 | | Vol. 12.04 – 2 February, 2021 |
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| The authors identified an inhibitor of insulin receptor and IGF1 receptor signaling in mouse β-cells, which they named the insulin inhibitory receptor.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | | Investigators showed that subtle differences in β-cell maturity, defined using PDX1 and MAFA expression, contributed to islet operation.
[Nature Communications] |
| | Using chromatin conformation capture, researchers showed that an enhancer cluster in the STARD10 type 2 diabetes locus forms a defined 3D chromatin domain.
[Cell Reports] |
| | Scientists hypothesized that beta cell autophagy was dysfunctional in type 1 diabetes and that there was a progressive loss during early diabetes development.
[Diabetologia] |
| | Investigators showed that pericytes produced multiple components of the mouse pancreatic and islet interstitial and basement membrane matrices.
[Scientific Reports] |
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| The authors investigated the role of interleukin-17A (IL17A) and its effect on tumor fibroblasts and the tumor microenvironment. They used a spontaneous PDAC mouse model crossed to IL17A knockout mice to show an extensive desmoplastic reaction, without impaired immune infiltration.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers demonstrated that under nutrient-replete conditions, loss of autophagy in PDAC led to a relatively restricted impairment of amino acid pools, with cysteine levels showing a significant drop.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists hypothesized that SHCBP1 and O-linked GlcNAc transferase (EOGT) could mediate PDAC progression by influencing NOTCH1 O-GlcNAcylation.
[Genomics] |
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| Human pancreatic cancer cell lines MIA PaCa-2 and PANC-1 clones were established either expressing either JNK1 or -2 shRNA in a stable manner.
[Cancer Gene Therapy] |
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| Researchers investigated the anti‐cancer function of free and nano‐encapsulated hydroxytyrosol and curcumin, and their combinations on the PANC‐1 cell line.
[Environmental Toxicology] |
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| Several activated immune pathways have been identified in the islets of people who experienced itrauterine growth restriction, with alternations in the levels of IL-1β and IL-4 as well as changes in TGFβ signaling. Leptin levels are also altered.
[Nature Reviews Endocrinology] |
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The authors highlight the advantages and limitations of recent advances in drug formulation that improve protein stability and pharmacokinetics, prolong drug delivery, or enable alternative dosage forms for the management of diabetes.
[Science Translational Medicine] |
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| Interpace Biosciences, Inc. announced that it has executed a license agreement with Rutgers, the State University of New Jersey, and Massachusetts General Hospital for a novel monoclonal antibody platform, Das-1, used in the risk assessment of pancreatic cysts.
[Interpace Biosciences, Inc.] |
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| Vertex Pharmaceuticals, Incorporated announced that the FDA has cleared the IND, enabling the company to proceed with initiating a clinical trial for VX-880, an investigational stem cell-derived, fully differentiated pancreatic islet cell therapy to treat T1D.
[Vertex Pharmaceuticals, Inc.] |
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| February 18, 2021
Virtual |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | Nature Reviews Endocrinology – London, England, United Kingdom |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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