 | | Vol. 12.08 – 2 March, 2021 |
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| Scientists confirmed the remarkable potential of Glucagon Like Peptide 1 Receptor agonist conjugation for the delivery of antisense oligonucleotides to pancreatic beta cell by effectively knocking down islet amyloid polypeptide mRNA, a potential proapoptotic target, in mice.
[Journal of the American Chemical Society] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that PDAC tumor cells present an increased sialylation that could be recognized by Siglec-7 and Siglec-9 on myeloid cells.
[Nature Communications] |
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| Taurine upregulated gene 1 (TUG1) antagonized miR-376b-3p and upregulated dihydropyrimidine dehydrogenase. TUG1 depletion induced susceptibility to 5-FU in BxPC-3 and PK-9 pancreatic cell lines.
[Cancer Research] |
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| Scientists demonstrated that the histone variant H2A.Z was highly expressed in PDAC cell lines and PDAC patients and that its overexpression correlated with poor prognosis.
[Oncogene] |
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| Inhibition of Laminin γ2 (LAMC2) in pancreatic cancer (PC) cells enhanced the gemcitabine sensitivity and induction of apoptosis. It inhibited colony formation ability, migration, and invasion potential.
[Carcinogenesis] |
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| Investigators suggested that Amatuximab inhibited the adhesion of cancer cells to peritoneum and suppressed the stemness and viability of those, that led to enhance the sensitivity for gemcitabine.
[BMC Cancer] |
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| The authors evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor to maintain glucose homeostasis in type 1 diabetic rodents.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers designed and characterized a millimeter-size particle system of poly-ethylene glycol featuring internal toroidal spiral channels, called toroidal spiral particles.
[Biomaterials Science] |
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| Scientists showed that protectin D1 (PD1) ameliorated acute pancreatitis by decreasing early infiltration of neutrophils into the pancreas and neutrophil extracellular traps formation through peptidylarginine deiminase 4.
[International Immunopharmacology] |
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| The authors review the available data on the role of leukemia inhibitory factor in pancreatic ductal adenocarcinoma promotion, and discuss the evidence supporting its potential role as a biomarker and target of effective anti-cancer therapy.
[Archivum Immunologiae et Therapiae Experimentalis] |
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| ViaCyte, Inc. and W. L. Gore & Associates, Inc. announced the two companies have signed an expanded joint development agreement covering the development and use of proprietary Gore materials and device capabilities to further optimize ViaCyte’s portfolio of product candidates for the treatment of diabetes.
[ViaCyte, Inc. (PR Newswire, Inc.)] |
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| May 17 – 21, 2021
Virtual |
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| | University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Rutgers Robert Wood Johnson Medical School – Rutgers, New Jersey, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
