 | | Vol. 12.09 – 9 March, 2021 |
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| Investigators used a dual-recombinase genetic mouse model of spontaneous PDAC to delete type I collagen specifically in myofibroblasts.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Loss of insulin-secreting pancreatic β cells through apoptosis contributes to the progression of type 2 diabetes, but underlying mechanisms remain elusive. The authors identified a pathway in which the cell death inhibitor ARC paradoxically became a killer during diabetes.
[Developmental Cell] |
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| Investigators showed that premalignant pancreatic cells seed distant stealth metastasis that eventually developed into manifest metastasis.
[Oncogene] |
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| A comprehensive metabolomic study of the response of HK-2 cells, a human cell line derived from normal proximal tubular epithelial cells, to hyperglycemic, hypoxic diabetic-like milieu has been performed.
[Scientific Reports] |
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| Researchers identified the Ferlin family plasma membrane repair factor Myoferlin as selectively and highly enriched on the membrane of pancreatic cancer lysosomes.
[Nature Cell Biology] |
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| The authors identified E26 transformation-specific homologous factor as a key molecule in decreasing the sensitivity of pancreatic cancer cells to cancer stem cells’ niche stimulus.
[Gut] |
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| Researchers report that interleukin-17 receptor B (IL-17RB) formed a homodimer and recruited mixed-lineage kinase 4, a dual kinase, to phosphorylate it at tyrosine-447 upon treatment with IL-17B in vitro. Higher amounts of phosphorylated IL-17RB in tumor specimens obtained from patients with pancreatic cancer correlated with a worse prognosis.
[Science Translational Medicine] |
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| Investigators report that carcinoma-associated fibroblasts induced β5 integrin expression in tumor cells in a TGF-β dependent manner, making them an efficient drug delivery target for the tumor-penetrating peptide iRGD.
[Nature Communications] |
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| Investigators combined an empiric antibody-based flow cytometry screen with a cyclic immunofluorescence imaging platform and a comprehensive bioinformatical and experimental evaluation for off-tumor expression to identify PDAC-specific cell surface markers.
[Nature Communications] |
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| Researchers report the selection for clonal human PDAC cells that survived and adapted to limiting levels of both glucose and glutamine. They found that adapted clones exhibit increased growth in vitro.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists synthesized a new mitochondrial uncoupler MB1-47 and tested its effect on cancer cell metabolism and the anticancer activity in pancreatic cancer cell models and murine tumor transplantation models.
[Oncogene] |
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| Investigators hypothesized that resistance to ETC inhibitors from the biguanide class could be induced by the inactivation of SMAD4, an important tumor suppressor involved in transforming growth factor β signaling and associated with the altered mitochondrial activity.
[Oncogene] |
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| The authors explore the genetic and metabolic aspects of diabetes and obesity and discuss some of the latest work and emerging ideas related to basic biological mechanisms, translational research, and clinical applications.
[Cell] |
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| Eli Lilly and Company and Biolojic Design Ltd. announced a research collaboration and license agreement that will leverage Biolojic’s AI-based multibody platform to discover and develop a potential novel antibody-based therapy for the treatment of diabetes.
[Eli Lilly and Company] |
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| April 26 – 30, 2021
Virtual |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Shanghai Jiao Tong University School of Medicine- Shanghai, China |
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| | Cancer Research Center of Lyon – Lyon, France |
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| | CyberCoders – San Diego, California, United States |
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| | Rutgers Robert Wood Johnson Medical School – Rutgers, New Jersey, United States |
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