 | | Vol. 12.01 – 12 January, 2021 |
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| Scientists demonstrated that ZIP4 activated ZEB1 and YAP1 through distinct mechanisms. The ZIP4-miR-373-LATS2-ZEB1/YAP1-ITGA3 signaling axis has a significant impact on pancreatic cancer metastasis and EMT plasticity.
[Gastroenterology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | | The authors performed miRNA-seq analysis from isolated Interstitial cells of Cajal in diabetic mice and plasma from patients with idiopathic and diabetic gastroparesis.
[Gastroenterology] |
| | Researchers showed that lean mice became insulin resistant after being administered exosomes isolated from the feces of obese mice fed a high-fat diet or from patients with type II diabetes.
[Nature Communications] |
| | Investigators describe a protocol for the continuous patterning of hepatic, biliary, and pancreatic structures from a 3D culture of human pluripotent stem cells.
[Nature Protocols] |
| | Cluster analysis revealed two distinct human beta cell populations, which diverged by mitochondrial and nuclear DNA-encoded oxidative phosphorylation gene expression in healthy and diabetic individuals, and in the newborn but not in adult mice.
[Scientific Reports] |
| | Scientists developed a stable β-cell line that retains the characteristics of mature β-cells.
[Scientific Reports] |
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| Scientists engineered CC chemokine receptor 2-targeting ultrasmall copper nanoparticles as nanovehicles not only for targeted positron emission tomography imaging by intrinsic radiolabeling with 64Cu but also for loading and delivery of the chemotherapy drug gemcitabine to PDAC.
[ACS Nano] |
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| RNA sequencing of murine PDAC liver metastasis-infiltrated neutrophils showed that P2RX1-deficient neutrophils express increased levels of immunosuppressive molecules, including PD-L1, and have enhanced mitochondrial metabolism.
[Nature Communications] |
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| Researchers report a new small-molecule inhibitor with potent antitumor bioactivity, which inhibited multiple oncogenic processes in pancreatic cancer.
[Oncogene] |
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| Investigators clarified the mechanisms on early activation of heat shock factor 1 (HSF1) and its role in pancreatic cancer tumorigenesis.
[Journal of Experimental & Clinical Cancer Research] |
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| Researchers found that the expression of ABCA8, a member of ABCA subfamily transporters, was significantly increased in human pancreatic cancer (PC) cells after gemcitabine (GEM) treatment, as well as in established GEM-resistant PC cells.
[Cell Death Discovery] |
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| Scientists provide a concise overview of the core physiology of glucagon like peptide-1 secretion and action, and the role of the peptide in human health, disease, and therapeutics.
[Nature Metabolism] |
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| REMD Biotherapeutics, Inc., together with its subsidiary, Beijing CoSci-REMD Bio Med-Tech Co, Ltd., announced they have completed enrollment and have top-line results in a Phase II study of REMD-477 in patients with type 1 diabetes.
[REMD Biotherapeutics, Inc. (Business Wire, Inc.)] |
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| Adocia announced it has developed a hydrogel scaffold that hosts and protects pancreatic β cells for replacement of the missing cells of people with type 1 diabetes.
[Adocia] |
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| January 25 – 28, 2021
Virtual |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| | Fondazione Human Technopole – Milan, Italy |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | University of Southern Denmark – Odense M, Denmark |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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