Pancreatic Cell News Volume 12.07 | Feb 23 2021

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    Justin.choi
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    2021-02-23 | PACN 12.07


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.07 – 23 February, 2021
    TOP STORY

    Immune Stimulating Antibody‐Photosensitizer Conjugates via Fc‐Mediated Dendritic Cell Phagocytosis and Phototriggered Immunogenic Cell Death for KRAS‐Mutated Pancreatic Cancer Treatment

    Cetuximab‐conjugated maleimide‐polyethylene glycol‐chlorin e6 (CMPC) was designed to strengthen its antitumor efficacy. With a strong affinity for epidermal growth factor receptor overexpressing Aspc‐1 cells, CMPC with laser exerted the greatest cytotoxicity and induction of immunogenic cell death.
    [Small]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Nuclear IL-33/SMAD Signaling Axis Promotes Cancer Development in Chronic Inflammation

    Interleukin (IL)‐33 was highly expressed in the skin and pancreatic epithelial cells in chronic inflammation, leading to a markedly repressed Smad6 expression as well as dramatically upregulated p‐SMAD2/3 and p‐SMAD1/5 in the epithelial cells.
    [EMBO Journal]

    AbstractPress ReleaseGraphical Abstract

    Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar Cells

    The authors revealed that control of the expression of KRAS and its effectors regulated the sensitivity of acinar cells to transformation by oncogenic Kras mutations.
    [Cancer Research]

    Abstract

    A Role for PAK1 Mediated Phosphorylation of β-Catenin Ser552 in the Regulation of Insulin Secretion

    Researchers found that a Ser552Ala version of β-catenin attenuated glucose stimulated insulin secretion indicating a functional role for Ser552 phosphorylation of β-catenin in insulin secretion.
    [Biochemical Journal]

    Abstract

    Analysis of the Behavior of 2D Monolayers and 3D Spheroid Human Pancreatic Beta Cells Derived from Induced Pluripotent Stem Cells in a Microfluidic Environment

    The authors compared and discussed two strategies for culturing human pancreatic β-cells derived from human induced pluripotent stem cells in microfluidic biochips.
    [Journal of Biotechnology]

    Abstract

    NAD+ Depletion by Type I Interferon Signaling Sensitizes Pancreatic Cancer Cells to NAMPT Inhibition

    Investigators showed that interferon signaling, present in a subset of PDAC tumors, substantially lowered NAD(H) levels through up-regulating the expression of NAD-consuming enzymes PARP9, PARP10, and PARP14.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Cx43 Phosphorylation Sites Regulate Pancreatic Cancer Metastasis

    Cx43, the most widely expressed connexin, regulates cell behaviors, including migration and proliferation. Scientists hypothesized that Cx43 could regulate PDAC progression.
    [Oncogene]

    Abstract

    UCHL3 Promotes Aerobic Glycolysis of Pancreatic Cancer through Upregulating LDHA Expression

    Scientists showed that ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) expression was significantly increased in the pancreatic cancer tissues and cells, and that knocking down UCHL3 noticeably inhibited cell viability and aerobic glycolysis.
    [Clinical and Translational Oncology]

    Abstract

    A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells

    Researchers investigated whether fucoxanthinol (FxOH), induced apoptosis in human pancreatic cancer cells. FxOH significantly promoted the growth of human pancreatic cancer PANC-1 cells.
    [Nutrition and Cancer]

    Abstract

    Pathogen infection studies lacked an optimal culture system. Then she used organoids.
    REVIEWS

    Drivers of Gene Expression Dysregulation in Pancreatic Cancer

    The authors assess the current understanding of mechanisms of gene expression dysregulation. They focus on four drivers of gene expression dysregulation, including mutations, transcription factors, epigenetic regulators, and RNA stability/isoform regulation, in the context of PDAC pathogenesis.
    [Trends in Cancer]

    Abstract

    Molecular Alterations in Pancreatic Cancer: Transfer to the Clinic

    New drug combinations and new concepts to improve drug delivery into the tumor, as well as the development of preclinical predictive assays, are being explored and provide optimism and prospects for better therapies.
    [International Journal of Molecular Sciences]

    AbstractFull ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    JDRF Announces New Center of Excellence in New England to Advance Type 1 Diabetes Research

    JDRF announced, in collaboration with the Harvard Stem Cell Institute, the launch of the JDRF Center of Excellence in New England.
    [JDRF (PR Newswire, LLC)]

    Press Release

    Rousselot Biomedical, a Darling Ingredients Brand, Joins European ENLIGHT Project to Develop a 3D Living Model of Pancreatic Tissue

    Darling Ingredients, Inc. announced that its Rousselot Biomedical brand is joining the European project ENLIGHT. Researchers from academic centers and leading industries across Europe are joining forces to develop a living model of the pancreas to enable better testing of diabetes medication.
    [Darling Ingredients, Inc.]

    Press Release

    FEATURED EVENT

    ISSCR 2021 Annual Meeting

    June 21 – 26, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Tenure Track Scientist Positions – Metabolism

    Rutgers Robert Wood Johnson Medical School – Rutgers, New Jersey, United States

    Research Assistant – Metabolic Check Points

    Baylor College of Medicine – Houston, Texas, United States

    Director – Solid Tumors

    Gilead Sciences, Inc. – Foster City, California, United States

    Postdoctoral Fellow – p53 and Metabolism

    The Francis Crick Institute – London, England, United Kingdom

    PhD Program – Institute of Physiology

    Institute of Physiology – Prague, Czech Republic

    > See All Jobs

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