 | | Vol. 12.02 – 19 January, 2021 |
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| Scientists evaluated the efficacy of TR1801-ADC, a newly developed ADC composed of a MET antibody conjugated to the highly potent pyrrolobenzodiazepine toxin-linker Tesirine. They first evaluated MET expression and subcellular localization in pancreatic cancer cell lines, human tumors and patient derived xenografts.
[Clinical Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | | Researchers showed that shRNA-mediated SIX2 or SIX3 suppression in human pancreatic adult islets impaired insulin secretion.
[Genes & Development] |
| | To directly define the roles of insulin and IGF-1 receptors in the maintenance of pluripotency and differentiation of stem cells, scientists knocked out both the receptors in induced pluripotent stem cells.
[Molecular Medicine] |
| | Dermal fibroblasts (DF) are critical for effective wound healing, the authors sought to establish whether there were any differences in DF cultured from type 2 diabetes mellitus donors or those without diabetes.
[Scientific Reports] |
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| Researchers revealed that increased ataxia-telangiectasia group D-associated gene (ATDC) levels protected cancer cells from reactive oxygen species via stabilization of nuclear factor erythroid 2-related factor 2 (NRF2).
[Genes & Development] |
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| Investigators evaluated improvements to therapeutic efficacy through combination therapy incorporating NanoKnife and M1 virus. They showed that irreversible electroporation triggered reactive oxygen species-dependent apoptosis in pancreatic cancer cells mediated by phosphatidylinositol-3-kinase/protein kinase B pathway suppression.
[Cancer Letters] |
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| The authors generated human cancer cell lines of pancreatic and lung origin carrying an inducible shRNA against NRF2 and PERK. They report that PERK-related phosphorylation of NRF2 was only critical in Keap1 wildtype cells to escape its degradation, but showed no direct effect on nuclear import or transcriptional activity of NRF2.
[Cell Death & Disease] |
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| The roles and mechanisms of dopamine to affect the chemotherapeutic efficacy for pancreatic cancer were studied. Multi-omics results revealed that there was a tumor-promoting vicious cycle involving murine pancreatic cancer cells and tumor-associated macrophages.
[Cancer Immunology Immunotherapy] |
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| Investigators assessed the effectiveness of hypermethylation at the CpG island of ZNF154, a previously reported multi-cancer specific signature for use in a blood-based cancer detection assay.
[Scientific Reports] |
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| The authors highlight research that has led to a new understanding of retinal pathophysiology during diabetes mellitus and that has uncovered potential new therapeutic avenues to treat this debilitating disease.
[Nature Reviews Endocrinology] |
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| Investigators cover the accumulating data about the roles of the bromodomain and extraterminal domain (BET) family in innate immunity and discuss the attractive prospect of manipulating the BET family as a new treatment for disease.
[Signal Transduction and Targeted Therapy] |
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| NantKwest, Inc. and ImmunityBio, Inc. announced early interim results of its PD-L1 t-haNK protocols showing median survival rates more than doubled that of the historic rate in patients with advanced metastatic pancreatic cancer for which no other FDA-approved treatment exists.
[NantKwest, Inc.] |
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| Erytech Pharma S.A. announced the first patient enrolled in a Phase I investigator sponsored trial, named rESPECT, of its lead product eryaspase for the first-line treatment of pancreatic cancer.
[Erytech Pharma S.A.] |
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| February 3 – 23, 2021
Virtual |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Novo Nordisk – Copenhagen, Denmark |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| | Fondazione Human Technopole – Milan, Italy |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
