| Vol. 12.06 – 16 February, 2021 |
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Scientists showed that secretion of luminal glycoprotein 2 from pancreatic acinar cells was induced in a TNF–dependent manner in mice with chemically induced colitis. [Nature Communications] |
| | PUBLICATIONSRanked by the impact factor of the journal |
| | | Using conditional loss-of-function and lineage tracing approaches, researchers showed that SOX2 was required cell autonomously in p27−/− endocrine cells for these to give rise to tumors, and in stem cells for promotion of tumorigenesis. [Proceedings of the National Academy of Sciences of the United States of America] |
| | The authors demonstrated that virgin beta cells could proliferate but did so at rates similar to those of mature beta cells from the same islet under normal and challenged conditions. [Diabetes] |
| | The authors investigated contributions of regulatory programs active during pancreatic development to type 2 diabetes risk. [eLife] |
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| | Scientists report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes was diminished. [npj Regenerative Medicine] |
| | Investigators identified CD81 as a novel surface marker that labeled immature stressed and dedifferentiated β-cells in the adult mouse and human islets [Molecular Metabolism] |
| | Researchers showed that human and mouse pancreatic α- and β-cells expressed the catecholamine biosynthetic and signaling machinery, and that α-cells synthesized dopamine de novo. [Translational Psychiatry] |
| | Mesenchymal stromal/stem cells (MSCs) were studied in direct contact and indirect contact with murine pancreatic β cell line MIN6-cells damaged by nitrosourea derivative streptozotocin in vitro. [Stem Cell Research & Therapy] |
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| Investigators performed a stable isotope labelling by amino acids in cell culture (SILAC)-based quantitative proteomics analysis of oxaliplatin-resistant and sensitive pancreatic cancer PANC-1 cells. [Cancers] |
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| Active derivatives significantly blocked c-Met phosphorylation, inhibited cell growth in 3D spheroid cultures and also induced apoptosis as revealed by Annexin V/propidium iodide flow cytometric assay in AsPc-1 cells. [Scientific Reports] |
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| Using a cancer-associated fibroblast (CAF)-derived extracellular matrix (ECM) model, scientists uncovered that iso3/iso4 were required to sustain transforming growth factor beta1-dependent CAF activation, secrete immunosuppressive cytokines, and produce a pro-tumoral ECM. [Scientific Reports] |
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| The authors summarize the biological function of key driver genes and pharmaceutical targets in PDAC. In addition, they conclude the results of molecularly targeted therapies in clinical trials and discuss how to utilize these genetic alterations in further clinical practice. [Acta Pharmacologica Sinica] |
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| AIM ImmunoTech, Inc. announced that the Dutch Health and Youth Care Inspectorate has approved treatment for six pancreatic cancer patients as part of a new, follow-up Early Access Program at Erasmus Medical Center in the Netherlands. [AIM ImmunoTech, Inc.] |
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| Xeris Pharmaceuticals, Inc. announced that the European Commission has approved Ogluo™ injection for the treatment of severe hypoglycaemia in adults, adolescents, and children aged two years and over with diabetes mellitus. [Xeris Pharmaceuticals, Inc.] |
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| April 21 – 23, 2021 Virtual |
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| University of Copenhagen – Copenhagen, Denmark |
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| University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States |
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| Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| Karolinska Institutet – Stockholm, Sweden |
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| Weill Cornell Medicine – New York, New York, United States |
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