 | | Vol. 12.13 – 6 April, 2021 |
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| Researchers observed state-specific enrichment of fasting glucose and type 2 diabetes genome-wide association studies for beta cells and enrichment for other endocrine cell types.
[Nature Genetics] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that proliferative endothelial cells modulated macrophage (MΦ) infiltration and phenotype during β cell loss, and recruited MΦs were essential for β cell recovery.
[npj Regenerative Medicine] |
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| Researchers used a cell-tagging dye, CFDA-SE, to permanently label pancreatic duct cells through an intraductal infusion technique.
[Experimental and Molecular Medicine] |
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| Scientists demonstrated that B-cell CLL/lymphoma 3 (Bcl3) impacted pancreatic carcinogenesis by restraining cancer stem cell expansion and by curtailing an aggressive and metastatic tumor burden in PDAC across species.
[Gastroenterology] |
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| Investigators demonstrated that Lipocalin 2 (LCN2) was robustly upregulated in murine models of pancreatic cancer, its expression was associated with reduced food consumption, and Lcn2 deletion was protective from cachexia-anorexia.
[Nature Communications] |
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| Researchers report a novel role of regulator of calcineurin 1, isoform 4 (RCAN1.4) in regulating PDAC progression. They demonstrated that RCAN1.4 expression was decreased significantly in PDAC tissues compared with that in para-cancerous tissues, and correlated with poor prognosis of patients with pancreatic cancer.
[Oncogene] |
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| Scientists confirmed that mind bomb 1 (MIB1) expression was elevated in pancreatic cancer tissues and that high levels of MIB associated with unfavorable prognosis. Overexpression of MIB1 enhanced proliferation and invasion of pancreatic cancer cells both in vitro and in vivo.
[Molecular Oncology] |
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| The role of miR-30d in the proliferation and metastasis of pancreatic cancer cells was determined using in vitro and in vivo assays.
[Cell Death & Disease] |
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| The authors used single cell RNA sequencing to reveal that AXL was expressed highly in tumor cells that had a mesenchymal-like phenotype and that AXL expression correlated with classic markers of epithelial to mesenchymal transition.
[Molecular Cancer Research] |
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| Scientists identified preoperative plasma protein biomarkers with the potential to predict early recurrence after resection of PDAC.
[Scientific Reports] |
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| FGD5-AS1 accelerated cell proliferation and migration via sponging miR-520a-3p and upregulating KIAA1522.
[Cancer Biology & Therapy] |
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| The authors discuss the development of the most widely available insulin preparations and provide evidence-based insight into their use in clinical practice.
[Cell Metabolism] |
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| Investigators discuss current challenges surrounding the generation, delivery, and engraftment of stem cell-derived islet-like cells, along with strategies to induce durable tolerance to grafted cells, with an eye toward a functional cellular-based therapy enabling insulin independence for patients with diabetes.
[Cell Metabolism] |
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| Bluestar Genomics announced it has received FDA Breakthrough Device designation for its proprietary noninvasive pancreatic cancer detection test in patients with new-onset diabetes.
[Bluestar Genomics (Business Wire, Inc.)] |
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| Celon Pharma S.A. announced the successful completion of a Phase I trial of its second generation GPR40 agonist, CPL’280. This agent is in development for the treatment of Diabetes and Diabetic Neuropathy and met its primary endpoint, with no adverse safety signals detected.
[Celon Pharma S.A. (Globe Newswire, Inc)] |
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| October 27 – 29, 2021
Tokyo, Japan |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Shanghai Jiao Tong University School of Medicine- Shanghai, China |
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