| Vol. 12.11 – 23 March, 2021 |
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| Investigators provided evidence that macropinocytosis was operational in the pancreatic tumor stroma. They found that glutamine deficiency triggered macropinocytic uptake in pancreatic cancer-associated fibroblasts. [Cancer Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that glucose-dependent insulinotropic polypeptide (GIP) potentiated amino acid–stimulated glucagon secretion, documenting a similar nutrient-dependent action to that described in β cells. [Science Advances] |
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| Researchers determined whether recombinant Islet NeoGenesis Associated Protein (rINGAP) and its active core, a pentadecapeptide INGAP104–118, protected β cells against cytokine-induced death. [Cell Death Discovery] |
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| To investigate islet sympathetic innervation in type 1 diabetes (T1D), sympathetic tyrosine hydroxylase axons were analyzed in control non-diabetic organ donors, non-diabetic islet autoantibody-positive individuals, and age-matched persons with T1D. [Scientific Reports] |
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| Investigators evaluated the effects of short-term exposure to dimethyl sulfoxide, a polar aprotic solvent commonly used in drug screening, on physiological characteristics of MIN6-K8 cells [Histochemistry and Cell Biology] |
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| The authors used high concentration glucose-induced INS-1 cells to examine the effects of Nifuroxazide on high glucose-induced cell function by glucose-stimulated insulin secretion. [European Journal of Pharmacology] |
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| Scientists analyzed the relation between pancreatic cancer-derived PDAC upregulated factor and cancer cachexia in mice and its clinical significance. [Experimental and Molecular Medicine] |
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| Researchers explored multifunctional nanobubbles named IR780-NBs-DTX as novel ultrasound contrast agents for dual-mode targeted imaging and photothermal ablation combined with chemotherapy for pancreatic cancer. [Scientific Reports] |
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| Scientists compared PANC-1 and MIA PaCa-2 pancreatic cancer cells which were, respectively, resistant and sensitive to MEK- and PI3K-targeted therapy. [Biochemical and Biophysical Research Communications] |
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| The authors review the metabolic pathways that PDAC uses to support their growth in the setting of an austere tumor microenvironment. [Nature Reviews Gastroenterology & Hepatology] |
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| Scientists provide an overview of the strategies and pathways underlying the extreme capacity for animals to store and mobilize lipids during nutritionally stressful environmental conditions and highlight accompanying resilience phenotypes that allow these animals to develop and tolerate such profound metabolic phenotypes. [Developmental Cell] |
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| Investigators conceptualize the various insights into the mechanisms underlying pancreatic cancer cachexia according to the three dimensions to expose its particular complexity and the challenges that face clinicians in trying to devise therapeutic interventions. [British Journal of Cancer] |
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| AzurRx BioPharma, Inc. announced it has completed enrollment in its Phase II trial evaluating MS1819 in combination with the current standard of care, porcine-derived pancreatic enzyme replacement therapy (PERT), for the treatment of severe exocrine pancreatic insufficiency in patients with cystic fibrosis. [AzurRx BioPharma, Inc.] |
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| Zealand Pharma A/S announced that the FDA has approved dasiglucagon injection for the treatment of severe hypoglycemia in pediatric and adult patients with diabetes aged six years and above. [Zealand Pharma A/S (Globe Newswire, Inc.)] |
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| September 5 – 8, 2021 Exeter, England, United Kingdom |
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| Rutgers University – New Brunswick, New Jersey, United States |
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| Chr. Hansen A/S – Hørsholm, Denmark |
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| Harvard Medical School – Boston, Massachusetts, United States, |
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| University of Michigan – Ann Arbor, Michigan, United States |
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