DIABETES RB Regulates Pancreas Development by Stabilizing Pdx1 Results demonstrate an unanticipated regulatory mechanism for pancreatic development and β-cell function, which involves RB-mediated stabilization of the pancreas-specific transcription factor Pdx-1. [EMBO J] Recombinant Human Prolactin Promotes Human Beta Cell Survival via Inhibition of Extrinsic and Intrinsic Apoptosis Pathways The proportion of apoptotic beta cells was significantly lowered in the presence of recombinant human prolactin under both cell death-induced conditions. [Diabetologia] Islet-1 Regulates Arx Transcription During Pancreatic Islet α-Cell Development Researchers showed that the number of Arx+ cells was significantly reduced in the pancreata of embryos deficient for the Islet-1 transcription factor, which was also supported by the reduction in Aristaless related homeodomain protein (Arx) mRNA levels. [J Biol Chem] Stimulus-Induced S-Nitrosylation of Syntaxin 4 Impacts Insulin Granule Exocytosis Data indicate a significant role for reactive nitrogen species in the insulin exocytosis mechanism in β-cells and expose a potential pathophysiological exploitation of this mechanism to underlie dysfunctional exocytosis. [J Biol Chem] Dynamic Regulation of PDX-1 and FoxO1 Expression by FoxA2 in Dexamethasone-Induced Pancreatic β-cells Dysfunction The results of the present study demonstrated that forkhead box (Fox)A2 could dynamically regulate FoxO1 and pancreatic and duodenal homeobox-1 (PDX-1) expression in pancreatic β-cells treated with dexamethasone (DEX), which provides new important information on the transcriptional regulation of FoxO1 and PDX-1 in DEX-induced pancreatic β-cells. [Endocrinology] An Indirect Role for NK Cells in a CD4+ T-Cell-Dependent Mouse Model of Type I Diabetes The requirement for natural killer (NK) cells in β-cell destruction in the CD4-dependent T-cell antigen receptor transgenic NOD4.1 mice was examined. [Immunol Cell Biol] PANCREATIC CANCER TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation Researchers show that TBK1 directly activates AKT by phosphorylation of the canonical activation loop and hydrophobic motif sites independently of PDK1 and mTORC2. [Mol Cell] Pancreatic Cancers Require Autophagy for Tumor Growth Results suggest that, unlike in other cancers where autophagy inhibition may synergize with chemotherapy or targeted agents by preventing the up-regulation of autophagy as a reactive survival mechanism, autophagy is actually required for tumorigenic growth of pancreatic cancers de novo, and drugs that inactivate this process may have a unique clinical utility in treating pancreatic cancers and other malignancies with a similar dependence on autophagy. [Genes Dev] Association of Alcohol Intake with Pancreatic Cancer Mortality in Never Smokers Results strengthen the evidence that alcohol consumption, specifically liquor consumption of 3 or more drinks per day, increases pancreatic cancer mortality independent of smoking. [Arch Intern Med] Ep-CAM Is a Significant Prognostic Factor in Pancreatic Cancer Patients by Suppressing Cell Activity Epithelial cell adhesion molecule (Ep-CAM) expression was found to be related to the suppression of pancreatic cancer cell activity and the good prognosis in pancreatic cancer patients receiving the curative resection. [Oncogene] Synergistic Effect Between Erlotinib and MEK Inhibitors in KRAS Wildtype Human Pancreatic Cancer Cells Results suggest that combination therapy of an EGFR and MAP kinase kinase (MEK) inhibitors may have enhanced efficacy in patients with pancreatic cancer. [Clin Cancer Res] MK-1775, A Potent Wee1 Inhibitor, Synergizes with Gemcitabine to Achieve Tumor Regressions, Selectively in p53-Deficient Pancreatic Cancer Xenografts Results indicate that MK-1775 selectively synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts. [Clin Cancer Res] Suppression of the uPAR-uPA System Retards Angiogenesis, Invasion and In Vivo Tumor Development in Pancreatic Cancer Cells The results of the present study demonstrate that the targeting of the uPAR-uPA system has therapeutic potential. [Mol Cancer Res] |