Pancreatic Cell News Volume 12.06 | Feb 16 2021

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    2021-02-16 | PACN 12.06


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.06 – 16 February, 2021
    TOP STORY

    Pancreatic Glycoprotein 2 Is a First Line of Defense for Mucosal Protection in Intestinal Inflammation

    Scientists showed that secretion of luminal glycoprotein 2 from pancreatic acinar cells was induced in a TNF–dependent manner in mice with chemically induced colitis.
    [Nature Communications]

    Full Article

    Dr. Sylvia Boj discusses how organoids are revolutionizing drug screening for cystic fibrosis in this webinar
    PUBLICATIONSRanked by the impact factor of the journal

    SOX2 Is Required Independently in Both Stem and Differentiated Cells for Pituitary Tumorigenesis in p27-Null Mice

    Using conditional loss-of-function and lineage tracing approaches, researchers showed that SOX2 was required cell autonomously in p27−/− endocrine cells for these to give rise to tumors, and in stem cells for promotion of tumorigenesis.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Virgin Beta Cells at the Neogenic Niche Proliferate Normally and Mature Slowly

    The authors demonstrated that virgin beta cells could proliferate but did so at rates similar to those of mature beta cells from the same islet under normal and challenged conditions.
    [Diabetes]

    Abstract

    Pancreatic Progenitor Epigenome Maps Prioritize Type 2 Diabetes Risk Genes with Roles in Development

    The authors investigated contributions of regulatory programs active during pancreatic development to type 2 diabetes risk.
    [eLife]

    Full Article

    DNA Methylation Status Correlates with Adult β-Cell Regeneration Capacity

    Scientists report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes was diminished.
    [npj Regenerative Medicine]

    Full ArticlePress Release

    CD81 Marks Immature and Dedifferentiated Pancreatic β-Cells

    Investigators identified CD81 as a novel surface marker that labeled immature stressed and dedifferentiated β-cells in the adult mouse and human islets
    [Molecular Metabolism]

    AbstractFull Article

    Dopamine Regulates Pancreatic Glucagon and Insulin Secretion via Adrenergic and Dopaminergic Receptors

    Researchers showed that human and mouse pancreatic α- and β-cells expressed the catecholamine biosynthetic and signaling machinery, and that α-cells synthesized dopamine de novo.
    [Translational Psychiatry]

    Full ArticlePress Release

    Intrapancreatic MSC Transplantation Facilitates Pancreatic Islet Regeneration

    Mesenchymal stromal/stem cells (MSCs) were studied in direct contact and indirect contact with murine pancreatic β cell line MIN6-cells damaged by nitrosourea derivative streptozotocin in vitro.
    [Stem Cell Research & Therapy]

    Full Article

    SILAC-Based Quantitative Proteomic Analysis of Oxaliplatin-Resistant Pancreatic Cancer Cells

    Investigators performed a stable isotope labelling by amino acids in cell culture (SILAC)-based quantitative proteomics analysis of oxaliplatin-resistant and sensitive pancreatic cancer PANC-1 cells.
    [Cancers]

    Full ArticleGraphical Abstract

    Imidazopyridine Hydrazone Derivatives Exert Antiproliferative Effect on Lung and Pancreatic Cancer Cells and Potentially Inhibit Receptor Tyrosine Kinases Including C-Met

    Active derivatives significantly blocked c-Met phosphorylation, inhibited cell growth in 3D spheroid cultures and also induced apoptosis as revealed by Annexin V/propidium iodide flow cytometric assay in AsPc-1 cells.
    [Scientific Reports]

    Full Article

    Palladin Isoforms 3 and 4 Regulate Cancer-Associated Fibroblast Pro-Tumor Functions in Pancreatic Ductal Adenocarcinoma

    Using a cancer-associated fibroblast (CAF)-derived extracellular matrix (ECM) model, scientists uncovered that iso3/iso4 were required to sustain transforming growth factor beta1-dependent CAF activation, secrete immunosuppressive cytokines, and produce a pro-tumoral ECM.
    [Scientific Reports]

    Full Article

    Download an e-book covering the evolution of organoids, from their development to updated applications and future outlooks.
    REVIEWS

    Mutations in Key Driver Genes of Pancreatic Cancer: Molecularly Targeted Therapies and Other Clinical Implications

    The authors summarize the biological function of key driver genes and pharmaceutical targets in PDAC. In addition, they conclude the results of molecularly targeted therapies in clinical trials and discuss how to utilize these genetic alterations in further clinical practice.
    [Acta Pharmacologica Sinica]

    Abstract

    INDUSTRY AND POLICY NEWS

    AIM ImmunoTech Announces the Expansion of its Pancreatic Cancer Program to Include New Patients in the Netherlands

    AIM ImmunoTech, Inc. announced that the Dutch Health and Youth Care Inspectorate has approved treatment for six pancreatic cancer patients as part of a new, follow-up Early Access Program at Erasmus Medical Center in the Netherlands.
    [AIM ImmunoTech, Inc.]

    Press Release

    Xeris Pharmaceuticals Receives European Commission Approval of Ogluo™ (Glucagon) Injection for the Treatment of Severe Hypoglycaemia in Adults, Adolescents, and Children Aged Two Years and Over with Diabetes Mellitus

    Xeris Pharmaceuticals, Inc. announced that the European Commission has approved Ogluo™ injection for the treatment of severe hypoglycaemia in adults, adolescents, and children aged two years and over with diabetes mellitus.
    [Xeris Pharmaceuticals, Inc.]

    Press Release

    FEATURED EVENT

    European Immunogenetics and Histocompatibility Conference

    April 21 – 23, 2021
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Fellowships – Basic Metabolic Research

    University of Copenhagen – Copenhagen, Denmark

    Research Positions – Diabetes Research

    University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States

    Postdoctoral Fellowship – Human Cancers

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Postodctoral Researcher – Molecular Cardiology

    Karolinska Institutet – Stockholm, Sweden

    Scientist – Metabolism Research

    Weill Cornell Medicine – New York, New York, United States

    > See All Jobs

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