Pancreatic Cell News Volume 11.45 | Dec 15 2020

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    2020-12-15 | PACN 11.45


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 11.45 – 15 December, 2020
    TOP STORY

    The
    Promoting Effects of hsa_circ_0050102 in Pancreatic Cancer and the Molecular Mechanism by Targeting miR-1182/NPSR1

    Investigators explored the circ-0050102 expression in pancreatic cancer and its impacts on tumor malignant phenotypes, and further investigated the correlations among circ-0050102, miR-1182 and NPSR1.
    [Carcinogenesis]

    Abstract
    Watch a webinar on using patient-derived iPS cells to model diabetes.
    PUBLICATIONSRanked by the impact factor of the journal
    DIABETES & PANCREATITIS

    Verbascoside Protects Pancreatic β-Cells against ER-Stress

    Mechanistic studies revealed that the polyphenol protects β-cells against endoplasmic reticulum (ER)-stress mediated dysfunctions, modulating the activation of the protein kinase RNA-like endoplasmic reticulum kinase branch of the unfolded protein response and promoting mitochondrial dynamics.
    [Biomedicines]

    Full ArticleGraphical Abstract

    CASK
    Modulates the Assembly and Function of the Mint1/Munc18-1 Complex to Regulate Insulin Secretion

    Scientists report that calcium/calmodulin-dependent protein serine kinase (CASK) functioned as an important regulator of insulin secretion. CASK depletion in mouse islets/β cells substantially reduced insulin secretion and vesicle docking/fusion.
    [Cell Discovery]

    Full Article

    Heterogeneous Expression of CFTR
    in Insulin-Secreting β-Cells of the Normal Human Islet

    Researchers used immunofluorescence confocal and immunofluorescence microscopy, immunohistochemistry, RT-qPCR, Western blotting, pharmacology, electrophysiology and insulin secretory studies in normal human, rat and mouse islets.
    [PLoS One]

    Full Article

    Dose-Dependent
    Effects of Necrostatin-1 Supplementation to Tissue Culture Media of Young Porcine Islets

    Pre-weaned porcine islets were isolated from pancreata of pre-weaned Yorkshire piglets and cultured in a specific islet maturation media added with Nec-1 on day three of tissue culture at four different doses—0, 25, 50, 100, and 200 μM.
    [PLoS One]

    Full Article

    Cannabinoid
    Receptors Are Differentially Regulated in the Pancreatic Islets during the Early Development of Metabolic Syndrome

    To determine the presence of CB1 and CB2 receptors in pancreatic β cells, immunofluorescence of primary cell cultures and pancreatic sections was performed.
    [Islets]

    Full Article

    A
    Novel Secretagogin/ATF4 Pathway Is Involved in Oxidized LDL-Induced Endoplasmic Reticulum Stress and Islet β-Cell Apoptosis

    MIN6 cells were treated with oxidized low-density lipoprotein for 24 hours, and then intracellular lipid droplets and cell apoptosis were quantified, and secretagogin and ER stress markers were identified by western blot analysis.
    [Acta Biochimica et Biophysica Sinica]

    Abstract
    PANCREATIC CANCER

    Generation
    of KS-58 as the First K-Ras(G12D)-Inhibitory Peptide Presenting Anti-Cancer Activity In Vivo

    Scientists report the generation of KS-58, a KRpep-2d derivative that is identified as a bicyclic peptide and possess unnatural amino acid structures. The in vitro data and molecular dynamics simulations suggested that KS-58 entered cells and blocked intracellular Ras–effector protein interactions.
    [Scientific Reports]

    Full Article


    Register for a recorded organoid panel discussion moderated by Dr. James Wells
    REVIEWS

    Type
    1 Diabetes Mellitus as a Disease of the β-Cell (Do Not Blame the Immune System?)

    The authors present the case that dysfunction occurs in both the immune system and β-cells, which provokes further dysfunction, and present the evidence leading to the consensus that islet autoimmunity is an essential component in the pathogenesis of type 1 diabetes mellitus.
    [Nature Reviews Endocrinology]

    Full Article

    The
    Promise and Current Status of CDK12/13 Inhibition for the Treatment of Cancer

    CDK13 is amplified in hepatocellular carcinoma. Consequently, selective CDK12/13 inhibitors constitute powerful research tools as well as promising anti-cancer therapeutics, either alone or in combination therapy.
    [Future Medicinal Chemistry]

    Abstract
    INDUSTRY AND POLICY NEWS

    Lilly’s
    Tirzepatide Significantly Reduced A1C and Body Weight in People with Type 2 Diabetes

    Tirzepatide led to superior A1C and body weight reductions from baseline in adults with type 2 diabetes after 40 weeks of treatment in topline results from Eli Lilly and Company’s SURPASS-1 monotherapy clinical trial evaluating the efficacy and safety of tirzepatide compared to placebo.
    [Eli Lilly and Company]

    Press Release

    City
    of Hope Now Enrolling Patients for Phase I Type 1 Diabetes Investigational Vaccine Trial

    A City of Hope Phase I trial featuring an investigational vaccine that uses a person’s own immune cells, a beta cell protein and vitamin D3 to potentially treat type 1 diabetes is now recruiting patients. The trial is part of The Wanek Family Project for Type 1 Diabetes at City of Hope, which seeks to find cures for the disease.
    [City of Hope]

    Press Release

    NHMRC
    Awards Griffith University $4.5 Million in Research Funding

    Key Griffith University research projects have received $4.5 million in funding from the National Health and Medical Research Council. Announced on December 15 by the Federal Minister for Health, The Honorable Greg Hunt MP, the seven Ideas Grants projects will contribute to vital health and medical research.
    [Griffith News]

    Press Release
    FEATURED EVENT

    Antibodies and Vaccines as Drugs for COVID-19

    January 13 – 14, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Associate Professor – Diabetes Care

    University of Southern Denmark – Odense M, Denmark

    Associate
    Professor – Cancer Biology

    University of Cincinnati – Cincinnati, Ohio, United States

    Senior
    Investigator – Replication Stress and Chromatin Alterations

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral
    Fellow – Pancreatic Beta Cell Biology

    Harvard Joslin Diabetes Center – Boston, Massachusetts, United States

    Postdoctoral Fellowship – Diabetes Mellitus and Islet Biology

    University of Michigan – Ann Arbor, Michigan, United States

    > See All Jobs

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