 | | Vol. 12.05 – 9 February, 2021 |
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| Scientists showed that SARS-CoV-2 infected cells of the human exocrine and endocrine pancreas ex vivo and in vivo. They demonstrated that human β-cells expressed viral entry proteins, and SARS-CoV-2 infected and replicated in cultured human islets.
[Nature Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | | The authors compared the differentiation of pancreatic endocrine cells between Insulinoma-associated protein 1 (Insm1) null and Insm1 SNAG domain mutants to explore the specific function of the SNAG domain of Insm1.
[Diabetes] |
| | Researchers explored the effects of extracellular vesicles, released from both rodent and human isolated adipocytes and human adipose tissue explants, on survival and function of pancreatic β-cells and human pancreatic islets.
[JCI Insight] |
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| The authors performed laser capture microdissection of PDAC samples to define their cancer- and stroma-specific molecular subtypes and identified a prognostic gene expression signature for short-term and long-term survival.
[Clinical Cancer Research] |
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| Investigators proposed RAD50-interacting protein 1 (RINT1) as an essential mediator of cellular homeostasis in PDAC. RINT1 depletion caused severe growth defects in vitro associated with accumulation of DNA double-strand breaks, G2 cell cycle arrest, disruption of Golgi-ER homeostasis, and cell death.
[Cancer Research] |
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| Researchers described the discovery of a series of novel hydroxyquinoline glucose-regulated protein (GRP78) inhibitors. A representative analog, YUM70, inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues.
[Cancer Research] |
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| Scientists showed a key role of MGST1 in inhibiting ferroptosis in cell cultures and mouse xenograft models. Ferroptosis activators induced MGST1 upregulation in human PDAC cell lines in an NFE2L2-dependent manner.
[Cell Chemical Biology] |
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| Researchers evaluated Stimulator of Interferon Genes (STING) agonist activation of PDAC cell interferon (IFN)-αβ-receptor signaling in systemic antitumor immune responses.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Because obesity and diabetes affect pancreatic cancer progression and chemoresistance, scientists investigated the effect of AdipoRon on orthotopic tumor growth of Panc02 pancreatic cancer cells in diet-induced obese prediabetic mice.
[Scientific Reports] |
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| The author highlights key scientific advances potentially poised to improve the quality of life and treatment outcomes in type 1 diabetes.
[Diabetologia] |
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| Scientists provide a comprehensive summary of the key clinical trials exploring immunotherapy in PDAC, followed by a brief discussion of emerging molecular mechanisms that may explain the relative failure of immunotherapy in pancreas cancer.
[Cancer Letters] |
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| β cell replacement by islet transplantation can restore a physiologic reserve capacity for insulin secretion, confirming thresholds for functional β cell mass required for independence from insulin therapy.
[Annals of the New York Academy of Sciences] |
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| Dong-A ST Co., Ltd. announced that it successfully completed the proof-of-concept study for ‘DA-1241,’ an investigational first-in-class small molecule with a mechanism of GPR119 agonist under clinical development, in patients with type 2 diabetes.
[Dong-A ST Co., Ltd. (Business Wire, Inc.)] |
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| Erytech Pharma S.A. announced that TRYbeCA-1, a Phase III clinical trial evaluating eryaspase in second-line pancreatic cancer, will continue without modification following a planned interim superiority analysis conducted by an Independent Data Monitoring Committee.
[Erytech Pharma S.A.] |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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