 | | Vol. 12.12 – 30 March, 2021 |
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| The authors applied a non-genetic lineage tracing method of human pancreatic exocrine acinar and duct cells that allowed cell-type-specific gene expression profiling by RNA sequencing.
[Cell Death & Differentiation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The effects of fetuin-A were assessed during in vitro maturation of porcine neonatal islet cell clusters and in adult human islets. Expression alterations were examined via microarray, RNA sequencing and reverse transcription quantitative real-time PCR, proteins were analyzed by western blotting and immunostaining, and insulin secretion was quantified in static incubations.
[Diabetologia] |
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| Investigators showed that gestational vitamin B6 deficiency decreased serotonin levels in maternal pancreatic islets and reduced β-cell proliferation in an serotonin receptor 2B-dependent manner.
[Communications Biology] |
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| Researchers suggested that accumulation of endogenous mitochondrial double-stranded RNA following degradosome knockdown depended on the proliferative capacity of the cells and was not a mediator of the type I interferon response in human pancreatic beta cells.
[Autoimmunity Highlights] |
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| Scientists showed that hydrophobic components of bitter melon fruit extract increased ATP production and augmented insulin secretion from β-cells, consequently decreasing blood glucose levels.
[British Journal of Nutrition] |
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| The authors investigated the potential role and mechanisms of activating transcription factor 4 (ATF4) in cancer-associated fibroblasts-induced malignancy and gemcitabine resistance. They demonstrated that ATF4 was overexpressed in PDAC and associated with a poor prognosis.
[Cell Death & Disease] |
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| Most pancreatic ductal adenocarcinoma (PDAC) cells showed similar pleomorphic morphologies in 2D culture. Under 3D culture, PDAC cells with high E-cadherin and low vimentin expression levels formed small round spheres encircled with flat lining cells, whereas those with high vimentin and low E-cadherin expression levels formed large grape-like spheres without lining cells and were highly proliferative.
[Scientific Reports] |
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| It was initially confirmed that escin, at concentrations >10 µM, significantly inhibited the proliferation of several pancreatic cancer cell lines.
[Oncology Reports] |
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| This review highlights knowledge gaps and opportunities to improve the understanding of T1D pathogenesis and outlines emerging therapies to treat or prevent T1D and reduce the burden of T1D.
[Journal of Clinical Investigation] |
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| Fractyl Laboratories Inc. announced the enrollment of the first patient in a pivotal clinical trial of Revita® DMR for patients with type 2 diabetes. The trial, called REVITA-T2Di, will evaluate the ability of a single Revita DMR treatment to allow patients currently on insulin therapy but with inadequate glycemic control to achieve durable insulin-free glycemic control.
[Fractyl Laboratories Inc.] |
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| | Shanghai Jiao Tong University School of Medicine- Shanghai, China |
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| | Harvard Medical School – Boston, Massachusetts, United States, |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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