial evaluating the efficacy and safety of tirzepatide compared to placebo. [Eli Lilly and Company] |
|
|
|
| A City of Hope Phase I trial featuring an investigational vaccine that uses a person’s own immune cells, a beta cell protein and vitamin D3 to potentially treat type 1 diabetes is now recruiting patients. The trial is part of The Wanek Family Project for Type 1 Diabetes at City of Hope, which seeks to find cures for the disease. [City of Hope] |
|
|
|
| Key Griffith University research projects have received $4.5 million in funding from the National Health and Medical Research Council. Announced on December 15 by the Federal Minister for Health, The Honorable Greg Hunt MP, the seven Ideas Grants projects will contribute to vital health and medical research. [Griffith News] |
|
|
|
|
| January 13 – 14, 2021 Virtual |
|
|
|
|
|
| University of Southern Denmark – Odense M, Denmark |
|
|
|
| University of Cincinnati – Cincinnati, Ohio, United States |
|
|
|
| NIH National Cancer Institute – Bethesda, Maryland, United States |
|
|
|
| Harvard Joslin Diabetes Center – Boston, Massachusetts, United States |
|
|
|
| University of Michigan – Ann Arbor, Michigan, United States |
|
|
|
|