 | | Vol. 12.03 – 26 January, 2021 |
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| Scientists identified CEACAM7 as a potential therapeutic target in PDAC and described the development of CEACAM7-targeted CAR T cells with efficacy against PDAC.
[Clinical Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | | Researchers generated induced pluripotent stem cells (iPSCs) from a patient with FOXA2 haploinsufficiency followed by beta-cell differentiation to understand the role of FOXA2 during pancreatic beta-cell development.
[Cell Death & Disease] |
| | Investigators suggested that microdose lithium conferred a protective effect on islet β-cells via targeting the GSK3β-regulated Nrf2 antioxidant response and thereby ameliorated type 1 diabetes mellitus and its related kidney impairment.
[Antioxidants] |
| | The authors showed that La-related protein 1 (LARP1) was the most expressed LARP in mouse islets and human β-cells, being two–four-fold more abundant than LARP1B, a member of the family that also interacts with rapamycin complex 1.
[Scientific Reports] |
| | Scientists used total HDL and HDL subfractions isolated from human plasma, to test insulin secretion under different glucose concentrations as well as insulin content and cholesterol efflux in the insulinoma MIN-6 cell line.
[Journal of Endocrinological Investigation] |
| | The authors characterized the effects of a highly specific inhibitor of thioredoxin reductase, AM12, on the viability and function of insulin-secreting MIN6 cells and isolated NMRI mouse islets.
[Naunyn-Schmiedeberg’s Archives of Pharmacology] |
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| In light of the newly discovered cancer-associated fibroblast heterogeneity, scientists investigated how Hedgehog pathway inhibition reprogramed the PDAC microenvironment.
[Clinical Cancer Research] |
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| Researchers genetically knocked out MUC4 in PDAC cells that did not express and did express truncated O-glycans using CRISPR/Cas9 technology.
[Cancer Letters] |
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| Investigators report the endogenous expression of transient receptor potential ankyrin type 1 (TRPA1) channels in human pancreatic adenocarcinoma cell lines and provided insights into the function of the TRPA1 protein in the Panc-1 cell line.
[Scientific Reports] |
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| Scientists present the physiological roles, pharmacology, and clinical studies of lipid receptors and discuss the challenges associated with their clinical development for the treatment of type 2 diabetes mellitus.
[Nature Reviews Endocrinology] |
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| The authors discuss the roles of lncRNAs in type 2 diabetes (T2D) and cardiovascular disease (CVD) conditions and their diagnostic potential as molecular biomarkers for CVD complications in T2D.
[Diagnostics] |
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| Creative Medical Technology Holdings announced positive data and filing of a patent application covering the use of ImmCelz® in the prevention and regression of type 1 diabetes.
[Creative Medical Technology Holdings] |
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| Oramed Pharmaceuticals, Inc. announced that randomization of patients in its first Phase III study of its oral insulin capsule ORMD-0801 for the treatment of type 2 diabetes was underway.
[Oramed Pharmaceuticals, Inc.] |
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| February 1 – 3, 2021
Virtual |
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| | Nature Reviews Endocrinology – London, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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